CAS 61622-34-2

Cefotiam

Descrizione:

Cefotiam è un antibiotico cefalosporinico ad ampio spettro, classificato tra gli antibiotici beta-lattamici. È utilizzato principalmente per il trattamento di varie infezioni batteriche, in particolare quelle causate da batteri Gram-positivi e Gram-negativi. Cefotiam presenta un meccanismo d'azione che implica l'inibizione della sintesi della parete cellulare batterica, portando alla lisi cellulare e alla morte. Il composto è caratterizzato dalla sua stabilità contro alcune beta-lattamasi, il che ne migliora l'efficacia contro ceppi batterici resistenti. Viene tipicamente somministrato per iniezione ed è noto per il suo profilo di tossicità relativamente basso. Farmacocineticamente, Cefotiam è ben assorbito e ha una distribuzione favorevole nei tessuti corporei, rendendolo efficace per il trattamento di infezioni in vari siti. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, reazioni allergiche e, in rari casi, anomalie ematologiche. Come con tutti gli antibiotici, è fondamentale utilizzare Cefotiam in modo giudizioso per prevenire lo sviluppo di resistenza agli antibiotici. In generale, Cefotiam è un agente terapeutico prezioso nell'arsenale contro le infezioni batteriche.

Formula: C₁₈H₂₃N₉O₄S₃

InChI: InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1

InChI key: InChIKey=QYQDKDWGWDOFFU-IUODEOHRSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4N(CCN(C)C)N=NN4)[H]

Sinonimi:

• (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2-Amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}thio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R-trans)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)-
• 7b-[2-(Aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic Acid
• 95789-30-3
• Cgp 14221E
• Sce 963

(6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 61622-34-2

(6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula: C₁₈H₂₃N₉O₄S₃

Purezza: BR

Peso molecolare: 525.63

Ref: 54-OR1119795

Cefotiam

CAS: 61622-34-2

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

Formula: C₁₈H₂₃N₉O₄S₃

Colore e forma: Solid

Peso molecolare: 525.63

Ref: TM-T75297

Cefotiam Dihydrochloride-13C, 15N2

Prodotto controllato

CAS: 61622-34-2, 66309-69-1

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Formula: C₁₇CH₂₃N₇N₂O₄S₃•2x(HCl)

Colore e forma: Neat

Peso molecolare: 601.5295

Ref: TR-C243007

Cefotiam

CAS: 61622-34-2

Cefotiam is a broad-spectrum cephalosporin antibiotic, which is a beta-lactam compound derived from the mold Acremonium. It functions by inhibiting bacterial cell wall synthesis, particularly by targeting penicillin-binding proteins, which leads to cell lysis and death in susceptible bacteria. This mechanism of action makes it effective against various Gram-positive and Gram-negative bacteria.

Formula: C₁₈H₂₃N₉O₄S₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 525.62 g/mol

Ref: 3D-AC183647

(6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 61622-34-2

Formula: C₁₈H₂₃N₉O₄S₃

Colore e forma: Solid

Peso molecolare: 525.6281

Ref: IN-DA00IAWG