CAS 6199-67-3

(+)-Cucurbitacina B

Formula: C₃₂H₄₆O₈

InChI: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI key: InChIKey=IXQKXEUSCPEQRD-DKRGWESNSA-N

SMILES: C[C@]12[C@@](C)([C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C[C@H](O)C(=O)C4(C)C)[H])[H]

Sinonimi:

• (23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,17xi,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2β,9β,10α,16α,23E)-25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
• 19-Nor-9β,10α-lanosta-5,23-diene-3,11,22-trione, 2β,16α,20,25-tetrahydroxy-9-methyl-, 25-acetate
• 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
• Amarine
• Cucurbitacine B
• Hy-N 0416
• NSC 144154
• NSC 49451

Cucurbitacin B

CAS: 6199-67-3

Formula: C₃₂H₄₆O₈

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 558.71

Ref: 3B-C3442

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₂H₄₆O₈

Purezza: (HPLC) ≥95%

Colore e forma: Powder

Peso molecolare: 558.72

Ref: 11-2310S

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B

Formula: C₃₂H₄₆O₈

Purezza: ≥95%

Peso molecolare: 558.712

Ref: 54-BUP02619

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (cucB) is a triterpenoid constituent of Cucurbitaceae vegetables and a promising phytochemical for cancer prevention, cucB induces G(2) arrest and apoptosis through a STAT3-independent but ROS-dependent mechanism in SW480 cells.

Formula: C₃₂H₄₆O₈

Purezza: 95%~99%

Colore e forma: White powder

Peso molecolare: 558.712

Ref: BP-BP0414

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.

Formula: C₃₂H₄₆O₈

Purezza: 97.1% - 99.93%

Colore e forma: Solid

Peso molecolare: 558.70

Ref: TM-T3404

Cucurbitacin B

CAS: 6199-67-3

Formula: C₃₂H₄₆O₈

Peso molecolare: 558.71

Ref: 4Z-C-266004

Cucurbitacin B

CAS: 6199-67-3

Formula: C₃₂H₄₆O₈

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 558.71

Ref: 7W-GY2441

Cucurbitacin B

CAS: 6199-67-3

Carboxylic acid with additional oxygen functions

Formula: C₃₂H₄₆O₈

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 558.71

Ref: 5G-82226

Cucurbitacin B

Prodotto controllato

CAS: 6199-67-3

Cucurbitacin B is a triterpenoid compound, which is derived from plants primarily within the Cucurbitaceae family. This compound exhibits its mode of action through the inhibition of the JAK-STAT signaling pathway, effectively disrupting processes that are critical for cell survival and proliferation. As a result, Cucurbitacin B is being extensively studied for its antiproliferative and pro-apoptotic properties, especially in the context of cancer research.

Formula: C₃₂H₄₆O₈

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 558.7 g/mol

Ref: 3D-FC66008

Cucurbitacin B

Prodotto controllato

CAS: 6199-67-3

Applications Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells.In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sun, Y., et al.: Eur. J. Pharmacol. 768, 28 (2015); Ren, G., et al.: J. Nat. Med. 69, 522 (2015); C&E News p. 10, Dec. 5, 2016j

Formula: C₃₂H₄₆O₈

Colore e forma: Neat

Peso molecolare: 558.7

Ref: TR-C833550