CAS 61825-94-3

Oxaliplatino

Descrizione:

Oxaliplatino è un farmaco chemioterapico a base di platino utilizzato principalmente nel trattamento del cancro colorettale. È classificato come un composto di platino di terza generazione ed è noto per la sua capacità di formare legami incrociati del DNA, che inibiscono la replicazione e la trascrizione del DNA, portando infine alla morte delle cellule tumorali. Chimicamente, Oxaliplatino è un complesso di platino di diaminocicloesano, che ne migliora l'efficacia e riduce la probabilità di resistenza rispetto ai precedenti farmaci a base di platino come il cisplatino e il carboplatino. Viene tipicamente somministrato per via endovenosa ed è spesso usato in combinazione con altri agenti chemioterapici. Oxaliplatino è caratterizzato dalla sua solubilità moderata in acqua e dalla sua stabilità in condizioni fisiologiche, sebbene possa subire idrolisi in presenza di acqua, portando alla formazione di specie reattive. Gli effetti collaterali comuni includono neuropatia periferica, nausea e mielosoppressione. Il suo meccanismo d'azione unico e il profilo degli effetti collaterali lo rendono un'opzione preziosa nell'arsenale terapeutico oncologico, in particolare per i pazienti con cancro colorettale avanzato o metastatico.

Formula: C₈H₁₄N₂O₄Pt

InChI: InChI=1/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/rC8H14N2O4Pt/c11-7-8(12)14-15(13-7)9-5-3-1-2-4-6(5)10-15/h5-6H,1-4,9-10H2/t5-,6-/m1/s1

InChI key: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES: O=C1[O-][Pt+2]2([NH2][C@]3([C@]([NH2]2)(CCCC3)[H])[H])[O-]C1=O

Sinonimi:

• Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• platinum(2+) ethanedioate (1R,2R)-cyclohexane-1,2-diamine (1:1)
• NSC-266046
• [SP-4-2-(IR-trans)]-(1,2-cyclohexanediamine-n,n')[ethanedioato(2-)-O,O']-platinum
• (1R,2R)-cyclohexane-1,2-diamine: oxalic acid: platinum(+2) cation
• xalatoplatinum
• (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]platinum
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• latin
• cyclohexane-1,2-diamine: oxalic acid: platinum
• RP-54780
• (sp-4-2)-((1r,2r)-1,2-cyclohexanediamine-n,n')(ethanedioato(2-)-O,O']platinum
• Platinum, (1,2-cyclohexanediamine-N,N′)[ethanedioato(2-)-O,O′]-, [SP-4-2-(1R-trans)]-
• platinum(4+) cyclohexane-1,2-diyldiazanide ethanedioate (1:1:1)
• Elocatin
• Oxalipatin
• trans-L-Diaminocyclohexane oxalatoplatinum
• 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-
• ι-OHP
• [SP-4-2-(1R-trans)]-(1，2-Cyclohexanediamine-N，N，)[ethanedioato(2-)-O，O’Jplatinum
• OXALIPLATIN
• OXALIPIATIN
• Lipoxal
• SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N)[ETHANEDIOATO(2-)-O,OPT
• Oxaliplatin(Eloxatin)
• NSC-266046：Elocatin
• Eloxatin
• Cis-[(1R,2R)-1,2-cyclothexanediammine-N,N`][oxalato(2-)-O,O`]platinum
• Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
• P-54780
• oxalatoplatinum
• [SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM
• oxaliplatino
• Oxaliplatin (125 mg)
• platinuM(2+) ion (1R,2R)-cyclohexane-1,2-diaMine oxalate
• oxalatoplatin
• Oxaliplatin EP/BP
• (1R-trans)-1,2-Cyclohexanediamine, platinum complex
• [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N
• 1-ohp
• (1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr
• OxaliplatinEp5
• Dacplat
• Elplat
• OXALIPLATIN (oxaliplatin)
• oxalato(1r,2r-cyclohexanediammine)platinum(ii)
• [SP-4-2-（1R-trans）]-(1,2-Cyclohexanediamine-N,Nˊ)[ethanedioato(2-)-O,Oˊ]platinum
• (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
• Oxaliplatin99%
• Oxaliplatin API

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 397.29

Ref: 3B-O0372

OXALIPLATIN CRS

CAS: 61825-94-3

OXALIPLATIN CRS

Formula: C₈H₁₂N₂O₄Pt

Peso molecolare: 395.2759

Ref: 41-Y0000271

Oxaliplatin

CAS: 61825-94-3

Inorganic or organic compounds of precious metals, whether or not chemically defined, or amalgams of precious metals, nesoi

Formula: C₈H₁₄N₂O₄Pt

Colore e forma: White Off-White Powder

Peso molecolare: 397.06015

Ref: 45-1481204

Trans-L-Diaminocyclohexane Oxalatoplatinum

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 397.2858

Ref: IN-DA0035Q1

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.

Formula: C₈H₁₄N₂O₄Pt

Purezza: 97% - 99.93%

Colore e forma: White Solid

Peso molecolare: 397.29

Ref: TM-T0164

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Purezza: 98.0 - 102.0 % (dried basis)

Colore e forma: White to almost white crystalline powder

Peso molecolare: 397.29

Ref: 7W-GP0792

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Formula: C₈H₁₄N₂O₄Pt

Purezza: ≥95%

Peso molecolare: 397.29

Ref: 54-BUP16056

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Formula: C₈H₁₄N₂O₄Pt

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 397.28575

Ref: 54-BISN0119

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Colore e forma: White To Off-White Solid

Peso molecolare: 397.29

Ref: 4Z-O-242

Oxaliplatin, EP grade

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Peso molecolare: 397.29

Ref: 7W-GP9874

Oxaliplatin

Prodotto controllato

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Colore e forma: Neat

Peso molecolare: 397.29

Ref: 86-MM0921.00

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Peso molecolare: 397.29

Ref: ST-EA-CP-O12000

Oxaliplatin

Prodotto controllato

CAS: 61825-94-3

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Formula: C₈H₁₄N₂O₄Pt

Colore e forma: Neat

Peso molecolare: 397.29

Ref: TR-O845075

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.

Formula: C₈H₁₄N₂O₄Pt

Purezza: Min. 98 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 397.29 g/mol

Ref: 3D-FD26607

Oxaliplatin - Bio-X ™

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.
Oxaliplatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₈H₁₄N₂O₄Pt

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 397.29 g/mol

Ref: 3D-BO164182

Oxaliplatin

CAS: 61825-94-3

Purezza: 98%

Peso molecolare: 397.06

Ref: 10-F556520

Oxaliplatin RS

CAS: 61825-94-3

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1032100021