CAS 50673-97-7

Colestolone

Descrizione:

Colestolone, con il numero CAS 50673-97-7, è un composto steroideo sintetico che è strutturalmente correlato al colesterolo. È caratterizzato dal suo schema steroideo, che consiste in quattro anelli di carbonio fusi. Colestolone è principalmente riconosciuto per il suo ruolo nella ricerca relativa al metabolismo del colesterolo e le sue potenziali applicazioni in farmacologia. Il composto presenta proprietà lipofile, consentendogli di interagire con le membrane lipidiche e influenzare vari processi biologici. Viene spesso studiato per i suoi effetti sui profili lipidici e le sue potenziali implicazioni terapeutiche in condizioni legate alla disfunzione del colesterolo. Inoltre, Colestolone può fungere da precursore o intermedio nella sintesi di altri derivati steroidei. Le sue caratteristiche di solubilità, stabilità in condizioni fisiologiche e interazioni specifiche con i recettori biologici sono aree chiave di interesse nella ricerca in corso. Come molti composti steroidei, i profili di sicurezza e tossicità sono considerazioni essenziali nella sua applicazione e studio.

Formula: C₂₇H₄₄O₂

InChI: InChI=1/C27H44O2/c1-17(2)7-6-8-18(3)23-16-24(29)25-21-10-9-19-15-20(28)11-13-26(19,4)22(21)12-14-27(23,25)5/h17-20,22-23,28H,6-16H2,1-5H3/t18-,19+,20+,22+,23-,26+,27-/m1/s1

InChI key: InChIKey=LINVVMHRTUSXHL-GGVPDPBRSA-N

SMILES: C[C@@]12C(=C3[C@@]([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])(CC1)[H])C(=O)C[C@@]2([C@@H](CCCC(C)C)C)[H]

Sinonimi:

• (3Beta,5Alpha)-3-Hydroxycholest-8(14)-En-15-One
• (3S,5S,10S,13R,17R)-17-(1,5-dimethylhexyl)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,9,11,12,16,17-dodecahydrocyclopenta[a]phenanthren-15-one
• (3β,5α)-3-Hydroxycholest-8(14)-en-15-one
• 3-Hydroxycholest-8(14)-En-15-One
• 3beta-Hydroxy-5alpha-cholest-8(14)-en-15-one
• 3β-Hydroxy-5α-cholest-8(14)-en-15-one
• 5α-Cholest-8(14)-en-3β-ol-15-one
• Cholest-8(14)-en-15-one, 3-hydroxy-, (3beta,5alpha)-
• Cholest-8(14)-en-15-one, 3-hydroxy-, (3β,5α)-
• Cholest-8(14)-en-3-ol-15-one
• Cl 274,471
• Colestolona
• Colestolona [INN-Spanish]
• Colestolone [USAN:INN]
• Colestolonum
• Colestolonum [INN-Latin]
• Unii-5P8396T5Xf
• Colestolone
• 15-ketocholestene
• 3-HYDROXY-5Α-CHOLEST-8(14)-EN-15-ONE;15-KETOCHOLESTENE
• 15-Ketosterol
• 17-(1,5-Dimethylhexyl)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,9,10,11,12,13,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-15-one
• 3-Hydroxy-5Α-Cholest-8(14)-En-15-One
• 17-(1,5-DIMETHYLHEXYL)-3-HYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,9,10,11,12,13,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-15-ONE
• 17-(1,5-Dimethylhexyl)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,9,10,11,12,13,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan
• 3-hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,10,11,12,13,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-15(9H)-one

Colestolone

CAS: 50673-97-7

Formula: C₂₇H₄₄O₂

Peso molecolare: 400.6371

Ref: IN-DA00D9NC

15-Ketocholestene

Prodotto controllato

CAS: 50673-97-7

15-Ketocholestene is a natural product that inhibits the synthesis of cholesterol by binding to cholesterol esterase, preventing the breakdown of fatty acids. It has been shown to have an inhibitory effect on liver cells, which may be due to its ability to inhibit sodium-dependent glucose uptake. 15-Ketocholestene has also been shown to reduce blood and liver cholesterol levels in Sprague-Dawley rats. The mechanism of action is not fully understood, but it has been speculated that this inhibition may be due to an alkylthio group or a carbonyl group. 15-Ketocholestene has also been shown to have anti-hepatitis effects.

Formula: C₂₇H₄₄O₂

Purezza: Min. 95%

Peso molecolare: 400.6 g/mol

Ref: 3D-ACA67397

Colestolone

CAS: 50673-97-7

Colestolone is a 15-ketosterol compound and an HMG-CoA reductase inhibitor. It can inhibit cholesterol ester transfer protein (CETP) activity in vitro with an IC₅₀ of 660 μM. As a cholesterol-lowering agent, colestolone is used in the research of endocrine and metabolic disorders, such as hyperlipidemia.

Formula: C₂₇H₄₄O₂

Peso molecolare: 400.6371

Ref: TM-T213936