CAS 78832-65-2

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina

Descrizione:

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina, con il numero CAS 78832-65-2, è un derivato peptidico sintetico che incorpora sia sequenze di amminoacidi che un moiety a base di furanos. Questo composto presenta una struttura unica che combina le proprietà di un peptide con quelle di un acrilamide, il che può conferire reattività specifica e attività biologica. La presenza dell'anello di furanos suggerisce un potenziale per interazioni con sistemi biologici, influenzando possibilmente le sue proprietà farmacologiche. I componenti amminoacidici—L-leucina, glicina, L-prolina e L-alanina—contribuiscono alla stabilità e solubilità del composto, influenzando anche le sue caratteristiche conformazionali. Tali peptidi possono mostrare varie attività biologiche, inclusi effetti antimicrobici, anticancro o inibitori di enzimi, a seconda della loro struttura e delle interazioni specifiche in cui sono coinvolti. In generale, questo composto rappresenta un'affascinante intersezione tra chimica organica e biochimica, con potenziali applicazioni nello sviluppo di farmaci e nella ricerca terapeutica.

Formula: C₂₃H₃₂N₄O₇

InChI: InChI=1/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

InChI key: ZLFQNOJSYZSINX-PVJKAEHXSA-N

SMILES: C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)/C=C/C2=CC=CO2

Sinonimi:

• N-(3-(2-furyl)acryloyl)-leu-gly-pro-ala
• FA-Leu-Gly-Pro-Ala-OH
• Falgpa
• N-[(2E)-3-furan-2-ylprop-2-enoyl]-L-leucylglycyl-L-prolyl-L-alanine
• COLLAGENASE CELL PREPARATION GRADE
• COLLAGENASE GRADE II
• COLLAGENASE GRADE I
• clostridiopeptidase
• CollagenaseⅡ
• N-[3-(2-FURYL)ACRYLOYL]-L-LEUCYL-GLYCYL-L-PROLYL-L-ALANINE
• (2S)-3-{2-[(1E)-2-{[(1S)-1-({2-[(2S)-2-{[(1S)-1-carboxyethyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}carbamoyl)-3-methylbutyl]carbamoyl}eth-1-en-1-yl]-1λ3-furan-1-yl}-2-{[(2S)-1-{2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-4-methylpentanamido]acetyl}pyrro
• N-[3-(2-furyl)acryloyl]-leucine-glycine-proline-alanine
• N-(3-(2-FURYL)ACRYLOYL)-L-LEUCYL-GLYCYL&
• N-{3-(2-Furyl)acryloyl}-L-leucine-glycyl-L-propyl-L-alanine
• FALGPA, N-[3-(2-Furyl)acryloyl]-L-leucyl-glycyl-L-prolyl-L-alanine
• COLLAGENASE SUBSTRATE II
• COLLAGENASE HIGHLY PURIFIED
• CollagenaseⅠ
• CollagenaseⅤ
• CollagenaseⅣ
• 2-furanacryloyl-leucyl-glycyl-prolyl-alanine
• COLLAGENASE (CLOSTRIDIOPEPTIDASE A)

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

Substrate for a versatile, convenient, continuously recording spectrophotometric assay of collagenase.

Formula: C₂₃H₃₂N₄O₇

Purezza: 97.7%

Colore e forma: Beige

Peso molecolare: 476.53

Ref: 01-4006713

FALGPA

CAS: 78832-65-2

FALGPA

Formula: C₂₃H₃₂N₄O₇

Purezza: By hplc: >98% by area (Typical Value in Batch COA)

Colore e forma: White Solid-Powder

Peso molecolare: 476.52277

Ref: 54-BIF0744

FA-Leu-Gly-Pro-Ala-O

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a synthetic peptide and a specific collagenase substrate, widely used in biochemical experiments and drug synthesis research.

Formula: C₂₃H₃₂N₄O₇

Purezza: 99.90%

Colore e forma: Solid

Peso molecolare: 476.52

Ref: TM-T205939

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

CAS: 78832-65-2

Formula: C₂₃H₃₂N₄O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 476.5228

Ref: IN-DA005DFG

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

Formula: C₂₃H₃₂N₄O₇

Purezza: 98%

Peso molecolare: 476.52

Ref: IN-DG129969

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a gelatinase inhibitor that inhibits the action of collagenase, an enzyme that breaks down collagen. It has been shown to inhibit the growth of cancer cells in vitro and may be useful as a therapeutic agent against skin cancer. FA-Leu-Gly-Pro-Ala-OH binds to the active site of the enzyme and blocks its catalytic activity by preventing proton transfer during the hydrolysis of peptide bonds. This inhibitor also has proteolytic properties, which are due to its ability to cleave proteins with basic amino acids such as arginine and lysine. The inhibitory effects of FA-Leu-Gly-Pro-Ala-OH on histological analysis were also tested on fibroblast cells with collagenase activity, which showed a significant reduction in enzyme activity after incubation with this inhibitor.

Formula: C₂₃H₃₂N₄O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 476.52 g/mol

Ref: 3D-FF110857