CAS 64350-24-9

N-(2-metilpropanoloil)guanosina

Descrizione:

N-(2-metilpropanoloil)guanosina è un nucleoside modificato che presenta una base di guanosina legata a un gruppo 2-metilpropanoyl. Questo composto è caratterizzato dai suoi componenti strutturali, che includono una base purinica (guanina), uno zucchero ribosio e un gruppo acile derivato dall'acido 2-metilpropanoico. La presenza del gruppo acile può influenzare la solubilità, la stabilità e l'attività biologica del composto, influenzando potenzialmente le sue interazioni con enzimi e altre biomolecole. N-(2-metilpropanoloil)guanosina può mostrare proprietà uniche rispetto alla guanosina non modificata, come affinità di legame alterate o stabilità migliorata nei sistemi biologici. Questa modifica può essere di interesse nella ricerca biochimica, in particolare negli studi che coinvolgono interazioni tra acidi nucleici, vie di segnalazione o progettazione di farmaci. Come molti derivati dei nucleosidi, le sue caratteristiche possono includere punti di fusione specifici, solubilità in vari solventi e reattività in determinate condizioni, che sono essenziali per comprendere le sue potenziali applicazioni in chimica medicinale e biologia molecolare.

Formula: C₁₄H₁₉N₅O₆

InChI: InChI=1/C14H19N5O6/c1-5(2)11(23)17-14-16-10-7(12(24)18-14)15-4-19(10)13-9(22)8(21)6(3-20)25-13/h4-6,8-9,13,20-22H,3H2,1-2H3,(H2,16,17,18,23,24)/t6-,8-,9-,13-/m1/s1

InChI key: OXTYJSXVUGJSGM-HTVVRFAVSA-N

SMILES: CC(C)C(=Nc1nc2c(c(n1)O)ncn2[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)O)O

Sinonimi:

• Guanosine, N-(2-methyl-1-oxopropyl)-
• N-(2-Methyl-1-oxopropyl)guanosine
• N2-Isobutyrylguanosine
• N-Isobutyrylguanosine
• N2-Isobutyryl-guanosine
• N2-(2-Methylpropanoyl)-Guanosine
• N2-Isobutyryl-D-guanosine
• ibu-rG
• N2-(2-METHYLPROPANOYL)-GUANOSINE USP/EP/BP
• N-{9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-methylpropanamide
• N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
• N2-ISOBUTYRYLGUANOSINE MONOHYDRATE
• N2-Isobutyrylguanosine Hydrate
• N2-iBu-Gr
• N-Isobutyryl guanosine
• N
• N2-iBu-rG
• 2
• -Isobutyrylguanosine

N2-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 353.34

Ref: 3B-I0699

N2-Isobutyrylguanosine

CAS: 64350-24-9

Ref: 7W-GN0224

N-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 353.3306

Ref: IN-DA003SNU

N2-Iso-Butyryl Guanosine

CAS: 64350-24-9

N2-Iso-Butyryl Guanosine is a nucleoside derivative suitable for biochemical experiments and drug synthesis research.

Formula: C₁₄H₁₉N₅O₆

Purezza: 99.26%

Colore e forma: White Solid

Peso molecolare: 353.3306

Ref: TM-TNU1135

N2-(2-Methylpropanoyl)guanosine

CAS: 64350-24-9

N2-(2-Methylpropanoyl)guanosine

Formula: C₁₄H₁₉N₅O₆

Purezza: 97%

Colore e forma: Solid-Powder

Peso molecolare: 353.33056

Ref: 54-OR930002

N2-Isobutyrylguanosine

CAS: 64350-24-9

N2-Isobutyrylguanosine is a synthetic nucleoside analog. It is activated by the enzyme thymidine kinase and inhibits the synthesis of RNA and DNA, which leads to cell death. N2-Isobutyrylguanosine has been shown to be an effective inhibitor of epidermal growth factor receptor (EGFR) in mammalian cells. This drug has also been shown to inhibit insulin-like growth factor I and phosphorothioate monomers. N2-Isobutyrylguanosine inhibits the synthesis of fatty acids, leading to a decrease in lipid content in cells.

Formula: C₁₄H₁₉N₅O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 353.33 g/mol

Ref: 3D-NI03488

N-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 353.335

Ref: 10-F239503

N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

CAS: 64350-24-9

N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Formula: C₁₄H₁₉N₅O₆

Purezza: 95%

Peso molecolare: 353.33

Ref: IN-DG142758

N-Isobutyrylguanosine

Prodotto controllato

CAS: 64350-24-9

Applications N-Isobutyrylguanosine is used in the syntehsis of 2'-O-(o-nitrobenzyl)-3'-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis.
References Li, N., et. al.: J. Org. Chem., 79, 3647 (2014)

Formula: C₁₄H₁₉N₅O₆

Colore e forma: Neat

Peso molecolare: 353.33

Ref: TR-I780120

N2-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Peso molecolare: 353.34

Ref: ST-EA-CP-A88079