CAS 59865-13-3

Ciclosporina A

Descrizione:

Ciclosporina A è un polipeptide ciclico composto da 11 aminoacidi, noto principalmente per le sue proprietà immunosoppressive. È prodotto dal fungo Tolypocladium inflatum ed è ampiamente utilizzato in contesti clinici, in particolare nei trapianti d'organo e nelle malattie autoimmuni, per prevenire il rigetto d'organo e gestire condizioni come l'artrite reumatoide. La sostanza agisce inibendo l'attivazione dei linfociti T, riducendo così la risposta immunitaria. Ciclosporina A è lipofilo, il che influisce sulla sua assorbimento e distribuzione nel corpo; viene generalmente somministrato per via orale o endovenosa. La sua farmacocinetica può essere influenzata da vari fattori, inclusi l'assunzione di cibo e farmaci concomitanti, richiedendo un attento monitoraggio dei livelli ematici per evitare tossicità. Gli effetti avversi possono includere nefrotossicità, ipertensione e maggiore suscettibilità alle infezioni. A causa delle sue interazioni complesse e degli effetti collaterali, Ciclosporina A richiede una gestione attenta e aggiustamenti della dose basati sulla risposta individuale del paziente e sul contesto clinico.

Formula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Sinonimi:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1202.61

Ref: TR-C988900

Cyclosporin A-d4 (Major)

Prodotto controllato

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₀₇D₄N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Prodotto controllato

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Binds cyclophilin D and inhibits calcineurin; immunosuppressant

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: Min. 98.5 Area-%

Colore e forma: White Powder

Peso molecolare: 1,202.61 g/mol

Ref: 3D-FC20749

Cyclosporin A - Bio-X ™

CAS: 59865-13-3

Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 1,202.61 g/mol

Ref: 3D-BC164336

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Prodotto controllato

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Formula: MixtureVisitourWebsite

Colore e forma: Mixture

Peso molecolare: Mixture - Visit our Website

Ref: TR-E608165