CAS 59-05-2: Metotrexato

Descrizione: Metotrexato è un potente antimetabolita e agente immunosoppressore utilizzato principalmente nel trattamento di alcuni tumori, malattie autoimmuni e gravidanze ectopiche. La sua formula chimica è C20H22N8O5S e presenta una struttura ad anello di pteridina, che è cruciale per il suo meccanismo d'azione. Metotrexato agisce inibendo l'enzima diidrofolato reduttasi, interrompendo così la sintesi dei nucleotidi e influenzando infine la replicazione del DNA e la divisione cellulare. Questo lo rende particolarmente efficace contro le cellule a rapida divisione, come quelle presenti nei tumori. Metotrexato viene somministrato in varie forme, tra cui compresse orali e soluzioni iniettabili, e la sua farmacocinetica può variare in base alla via di somministrazione. Il farmaco è noto per i suoi potenziali effetti collaterali, che possono includere disturbi gastrointestinali, tossicità epatica e soppressione del midollo osseo. A causa delle sue proprietà immunosoppressive, è essenziale un attento monitoraggio durante il trattamento per gestire gli effetti avversi e le interazioni con altri farmaci. L'uso di Metotrexato a dosi più basse per condizioni autoimmuni evidenzia la sua versatilità nelle applicazioni cliniche.

Formula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChI key: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: O=C(O)CCC(NC(=O)C1=CC=C(C=C1)N(C)CC=2N=C3C(=NC2)N=C(N=C3N)N)C(=O)O

Sinonimi:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem
• Zexate

Methotrexate Hydrate

CAS: 133073-73-1 59-05-2

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purezza: >98.0%(T)(HPLC)
• Colore e forma: Light yellow to Brown powder to crystal
• Peso molecolare: 454.45 (as Anhydrous)

Methotrexate

CAS: 59-05-2

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used …

• Formula: C₂₀H₂₂N₈O₅
• Peso molecolare: 454.45

Methotrexate for peak identification CRS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Peso molecolare: 454.4393

Methotrexate RS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Peso molecolare: 454.4393

Methotrexate CRS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Crystalline Powder. Yellow. Orange. Powder.
• Peso molecolare: 454.4393

Methotrexate

CAS: 59-05-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Yellow Brown Orange Powder
• Peso molecolare: 454.17132

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Purezza: 98%
• Colore e forma: Solid
• Peso molecolare: 454.4393

Methotrexate

CAS: 59-05-2

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.

• Formula: C₂₀H₂₂N₈O₅
• Purezza: 96.84% - 99.46%
• Colore e forma: Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna Synthesis
• Peso molecolare: 454.44

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Purezza: By hplc: 99.40% (Typical Value in Batch COA)
• Colore e forma: dark yellow solid
• Peso molecolare: 454.44g/mol

Methotrexate

CAS: 59-05-2

• Purezza: 99.46%
• Peso molecolare: 454.44g/mol

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Yellow Solid
• Peso molecolare: 454.45

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Neat
• Peso molecolare: 454.44

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Neat
• Peso molecolare: 454.44

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

• Formula: C₅₀H₆₄N₁₄O₂₃·C₂HF₃O₂
• Peso molecolare: 1229.14

Methotrexate RS

CAS: 59-05-2

• Colore e forma: From Yellow To Brownish Orange Solid Powder

Methotrexate

CAS: 59-05-2

Stability Hygroscopic Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic. Not a …

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Yellow To Dark Yellow
• Peso molecolare: 454.44

Methotrexate-d3 Heptaglutamate Trifluoroacetate

CAS: 432545-63-6 59-05-2

• Formula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂
• Colore e forma: Neat
• Peso molecolare: 1232.142

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

• Formula: C₅₀H₆₄N₁₄O₂₃xC₂HF₃O₂
• Colore e forma: Neat
• Peso molecolare: 1229.12

Methotrexate (1.0mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Single Solution
• Peso molecolare: 454.44

Methotrexate

CAS: 59-05-2

Please enquire for more information about Methotrexate including the price, delivery time and more detailed …

• Formula: C₂₀H₂₂N₈O₅
• Colore e forma: Yellow Powder
• Peso molecolare: 454.44 g/mol