CAS 78919-13-8

Iloprost

Descrizione:

Iloprost è un analogo sintetico della prostaciclina (PGI2), utilizzato principalmente per le sue proprietà vasodilatatorie e antiaggreganti piastrinici. È caratterizzato dalla sua capacità di imitare gli effetti della prostaciclina naturale, portando al rilassamento della muscolatura liscia vascolare e all'inibizione dell'attivazione piastrinica. Iloprost viene tipicamente somministrato per inalazione o per via endovenosa ed è utilizzato nel trattamento dell'ipertensione arteriosa polmonare e di altre condizioni che richiedono vasodilatazione. La sostanza ha una emivita relativamente breve, richiedendo infusione continua o dosi multiple per effetti terapeutici sostenuti. La sua struttura chimica include un sistema di anelli biciclici, che contribuisce alla sua attività biologica. Iloprost è noto per i suoi effetti collaterali, che possono includere mal di testa, arrossamento e disturbi gastrointestinali. A causa dei suoi potenti effetti sul sistema cardiovascolare, è essenziale un attento monitoraggio durante il trattamento. In generale, Iloprost rappresenta un'opzione terapeutica significativa nella gestione delle condizioni associate a un flusso sanguigno compromesso e disfunzione vascolare.

Formula: C₂₂H₃₂O₄

InChI: InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1

InChI key: InChIKey=HIFJCPQKFCZDDL-ACWOEMLNSA-N

SMILES: C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]

Sinonimi:

• (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane
• (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic acid
• (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• (5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• Ciloprost
• Endoprost
• Ilomedin
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-, (5E)-
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)-
• Zk 36374

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

CAS: 78919-13-8

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

Formula: C₂₂H₃₂O₄

Purezza: 98%

Peso molecolare: 360.49

Ref: 54-OR1062959

ILOPROST

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Purezza: 98%

Colore e forma: Liquid

Peso molecolare: 360.4871

Ref: IN-DA0054KQ

Iloprost

CAS: 78919-13-8

Stability Light and Temperature Sensitive
Applications A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
References Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008); Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997); Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995);

Formula: C₂₂H₃₂O₄

Colore e forma: Neat

Peso molecolare: 360.49

Ref: TR-I267300

Iloprost

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Peso molecolare: 360.49

Ref: 4Z-I-098001

Iloprost

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Peso molecolare: 360.5

Ref: BE-RMCI029000

Iloprost

CAS: 78919-13-8

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

Formula: C₂₂H₃₂O₄

Purezza: 98%

Peso molecolare: 360.49

Ref: IN-DG134341

Iloprost

CAS: 78919-13-8

Purezza: 99%

Peso molecolare: 360.494

Ref: 10-F979607

Iloprost

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Peso molecolare: 360.49

Ref: ST-EA-CP-I58000

Iloprost

CAS: 78919-13-8

Iloprost is a cyclase inhibitor that is used to treat pulmonary hypertension. It relaxes the smooth muscle cells in the lungs, which causes an increase in blood flow and oxygen levels to the heart and other organs. Iloprost also decreases the production of PGE2 and lowers blood pressure. Iloprost has been shown to be effective in treating chronic viral hepatitis and pulmonary diseases such as primary pulmonary hypertension. This drug can cause hypotension, so it should not be taken by patients with low blood pressure or those who are taking other drugs that can cause hypotension.

Formula: C₂₂H₃₂O₄

Purezza: Min. 95%

Colore e forma: Solidified Mass

Peso molecolare: 360.49 g/mol

Ref: 3D-FH24541

Iloprost

CAS: 78919-13-8

Iloprost (Ciloprost) is an inhibitor of platelet aggregation and vasodilatation used in the study of cardiovascular disease.

Formula: C₂₂H₃₂O₄

Colore e forma: Transparent Liquid

Peso molecolare: 360.49

Ref: TM-T15560