CAS 56602-33-6

reagente BOP

Descrizione:

reagente BOP, o benzotriazolo-1-ossido-tris(dimetilamino)fosfonio esafluorofosfato, è un composto chimico comunemente usato nella sintesi organica, in particolare nelle reazioni di accoppiamento dei peptidi. Funziona come un agente di accoppiamento che facilita la formazione di legami ammidici tra acidi carbossilici e ammine. reagente BOP è caratterizzato dalla sua capacità di attivare gli acidi carbossilici, rendendoli più reattivi all'attacco nucleofilo da parte delle ammine. Questo reagente è tipicamente preferito per le sue condizioni di reazione dolci e la compatibilità con vari gruppi funzionali, il che minimizza le reazioni secondarie. È un solido bianco a bianco sporco che è solubile in solventi organici polari. Devono essere osservate le precauzioni di sicurezza quando si maneggia reagente BOP, poiché può essere pericoloso e causare irritazione. È essenziale un corretto stoccaggio in un luogo fresco e asciutto, lontano dall'umidità e da sostanze incompatibili, per mantenere la sua stabilità e efficacia nelle applicazioni sintetiche.

Formula: C₁₂H₂₂N₆OP·F₆P

InChI: InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1

InChI key: InChIKey=MGEVGECQZUIPSV-UHFFFAOYSA-N

SMILES: [P+](ON1C=2C(N=N1)=CC=CC2)(N(C)C)(N(C)C)N(C)C.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]

Sinonimi:

• (1H-benzotriazol-1-yloxy)[tris(dimethylamino)]phosphonium hexafluorophosphate
• (Benzotriazol-1-yloxy)tris(dimethylamino) hexafluorophosphate
• (Boranyloxy)Phosphane
• 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
• 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
• 2-(1H-Benzotriazol-1-yl)tris(dimethylamino)phosphonium hexafluorophosphate
• BOP
• BOP hexafluorophosphate
• BOP reagent
• Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
• Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate
• Castro reagent
• Castro's reagent
• Le BOP
• Methanamine, N-methyl-, phosphorus complex
• Phosphate(1-), hexafluoro-, (T-4)-(1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)phosphorus(1+)
• Phosphorus(1+), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-)

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide]

CAS: 56602-33-6

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 442.29

Ref: 3B-B1651

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98%

CAS: 56602-33-6

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecarobox

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: 98%

Colore e forma: Crystalline powder, White

Peso molecolare: 442.29

Ref: 02-A16140

(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 442.2806

Ref: IN-DA0032D4

[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate

Formula: C₁₂H₂₂N₆OP·PF₆

Purezza: ≥95%

Colore e forma: Solid-Powder

Peso molecolare: 442.28062

Ref: 54-PC2519

Benzotriazol-1-yl-oxy-tris(dimethylamino) phosphonium hexafluorophosphate (BOP Reagent)

CAS: 56602-33-6

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: ≥ 98.0%

Colore e forma: White to beige or light-yellow powder to crystals

Peso molecolare: 442.29

Ref: 7W-GE5235

Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: 98.0%

Colore e forma: Solid

Peso molecolare: 442.287

Ref: 10-F009018

BOP

CAS: 56602-33-6

BOP, also known with the name of Castro’s reagent, is a phosphonium coupling reagent used for peptide synthesis. BOP can be employed in presence of a base such as triethylamine or Hünig’s base and forms HOBt in situ, which then generates an activated ester. BOP is a very effective coupling reagent, achieving high yields, low epimerisation and high conversion rates. However, it forms the extremely toxic and carcinogenic HMPA in situ, therefore the equally efficient pyrrolidino derivative PyBOP was introduced, which leads to a less toxic by-product.

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: Min. 98 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 442.28 g/mol

Ref: 3D-FB01762

BOP Reagent

CAS: 56602-33-6

BOP Reagent is a reagent that reacts with the phosphate group of dinucleotide phosphates, such as those found in DNA and RNA. It can be used for structural analysis and to determine the presence of nucleic acids in human serum or other biological samples. The BOP Reagent binds to the phosphate group by means of intramolecular hydrogen bonding. This reaction generates a transient, covalently-bound enzyme-substrate complex that can be detected by fluorescence probe.

Formula: C₁₂H₂₂N₆OF₆P₂

Purezza: Min. 95%

Peso molecolare: 442.29 g/mol

Ref: 3D-KBP-1060-PI

Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate

Prodotto controllato

CAS: 56602-33-6

Applications A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972), Castro, B., et al.: Tetrahedron Lett., 1219 (1975)

Formula: C₁₂H₂₂N₆OP·F₆P

Colore e forma: Neat

Peso molecolare: 442.28

Ref: TR-B207000

BOP Reagent extrapure AR, 98%

CAS: 56602-33-6

Formula: C₁₂H₂₂F₆N₆OP₂

Purezza: min. 98.0%

Colore e forma: White to pale yellow, Crystalline powder, Crystalline powder

Peso molecolare: 442.29

Ref: SR-59946