CAS 50-44-2

6-Mercaptopurina

Descrizione:

6-Mercaptopurina è un analogo della purina e un antimetabolita utilizzato principalmente nel trattamento di alcuni tipi di leucemia, in particolare la leucemia linfoblastica acuta (LLA) e la leucemia mieloide cronica (LMC). La sua formula chimica è C5H4N4S e presenta un gruppo tiol (-SH) che contribuisce alla sua reattività e attività biologica. Il composto agisce inibendo la sintesi dei nucleotidi, interferendo così con la sintesi del DNA e dell'RNA, che è cruciale per le cellule cancerose in rapida divisione. 6-Mercaptopurina è tipicamente somministrato per via orale ed è noto per i suoi potenziali effetti collaterali, tra cui mielosoppressione, epatotossicità e disturbi gastrointestinali. Viene metabolizzato nel fegato e la sua efficacia può essere influenzata da variazioni genetiche negli enzimi metabolici, in particolare la tiopurina S-metiltransferasi (TPMT). A causa del suo meccanismo d'azione e del profilo degli effetti collaterali, un attento monitoraggio e aggiustamenti della dose sono spesso necessari durante il trattamento. In generale, 6-Mercaptopurina rimane un importante agente terapeutico in oncologia, in particolare nelle neoplasie ematologiche pediatriche e adulte.

Formula: C₅H₄N₄S

InChI: InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key: InChIKey=GLVAUDGFNGKCSF-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC=N1)N=CN2

Sinonimi:

• 1,7-Dihydro-6H-purine-6-thione
• 1,9-Dihydro-6H-purine-6-thione
• 1,9-Dihydro-purine-6-thione
• 1H-Purine, 6-mercapto-
• 3,5-dihydro-6H-purine-6-thione
• 3,7-Dihydropurine-6-thione
• 3H-Purine-6-thiol
• 6,9-dihydro-1H-purine
• 6-Mercaptopurin
• 6-Mercaptopurine
• 6-Mp
• 6-Thiohypoxanthine
• 6-Thiopurine
• 6-Thioxopurine
• 6H-Purine-6-thione, 1,7-dihydro-
• 6H-Purine-6-thione, 1,9-dihydro-
• 6H-purine-6-thione
• 6MP
• 7-Mercapto-1,3,4,6-tetrazaindene
• 9H-Purine-6(1H)-thione
• Hypoxanthine, thio-
• Ismipur
• Leukerin
• Leupurin
• Mercaleukim
• Mercaleukin
• Mercaptopurin
• Mercaptopurina
• Mercapurin
• Mern
• Nsc 55477
• Nsc 68293
• Nsc 755
• Purimethol
• Purine-6(1H)-thione
• Purine-6-Thiol
• Purine-6-thione
• Purinethiol
• Purinethol
• Purixan
• Thiohypoxanthine

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.

Formula: C₅H₄N₄S

Purezza: 99.53% - 99.63%

Colore e forma: Yellow Crystalline Powder Solid

Peso molecolare: 152.18

Ref: TM-T0010

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine

Formula: C₅H₄N₄S

Purezza: 99.5%

Peso molecolare: 152.18

Ref: 54-BUP11953

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine

Formula: C₅H₄N₄S

Purezza: 98%

Colore e forma: Pale yellow Solid

Peso molecolare: 152.17705

Ref: 54-BI9878

6-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)

CAS: 207729-57-5, 50-44-2, 6112-76-1

Formula: C₄₁₃CH₄N₂₁₅N₂S

Peso molecolare: 155.15

Ref: 4Z-M-834

6-Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Peso molecolare: 152.18

Ref: 7W-GP0789

6-Mercaptopurine (Azathioprine EP Impurity B)

CAS: 50-44-2

Formula: C₅H₄N₄S

Colore e forma: Yellow Solid

Peso molecolare: 152.18

Ref: 4Z-M-832

6-Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 152.1771

Ref: IN-DA0038PH

6-Mercaptopurine (Standard)

CAS: 50-44-2

6-Mercaptopurine (Standard) is a reference standard for research and analysis in studies involving 6-Mercaptopurine. 6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Formula: C₅H₄N₄S

Peso molecolare: 152.18

Ref: TM-TMSM-3693

6-Mercaptopurine

CAS: 50-44-2

3,7-dihydro-6H-purine-6-thione

Formula: C₅H₄N₄S

Purezza: 98%

Peso molecolare: 152.18

Ref: IN-DG33839

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.

Formula: C₅H₄N₄S

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 152.18 g/mol

Ref: 3D-FM61589

6-Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Colore e forma: Solid

Peso molecolare: 152.18

Ref: BE-RMCM109002

6-Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Colore e forma: Solid

Peso molecolare: 152.18

Ref: BE-MU-8296

6-Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 152.18

Ref: 10-F050540

Mercaptopurine

CAS: 50-44-2

Formula: C₅H₄N₄S

Peso molecolare: 152.17

Ref: ST-EA-CP-M81000