CAS 671204-98-1

Acetamide, N-[(3R)-1-[(6-fluoro-2-naphthalenyl)methyl]-3-pyrrolidinyl]-2-[1-[(3-methyl-1-oxido-2-pyridinyl)carbonyl]-4-piperidinylidene]-

Formula: C₂₉H₃₁FN₄O₃

Sinonimi:

• Acetamide, N-[(3R)-1-[(6-fluoro-2-naphthalenyl)methyl]-3-pyrrolidinyl]-2-[1-[(3-methyl-1-oxido-2-pyridinyl)carbonyl]-4-piperidinylidene]-

YM-344031

CAS: 671204-98-1

YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC₅₀ values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.

Formula: C₂₉H₃₁FN₄O₃

Peso molecolare: 502.58

Ref: TM-T88324