CAS 62996-74-1

Staurosporina

Descrizione:

Staurosporina è un potente alcaloide derivato dal batterio Streptomyces staurosporeus, noto per i suoi effetti inibitori ad ampio spettro sulle chinasi. È caratterizzato dalla sua complessa struttura tetraciclica, che contribuisce alla sua attività biologica. Staurosporina mostra un'alta affinità per varie chinasi, comprese quelle coinvolte nelle vie di segnalazione cellulare, rendendolo uno strumento prezioso nella ricerca per studiare processi cellulari come l'apoptosi e la proliferazione cellulare. Il composto è tipicamente utilizzato in ambienti di laboratorio per indagare i meccanismi del cancro e di altre malattie. Staurosporina è anche riconosciuto per le sue potenziali applicazioni terapeutiche, sebbene il suo uso sia limitato a causa della sua natura non selettiva e della tossicità associata. In termini di proprietà fisiche, è un solido cristallino solubile in solventi organici ma con solubilità limitata in acqua. Come sostanza chimica da ricerca, è importante maneggiare Staurosporina con cura, seguendo i protocolli di sicurezza a causa dei suoi potenti effetti biologici.

Formula: C₂₈H₂₆N₄O₃

InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/p+1/t17-,20-,26-,28+/m1/s1

InChI key: InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8

Sinonimi:

• (5R,6S,7S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5R,6S,7S,9S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-N,5-dimethyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-aminium
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
• 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• Alkaloid AM-2282 from Streptomyces
• Am-2282
• Antibiotic 230
• Antibiotic AM 2282
• Ccris 3272
• Cgp 39360
• Staurosporin
• (+)-Staurosporine
• Staurosporine
• STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
• [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• Staurosporine,AM-2282,STS
• STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+%
• Stauroporine
• [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE
• 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE
• STAUROSPORINE, STREPTOMYCES STAUROSPOREUS
• STAUROSPORINE, STREPTOMYCES SPECIES
• Staurosporine, Antibiotic AM-2282
• (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt
• STAUROSPORINE, 99+%.
• ANTIBIOTIC M 193
• 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• STSP
• Staurosporineinsolution
• InSolution Staurosporine, Streptomyces sp
• Staurosporine,98%
• [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• STAUROSPORINE READY-MADE SOLUTION
• STAUROSPORINE FROM STREPTOMYCES SP.
• Staurosporine(CGP 41251)
• [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 466.54

Ref: 3B-T4000

Staurosporine, 99+%

CAS: 62996-74-1

Staurosporine, 62996-74-1, is a cell-permeable bacterial alkyloid and protein kinase inhibitor with anti-cancer properties. Learn more at Thermo Fisher Scientific.

Formula: C₂₈H₂₆N₄O₃

Purezza: 99+%

Colore e forma: Crystalline powder or granular, White to pale cream to yellow

Peso molecolare: 466.54

Ref: 02-J62837

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purezza: 100.0%

Colore e forma: Yellow powder

Peso molecolare: 466.0

Ref: 8R-PB0005

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 466.5310

Ref: IN-DA00365L

Staurosporine

CAS: 62996-74-1

Staurosporine

Formula: C₂₈H₂₆N₄O₃

Purezza: ≥98%

Peso molecolare: 466.53

Ref: 54-BUP12221

Staurosporine, from Streptomyces sp.

CAS: 62996-74-1

Staurosporine, from Streptomyces sp.

Formula: C₂₈H₂₆N₄O₃

Purezza: 98%

Colore e forma: White to yellow Solid

Peso molecolare: 466.53103

Ref: 54-BIS0504

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Peso molecolare: 466.54

Ref: 4Z-S-172001

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Colore e forma: Neat

Peso molecolare: 466.53

Ref: 04-C16974200

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purezza: (HPLC) ≥ 98.0%

Colore e forma: Off-white to yellow solid

Peso molecolare: 466.54

Ref: 7W-GA8507

Staurosporine

CAS: 62996-74-1

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr

Formula: C₂₈H₂₆N₄O₃

Purezza: 99.24% - 99.82%

Colore e forma: Off-White Powder

Peso molecolare: 466.53

Ref: TM-T6680

Staurosporin

Prodotto controllato

CAS: 62996-74-1

Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),

Formula: C₂₈H₂₆N₄O₃

Colore e forma: Neat

Peso molecolare: 466.53

Ref: TR-S685000

Staurosporine

Prodotto controllato

CAS: 62996-74-1

Inhibitor of protein kinases; induces apoptosis; anti-cancer

Formula: C₂₈H₂₆N₄O₃

Purezza: Min. 98 Area-%

Colore e forma: Off-White Powder

Peso molecolare: 466.53 g/mol

Ref: 3D-AS27871

Staurosporine

CAS: 62996-74-1

Purezza: 98%

Peso molecolare: 466.2

Ref: 10-F795841

Staurosporine

CAS: 62996-74-1

Staurosporine is a fluorogenic substrate for the enzyme staurosporinase that is used in food testing, environmental testing, and diagnostics. It can be conjugated to an antibody or other protein to produce a ligand that binds to a receptor on the cell surface. Staurosporine has been shown to inhibit the activity of various enzymes including phospholipase A2, phospholipase C, and protein kinase C. It also inhibits bacterial DNA gyrase and topoisomerase IV. The fluorescence of staurosporine can be detected with luminometers or fluorescent microscopes.

Formula: C₂₈H₂₆N₄O₃

Purezza: Min. 95%

Peso molecolare: 466.53 g/mol

Ref: 3D-AS182928

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Peso molecolare: 466.5

Ref: ST-EA-CP-M107008