CAS 66701-25-5

trans-Eposisuccinil-L-leucilamido-(4-guanidino)butano

Descrizione:

trans-Eposisuccinil-L-leucilamido-(4-guanidino)butano, identificato dal suo numero CAS 66701-25-5, è un composto sintetico che presenta caratteristiche tipiche delle strutture simili ai peptidi. Questa sostanza presenta un gruppo funzionale epossido, che contribuisce alla sua reattività, in particolare nei sistemi biologici dove può interagire con nucleofili. La presenza di un gruppo guanidino suggerisce una potenziale attività biologica, poiché i composti guanidini sono spesso coinvolti nell'inibizione o modulazione delle enzimi. Il componente L-leucilamido indica che deriva dall'aminoacido leucina, il che può influenzare la sua interazione con recettori biologici o enzimi. Inoltre, la struttura complessiva suggerisce che potrebbe possedere proprietà rilevanti per la chimica medicinale, in particolare nello sviluppo di agenti terapeutici mirati a specifiche vie biologiche. La sua stabilità, solubilità e reattività dipenderebbero dalle condizioni circostanti, come pH e temperatura, rendendolo un composto di interesse per ulteriori ricerche in farmacologia e biochimica.

Formula: C₁₅H₂₇N₅O₅

InChI: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1

InChI key: InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N

SMILES: C(N[C@H](C(NCCCCNC(=N)N)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

Sinonimi:

• (2R,3R)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• (2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
• (2S,3S)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• E 64 (proteinase inhibitor)
• E-64
• E-64 Protease Inhibitor
• E64
• Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-
• Proteinase inhibitor E 64
• trans-Epoxysuccinyl-<span class="text-smallcaps">L</span>-leucylamido-(4-guanidino)butane
• trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

E-64

CAS: 66701-25-5

Selective and irreversible cysteine protease inhibitor

Formula: C₁₅H₂₇N₅O₅

Colore e forma: White to pale cream, Crystals or powder or crystalline powder

Peso molecolare: 357.4

Ref: 02-J62933

L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide

CAS: 66701-25-5

Most commonly used diagnostic inhibitor for the characterization of cysteine proteinases. Originally isolated from cultures of Aspergillus japonicus, E64 is a non-competitive, irreversible inhibitor of thiol proteinases of the papain and calpain families.

Formula: C₁₅H₂₇N₅O₅

Purezza: 99.7%

Peso molecolare: 357.41

Ref: 01-4027910

E-64

CAS: 66701-25-5

E-64

Formula: C₁₅H₂₇N₅O₅

Purezza: 99%

Colore e forma: White Solid

Peso molecolare: 357.40538

Ref: 54-BIMI2157

E-64 protease inhibitor

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White crystalline powder

Peso molecolare: 357.40

Ref: 7W-GL4130

E-64

CAS: 66701-25-5

E-64

Formula: C₁₅H₂₇N₅O₅

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 732.837

Ref: 54-BUP13066

E-64

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 357.4054

Ref: IN-DA0036TL

E 64

Prodotto controllato

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Colore e forma: Neat

Peso molecolare: 357.41

Ref: TR-E100490

E-64

CAS: 66701-25-5

E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.

Formula: C₁₅H₂₇N₅O₅

Purezza: 98% - 99.95%

Colore e forma: Solid

Peso molecolare: 357.4054

Ref: TM-T6037

E-64

CAS: 66701-25-5

(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid

Formula: C₁₅H₂₇N₅O₅

Purezza: 99%

Peso molecolare: 357.41

Ref: IN-DG46729

E-64

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Peso molecolare: 357.41

Ref: 4Z-E-189001

E-64

CAS: 66701-25-5

E-64 is a chemical inhibitor that binds to the ATP synthase in mitochondria, inhibiting oxidative phosphorylation. This inhibition of mitochondrial energy production leads to cell death by apoptosis. E-64 has been shown to inhibit tumor growth in vitro and in vivo by inducing autophagy and inhibiting cancer cell proliferation. E-64 has also been shown to have proteolytic activity against serum proteins, which may be due to its ability to bind to the phosphate groups of proteins.

Formula: C₁₅H₂₇N₅O₅H₂O

Purezza: Min. 95%

Peso molecolare: 366.42 g/mol

Ref: 3D-IES-4096

E-64

CAS: 66701-25-5

Inhibitor of cathepsins and other cysteine proteases

Formula: C₁₅H₂₇N₅O₅

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 357.41 g/mol

Ref: 3D-FE29621

E-64

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Peso molecolare: 357.41

Ref: BE-RMCE210000

E 64-d8

Prodotto controllato

CAS: 66701-25-5

Formula: C₁₅D₈H₁₉N₅O₅

Colore e forma: Neat

Peso molecolare: 365.455

Ref: TR-E100492

E-64

CAS: 66701-25-5

E-64 is a research tool that is used to study protein interactions. It has been shown to inhibit ion channels, such as the nicotinic acetylcholine receptor and the voltage-gated calcium channel. E-64 binds to receptors in the cell membrane, blocking ion channels and altering intracellular signaling pathways. E-64 has been shown to inhibit nitric oxide synthase, which may account for its anti-inflammatory properties. E-64 also inhibits an enzyme called protein tyrosine phosphatase 1B (PTP1B), which is involved in insulin resistance and type 2 diabetes mellitus.

Formula: C₁₅H₂₇N₅O₅

Purezza: Min. 95%

Peso molecolare: 357.41 g/mol

Ref: 3D-IES-4096-V