CAS 484-42-4

Angiotensina I

Descrizione:

Angiotensina I è un ormone peptidico che svolge un ruolo cruciale nella regolazione della pressione sanguigna e dell'equilibrio dei fluidi nel corpo. È un decapeptide, composto da dieci aminoacidi, ed è derivato dall'angiotensinogeno, una proteina precursore prodotta dal fegato. Angiotensina I è biologicamente inattivo ma viene convertito nella forma attiva, Angiotensina II, dall'azione dell'enzima convertitore dell'angiotensina (ACE). Questa conversione è un passaggio chiave nel sistema renina-angiotensina, che regola la pressione sanguigna e l'equilibrio elettrolitico. Angiotensina I è caratterizzato dalla sua specifica sequenza di aminoacidi, che include residui di prolina e istidina, contribuendo alle sue proprietà strutturali. È solubile in acqua e ha una vita media relativamente breve in circolazione, rendendolo un componente transitorio del sistema renina-angiotensina. Lo studio di Angiotensina I e dei suoi derivati è significativo in farmacologia, in particolare nello sviluppo di farmaci antipertensivi che mirano al sistema renina-angiotensina per gestire condizioni come l'ipertensione e l'insufficienza cardiaca.

Formula: C₆₂H₈₉N₁₇O₁₄

InChI: InChI=1/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(C)C)C(=O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CC(=O)O)N)O)O)O)O

Sinonimi:

• H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
• L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine

Angiotensin I (human)

CAS: 484-42-4

Angiotensin I (human) stimulates the release of aldosterone, another hormone, from the adrenal cortex. It acts as a precursor to angiotensin II. It acts as endogenous peptide substrate for angiotensin converting enzyme (ACE), precursor to the vasoconstrictor peptide angiotensin II This Thermo Scient

Formula: C₆₂H₈₉N₁₇O₁₄

Colore e forma: White to off-white, Powder or crystals or crystalline powder

Peso molecolare: 1296.50

Ref: 02-J62102

Angiotensin I

CAS: 484-42-4

Angiotensin I, DRVYIHPFHL, is cleaved by angiotensin-converting enzyme (ACE) yielding Ang II and the dipeptide His-Leu. Ang I is also converted to Ang II by chymase, especially in the human heart. Hence, this mast cell protease is also involved in blood pressure regulation. The chymase pathway gains importance in inflammatory conditions.

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: 97.9%

Colore e forma: White

Peso molecolare: 1296.5

Ref: 01-4002346

Angiotensin 1, Human

CAS: 484-42-4

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1296.4756

Ref: IN-DA00DEOP

Angiotensin I (human, mouse, rat)

CAS: 484-42-4

Angiotensin I (human, mouse, rat)

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: ≥98%

Peso molecolare: 1296.48

Ref: 54-BUP21214

Angiotensin I (human, mouse, rat)

CAS: 484-42-4

Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: >99.99%

Colore e forma: Solid

Peso molecolare: 1296.48

Ref: TM-TP1295

Angiotensin I

CAS: 484-42-4

The renin angiotensin system (RAS), consists of many angiotensin peptides involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and RAS is widely studied in relation to lifestyle-related diseases.Angiotensin I (Ang-I), is the first angiotensin to be produced upon activation of the RAS system. It is produced by the cleavage of angiotensinogen (AGT), catalysed by the aspartylprotease, renin. The dicarboxyl-peptidase angiotensin converting enzyme (ACE), then removes two amino acids from the C-terminus of Ang-I to form angiotensin II (Ang-II), and His-Leu.Ang-I is also converted to Ang-II by chymase, especially in the human heart. The chymase pathway is important in inflammatory conditions.

Formula: C₆₂H₈₉N₁₇O₁₄

Peso molecolare: 1,296.48 g/mol

Ref: 3D-CRB1000132

Angiotensin I, human

CAS: 484-42-4

Angiotensin I is a protein encoded by the AGTR1 gene. It is a precursor to angiotensin II, which causes vasoconstriction and has other effects on blood vessels, kidneys, and the heart. Angiotensin I is produced by proteolytic cleavage of pro-angiotensinogen in the liver. The mouse monoclonal antibody to human angiotensin I (mAb-HAI) recognizes both human and bovine angiotensin I. This antibody can be used for immunohistochemistry or Western blot analysis of cells from mice that have been injected with mAb-HAI. It has also been shown to reduce kidney fibrosis in mice when it is administered as a subcutaneous injection three times per week.

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: Min. 95%

Peso molecolare: 1,296.48 g/mol

Ref: 3D-FA73185

Angiotensin I (Human)

CAS: 484-42-4

Angiotensin I (Human) is a peptide that functions as a hormone. It is the major regulator of blood pressure and plays an important role in the regulation of fluid balance, electrolyte balance, and heart rate. Angiotensin I (Human) is a receptor ligand that binds to cell surface receptors which are coupled to G proteins. It has been used extensively as a research tool for studying protein interactions and ion channels.

Formula: C₆₂H₈₉N₁₇O₁₄

Purezza: Min. 95%

Peso molecolare: 1,296.5 g/mol

Ref: 3D-PAN-4007-V

Angiotensin I (Human)

CAS: 484-42-4

Angiotensin I (Human) is a protein that is found in the blood and other tissues. It is a peptide hormone, which acts on the kidneys to increase blood pressure and on the heart to increase cardiac output. This protein has been detected in several biological samples such as plasma, serum, or urine. Angiotensin I (Human) can be used as an enzyme form of angiotensin 1-converting enzyme (ACE). ACE catalyzes the conversion of angiotensin I to its active form, angiotensin II. Angiotensin II has been shown to reduce the production of inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. It also stimulates vascular smooth muscle cells and increases the production of nitric oxide by these cells, leading to vasodilation. The measurement of this enzyme form in a sample may help determine disease activity in patients with bowel disease or squamous cell cancer of the skin.

Formula: C₆₂H₈₉N₁₇O₁₄•2CH₃COOH•4H₂O

Purezza: Min. 95%

Peso molecolare: 1,488.66 g/mol

Ref: 3D-PAN-4007