CAS 66309-69-1

Cloridrato di cefotiam

Descrizione:

Cloridrato di cefotiam è un antibiotico cefalosporinico ad ampio spettro, utilizzato principalmente per il trattamento di varie infezioni batteriche. È caratterizzato dalla sua capacità di inibire la sintesi della parete cellulare batterica, che è un meccanismo cruciale per la sua attività antibatterica. Il composto è tipicamente somministrato per iniezione ed è efficace contro batteri Gram-positivi e Gram-negativi. Cloridrato di cefotiam è noto per la sua stabilità in presenza di beta-lattamasi, enzimi prodotti da alcuni batteri che conferiscono resistenza ad altri antibiotici. La sostanza è solubile in acqua, il che facilita il suo utilizzo in contesti clinici. La sua farmacocinetica include un rapido assorbimento e distribuzione nei tessuti corporei, con una emivita relativamente breve, che richiede più dosi per effetti terapeutici sostenuti. Gli effetti collaterali comuni possono includere disturbi gastrointestinali e reazioni allergiche, simili ad altri antibiotici. Come con qualsiasi antibiotico, si raccomanda di effettuare test di suscettibilità appropriati per garantire la sua efficacia contro patogeni specifici. In generale, Cloridrato di cefotiam è un'opzione preziosa nell'arsenale degli antibiotici, particolarmente per infezioni in cui altri trattamenti possono fallire.

Formula: C₁₈H₂₃N₉O₄S₃·2ClH

InChI: InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1

InChI key: InChIKey=BWRRTAXZCKVRON-DGPOFWGLSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4N(CCN(C)C)N=NN4)[H].Cl

Sinonimi:

• (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
• (6R-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, hydrochloride (1:2), (6R,7R)-
• Abbott 48999
• Cefotiam Dihydrichloride
• Cefotiam dihydrochloride
• Cefotiam.2HCl(Cefotiam hydrochloride)
• Ceradon
• Halospor
• Pansporin
• Pansporine
• Spizef
• Sporidyn

Cefotiam dihydrochloride

CAS: 66309-69-1

A broad spectrum antibiotic

Formula: C₁₈H₂₃N₉O₄S₃•HCl

Peso molecolare: 562.09

Ref: 02-J66529

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-

CAS: 66309-69-1

Formula: C₁₈H₂₅Cl₂N₉O₄S₃

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 598.5500

Ref: IN-DA00IBL5

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride is a third-gen cephalosporin that disrupts bacterial cell wall synthesis by inhibiting PBPs.

Formula: C₁₈H₂₃N₉O₄S₃·2HCl

Purezza: 98.23% - 99.98%

Colore e forma: Solid

Peso molecolare: 598.60

Ref: TM-T1616

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride

Purezza: ≥98%

Peso molecolare: 598.6g/mol

Ref: 54-BUP14507

Cefotiam Dihydrochloride

CAS: 66309-69-1

Cefotiam Dihydrochloride

Purezza: 98%

Peso molecolare: 598.54g/mol

Ref: 54-OR1030485

Cefotiam DiHCl

CAS: 66309-69-1

Formula: C₁₈H₂₃N₉O₄S₃·2HCl

Colore e forma: Off-White Solid

Peso molecolare: 525.63 2*36.46

Ref: 4Z-C-10302

Cefotiam dihydrochloride hydrate

CAS: 66309-69-1

Formula: C₁₈H₂₃N₉O₄S₃·2HCl·xH₂O

Purezza: ≥ 98.0%

Colore e forma: White, off-white to tan or yellow powder

Peso molecolare: 598.55 (anhydrous)

Ref: 7W-GL6662

Cefotiam Hydrochloride RS

CAS: 66309-69-1

Colore e forma: White To Pale Yellow-White

Ref: 2K-7000460021

Cefotiam Dihydrochloride

CAS: 66309-69-1

Applications Cephalosporin Antibiotic.
References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

Formula: C₁₈H₂₃N₉O₄S₃HCl

Colore e forma: White To Light Yellow

Peso molecolare: 598.55

Ref: TR-C243005

Cefotiam dihydrochloride

CAS: 66309-69-1

Cefotiam dihydrochloride is a semisynthetic antibiotic that belongs to the class of cephalosporin antibiotics. It inhibits bacterial growth by binding to penicillin-binding proteins and blocking cell wall synthesis. Cefotiam has been shown to be effective against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, and Clostridium perfringens. This drug is used in the treatment of infectious diseases caused by Gram-positive bacteria, including meningitis, endocarditis, osteomyelitis, and peritonitis. The intravenous injection of cefotiam has been shown to be safe and well tolerated in adults with septicemia or bacteremia. Cefotiam is excreted unchanged in the urine.

Formula: C₁₈H₂₅Cl₂N₉O₄S₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 598.55 g/mol

Ref: 3D-FC19863

Cefotiam hydrochloride

CAS: 66309-69-1

Purezza: 98%

Peso molecolare: 598.54

Ref: 10-F979609

Cefotiam Dihydrochloride-13C, 15N2

Prodotto controllato

CAS: 61622-34-2, 66309-69-1

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Formula: C₁₇CH₂₃N₇N₂O₄S₃•2x(HCl)

Colore e forma: Neat

Peso molecolare: 601.5295

Ref: TR-C243007

Cefotiam Hydrochloride (DISCONTINUED)

CAS: 66309-69-1

Antibiotics nesoi

Formula: C₁₈H₂₃N₉O₄S₃·2ClH

Colore e forma: Crystals

Peso molecolare: 598.55

Ref: 45-1098005