CAS 6104-71-8

N-desmetilclozapina

Descrizione:

N-desmetilclozapina, con il numero CAS 6104-71-8, è un composto chimico che funge da metabolita della clozapina, un farmaco antipsicotico atipico utilizzato principalmente per trattare la schizofrenia. Questo composto è caratterizzato dalla sua modifica strutturale, in cui un gruppo metile viene rimosso dalla molecola di clozapina, risultando in proprietà farmacologiche alterate. N-desmetilclozapina mostra affinità per vari recettori dei neurotrasmettitori, inclusi i recettori della dopamina e della serotonina, il che può contribuire ai suoi effetti terapeutici e agli effetti collaterali. È generalmente meno potente della clozapina stessa, ma può comunque influenzare il sistema nervoso centrale. Il composto è tipicamente studiato nel contesto della farmacocinetica e della farmacodinamica, in particolare riguardo al suo ruolo nell'efficacia e nel profilo di sicurezza del trattamento con clozapina. Inoltre, comprendere le sue caratteristiche è cruciale per monitorare le interazioni farmacologiche e le risposte individuali dei pazienti in contesti clinici. Come molti metaboliti, l'attività biologica e il profilo di sicurezza di N-desmetilclozapina sono importanti per ottimizzare le strategie terapeutiche nella cura psichiatrica.

Formula: C₁₇H₁₇ClN₄

InChI: InChI=1/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2

InChI key: InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N

SMILES: ClC=1C=C2N=C(C=3C(NC2=CC1)=CC=CC3)N4CCNCC4

Sinonimi:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
• 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
• 8-chloro-11-(piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
• Acp 104
• Demethylclozapine
• Desmethylclozapine
• N-Demethylclozapine
• Norclozapine
• N-Desmethylclozapine
• N-Desmethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dib
• 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine
• Norclozapine (ACP-104)
• Clozapine EP IMpurity C
• N-Desmethyl Clozapine-d8 hydrochloride
• NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE
• N-Desmethylclozapine solution
• Clozapine EP Impurity C
• Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• 8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
• Clozapine EP Impurity C Q: What is the storage condition of
• Clozapine Impurity 3(Clozapine EP Impurity C)
• Desmethylclozapine (Norclozapine)
• CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC
• Clozapine EP Impurity C Q: What are the applications of
• Norclozapine Solution, 100ppm
• Clozapine EP Impurity C (N-Desmethyl Clozapine)
• Clozapine EP Impurity C Q: What is the CAS Number of
• 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
• Normethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• Clozapine EP Impurity CQ: What is

Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol

CAS: 6104-71-8

Colore e forma: Single Solution

Ref: 61-AMP0480.03-01

Desmethylclozapine (Norclozapine)

CAS: 6104-71-8

Colore e forma: Neat

Ref: 61-FOR0480.03

Clozapine EP Impurity C

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Colore e forma: Yellow Solid

Peso molecolare: 312.80

Ref: 4Z-C-1416

N-Desmethylclozapine

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purezza: ≥ 97.0%

Colore e forma: Yellow powder

Peso molecolare: 312.80

Ref: 7W-GP9518

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine

Purezza: ≥95%

Peso molecolare: 312.8g/mol

Ref: 54-BUP10018

N-Desmethylclozapine

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purezza: >95.0%(GC)

Colore e forma: White to Yellow powder to crystal

Peso molecolare: 312.80

Ref: 3B-D5844

8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Prodotto controllato

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Colore e forma: Neat

Peso molecolare: 312.80

Ref: 86-MM0480.03

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.

Formula: C₁₇H₁₇ClN₄

Purezza: 97.25% - 99.83%

Colore e forma: Yellow Crystalline Solid

Peso molecolare: 312.8

Ref: TM-T5158

Clozapine EP Impurity C HCl Salt

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄·HCl

Colore e forma: Yellow Solid

Peso molecolare: 312.80 36.46

Ref: 4Z-C-144

Clozapine EP Impurity C

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Peso molecolare: 312.80

Ref: ST-EA-CP-C63003

N-Desmethyl Clozapine

Prodotto controllato

CAS: 6104-71-8

Applications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.
References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

Formula: C₁₇H₁₇ClN₄

Colore e forma: Light Yellow

Peso molecolare: 312.80

Ref: TR-D292000

N-Desmethylclozapine

CAS: 6104-71-8

M01651 - N-Desmethylclozapine

Formula: C₁₇H₁₇ClN₄

Purezza: >99%

Colore e forma: Solid

Peso molecolare: 312.8

Ref: 10-M01651

N-Desmethyl clozapine

CAS: 6104-71-8

N-Desmethyl clozapine is a metabolite of the anti-psychotic drug clozapine. It has been shown to have similar effects to clozapine and can be used as an alternative treatment for chronic schizophrenia. The metabolite has been detected in human serum using a chromatographic method, which is an analytical technique that separates molecules based on their size and charge. N-Desmethyl clozapine was found to have a longer half-life than the parent compound, with a detection limit of 1 ng/mL in human serum. This metabolite also has been shown to inhibit fatty acid synthase activity and COX-1 activity in vitro, which may be responsible for its antipsychotic effects.

Formula: C₁₇H₁₇ClN₄

Purezza: Min. 95%

Peso molecolare: 312.8 g/mol

Ref: 3D-FD21255

N-DESMETHYLCLOZAPINE

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 312.7967

Ref: IN-DA00EB3S