CAS 6112-76-1

6-Mercaptopurina monoidrato

Descrizione:

6-Mercaptopurina monoidrato è un analogo della purina e un antimetabolita utilizzato principalmente nel trattamento di alcuni tipi di leucemia e malattie autoimmuni. È caratterizzato dalla sua formula chimica C5H6N4S·H2O, che indica la presenza di un gruppo mercaptano (-SH) che contribuisce alla sua reattività e attività biologica. La sostanza appare come una polvere cristallina bianca a bianco sporco ed è solubile in acqua, il che facilita la sua somministrazione in contesti clinici. Il suo meccanismo d'azione implica l'inibizione della sintesi dei nucleotidi purinici, interferendo così con la sintesi di DNA e RNA, che è cruciale per le cellule in rapida divisione. La 6-mercaptopurina viene spesso somministrata insieme ad altri farmaci per aumentare l'efficacia terapeutica e ridurre il rischio di resistenza. A causa del suo potenziale tossico, è essenziale un attento monitoraggio dei conteggi ematici e della funzione epatica durante il trattamento. Inoltre, è importante considerare fattori genetici, come le variazioni nell'enzima TPMT, che possono influenzare le risposte individuali al farmaco.

Formula: C₅H₄N₄S·H₂O

InChI: InChI=1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI key: InChIKey=WFFQYWAAEWLHJC-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC=N1)N=CN2.O

Sinonimi:

• 1,4,5,7-Tetrahydro-6H-Purine-6-Thione Hydrate
• 1,7-Dihydro-6H-Purin-6-Thion,Monohydrat
• 1,7-Dihydro-6H-Purine-6-Thionemonohydrate
• 1,7-Dihydro-6H-Purine-6-Thionmonohydrate
• 3,7-Dihydro-6H-Purine-6-Thione Hydrate
• 6-Mercapto Purine
• 6-Mercaptopurine Hydrate
• 6-Merkaptopurin,Monohydrat
• 6-Purinethiol Monohydrate
• 6-Thiohypoxanthine Monohydrate
• 6H-Purin-6-Thion,Monohydrat
• 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1)
• 6H-Purine-6-thione, 1,7-dihydro-, monohydrate
• 7H-Purine-6-Thiolate
• 9H-Purine-6-thiol hydrate
• Leukerin Monohydrate
• Mercaleukin Monohydrate
• Mercaptopurine Monohydrate, 6-Mercaptopurine
• Mercaptopurine, Monohydrate
• Purin-6-Thiol,Monohydrat
• Purine-6-Thiol, Monohydrate
• Xaluprine
• 6-Mercaptopurine monohydrate

6-Mercaptopurine Monohydrate

CAS: 50-44-2, 6112-76-1

Formula: C₅H₄N₄S·H₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light yellow to Yellow powder to crystal

Peso molecolare: 170.20

Ref: 3B-M0063

6-Mercaptopurine monohydrate, 98%

CAS: 6112-76-1

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis. This Thermo Scientific Chemicals brand product was originally part of th

Formula: C₅H₆N₄OS

Purezza: 98%

Colore e forma: Yellow, Powder

Peso molecolare: 170.19

Ref: 02-A12197

Mercaptopurine

CAS: 6112-76-1

Mercaptopurine

Formula: C₅H₄N₄SH₂O

Purezza: 100.3%

Colore e forma: Yellow

Peso molecolare: 170.02623

Ref: 47-773

MERCAPTOPURINE MONOHYDRATE CRS

CAS: 6112-76-1

MERCAPTOPURINE MONOHYDRATE CRS

Ref: 41-Y0002452

Mercaptopurine impurity standard

CAS: 154-42-7, 6112-76-1, 68-94-0, 73-24-5

Mercaptopurine impurity standard

Colore e forma: Yellow

Ref: 47-762

Mercaptopurine

CAS: 6112-76-1

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₅H₄N₄S·H₂O

Colore e forma: Yellow Crystalline Powder

Peso molecolare: 170.19

Ref: 45-1392002

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₆N₄OS

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 170.1923

Ref: IN-DA003N94

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate

Purezza: ≥95%

Peso molecolare: 170.19g/mol

Ref: 54-BUP15972

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₄N₄SH₂O

Peso molecolare: 170.19

Ref: 7W-GE6799

6-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)

CAS: 207729-57-5, 50-44-2, 6112-76-1

Formula: C₄₁₃CH₄N₂₁₅N₂S

Peso molecolare: 155.15

Ref: 4Z-M-834

Mercaptopurine Monohydrate

CAS: 6112-76-1

Colore e forma: Neat

Ref: 86-MM1537.00

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C5H4N4S.H2O

Colore e forma: Light yellow powder

Peso molecolare: 170.1923

Ref: 3T-12652909

6-Mercaptopurine monohydrate

CAS: 6112-76-1

6-Mercaptopurine monohydrate

Formula: C₅H₄N₄S·H₂O

Purezza: By hplc: 98.7% (Typical Value in Batch COA)

Colore e forma: yellow powder

Peso molecolare: 170.19g/mol

Ref: 54-BIM0129

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.

Formula: C₅H₆N₄OS

Purezza: 97.54% - 99.14%

Colore e forma: Light Yellow Crystalline Powder

Peso molecolare: 170.19

Ref: TM-T2201

6-Mercaptopurine Monohydrate (Azathioprine EP Impurity B Monohydrate)

CAS: 6112-76-1

Formula: C₅H₄N₄S·H₂O

Peso molecolare: 152.18 18.02

Ref: 4Z-M-833

6-Mercaptopurine Monohydrate

Prodotto controllato

CAS: 6112-76-1

Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),

Formula: C₅H₄N₄S·H₂O

Colore e forma: Yellow

Peso molecolare: 170.19

Ref: TR-M225450

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine is a purine analog that suppresses the production of white blood cells by inhibiting the enzyme thiopurine methyltransferase. It has been used to treat bowel disease and also for long-term suppression of the immune system in patients with autoimmune diseases. 6-Mercaptopurine is metabolized to 6-mercaptopurine, which is then converted to dinucleotide phosphate (dNTP) by group P2 enzymes. This conversion allows 6-mercaptopurine to inhibit dNTP synthesis and cell division. The effects of 6-mercaptopurine are potentiated when given in conjunction with azathioprine, another drug that inhibits purine metabolism. 6-Mercaptopurine is not active against human serum albumin or erythrocytes because it cannot be cleaved into an active form by these proteins. However, it does inhibit enzyme activities such as DNA polymerase, RNA polymerase, and protein

Formula: C₅H₄N₄S•H₂O

Purezza: Min. 97 Area-%

Colore e forma: Yellow Powder

Peso molecolare: 152.18 g/mol

Ref: 3D-FM08197

6-Mercaptopurine Monohydrate extrapure, 99%

CAS: 6112-76-1

Formula: C₅H₄N₄S·H₂O

Purezza: min. 99%

Colore e forma: Yellow, Crystalline powder

Peso molecolare: 170.19

Ref: SR-18382

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₆N₄OS

Purezza: 98.0%

Colore e forma: Solid

Peso molecolare: 170.19

Ref: 10-F358394

Mercaptopurine impurity standard

CAS: 6112-76-1

Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.

Purezza: Min. 95%

Ref: 3D-IM63780