CAS 7177-50-6

Nafcillina sodica monoidrato

Descrizione:

Nafcillina sodica monoidrato è un antibiotico penicillina semisintetico, utilizzato principalmente per trattare infezioni causate da stafilococchi produttori di penicilinasi. È caratterizzato dalla sua capacità di resistere alla degradazione da parte di alcune beta-lattamasi, rendendolo efficace contro ceppi batterici specifici. Il composto appare come una polvere cristallina bianca a bianco sporco ed è solubile in acqua, il che facilita la sua somministrazione per iniezione. La sua struttura molecolare include un anello beta-lattamico, un anello di tiazolidina e un ione sodio, contribuendo alle sue proprietà antibatteriche. Nafcillina sodica monoidrato viene tipicamente somministrato per via endovenosa o intramuscolare, e la sua farmacocinetica comporta una rapida distribuzione nei tessuti corporei, con una emivita relativamente breve. Gli effetti collaterali comuni possono includere reazioni allergiche, disturbi gastrointestinali e potenziale nefrotossicità. Come con altri antibiotici, è essenziale utilizzare Nafcillina sodica monoidrato in modo giudizioso per prevenire lo sviluppo di resistenza agli antibiotici. Nel complesso, rimane un'opzione critica nel trattamento di alcune infezioni batteriche, in particolare quelle causate da ceppi resistenti.

Formula: C₂₁H₂₃N₂NaO₆S

InChI: InChI=1/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1

InChI key: InChIKey=RKBDQTFFBRQMPN-KMFBOIRUSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C4=C(C=CC3OCC)C=CC=C4)C2=O)(SC1(C)C)[H].[Na].O

Sinonimi:

• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S-(2alpha,5alpha,6beta))
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
• Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate monohydrate
• Nafcil
• Nafcillin natrium-1-wasser
• Nafcillin sodium salt monohydrate
• Sodium 6-(2-ethoxy-1-naphthamido)penicillanate monohydrate
• Sodium nafcillin monohydrate
• Unii-49G3001Bck
• Wy 3277
• sodium (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• Nafcillin monohydrate sodium salt
• NAFCILLINSODIUMSTERILE
• Sodium (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• nafcillin sodium

Nafcillin Sodium

CAS: 7177-50-6

Penicillins and their derivatives with a penicillanic acid structure and salts thereof, nesoi

Formula: C₂₁H₂₁N₂NaO₅S·H₂O

Colore e forma: White Light Yellow Crystalline Powder

Peso molecolare: 454.11745

Ref: 45-1450007

Nafcillin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate (CL 8491) is a semi-synthetic naphthalene, nafcillin inhibits bacterial wall synthesis by a mechanism similar to penicillin.

Formula: C₂₁H₂₁N₂O₅SNa·H₂O

Purezza: 96.62%

Colore e forma: White Powder

Peso molecolare: 454.47

Ref: TM-T1312

(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium hydrate

CAS: 7177-50-6

Formula: C₂₁H₂₃N₂NaO₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 454.4719

Ref: IN-DA0062G3

Nafcillin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate

Purezza: ≥90%

Peso molecolare: 454.47g/mol

Ref: 54-BUP15832

Nafcillin sodium salt monohydrate

CAS: 7177-50-6

Nafcillin sodium salt monohydrate

Purezza: 98%(Contain 2-3% ethyl acetate)

Peso molecolare: 454.47g/mol

Ref: 54-OR1028266

Nafcillin sodium monohydrate 100 µg/mL in Acetonitrile

CAS: 7177-50-6

Formula: C₂₁H₂₁N₂O₅S·Na·H₂O

Colore e forma: Single Solution

Peso molecolare: 454.47

Ref: 04-A15402500AL-100

Nafcillin sodium salt monohydrate

CAS: 7177-50-6

Formula: C₂₁H₂₁N₂O₅SNa·H₂O

Purezza: ≥ 98.5% (anhydrous basis)

Colore e forma: White to yellow crystalline powder or crystals

Peso molecolare: 454.47

Ref: 7W-GA3972

Sodium Nafcillin Monohydrate

CAS: 7177-50-6

Applications Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria.
References Taboada, P. et al.: Langmuir. 16, 3175 (2000);

Formula: C₂₁H₂₁N₂O₅S·Na·H₂O

Colore e forma: Off-White

Peso molecolare: 454.47

Ref: TR-S645800

Nafcilllin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate is a beta-lactam antibiotic, which is derived from the penicillin class of antimicrobials. It is specifically a semi-synthetic penicillin and is commonly sourced through chemical synthesis to enhance its stability and spectrum of activity. Nafcillin primarily exerts its bactericidal effects by inhibiting bacterial cell wall synthesis. It achieves this through its strong affinity for penicillin-binding proteins (PBPs), which are essential for maintaining the bacterial cell wall structure. By disrupting the formation of peptidoglycan cross-links, nafcillin effectively weakens the bacterial cell wall, leading to cell lysis and death, especially in gram-positive bacteria such as Staphylococcus aureus, including methicillin-sensitive strains (MSSA).

Formula: C₂₁H₂₁N₂O₅SNa·H₂O

Purezza: Min. 95%

Colore e forma: White to off-white solid.

Peso molecolare: 454.47 g/mol

Ref: 3D-AN61452

Nafcillin Sodium hydrate

CAS: 7177-50-6

Formula: C₂₁H₂₂N₂O₅SNaH₂O

Peso molecolare: 414.5 : 23.0 : 18.0

Ref: ST-EA-CP-N68001