CAS 79902-63-9
:Simvastatina
Descrizione:
Simvastatina è un agente sintetico riduttore dei lipidi appartenente alla classe delle statine, utilizzato principalmente per gestire l'iperlipidemia e ridurre il rischio di malattie cardiovascolari. La sua struttura chimica presenta un anello di lattone e un gruppo acido idrossilico, che sono cruciali per la sua attività biologica. La sostanza agisce inibendo la HMG-CoA reduttasi, un enzima coinvolto nella biosintesi del colesterolo nel fegato, riducendo così i livelli di colesterolo a bassa densità (LDL) e trigliceridi, mentre aumenta moderatamente il colesterolo a alta densità (HDL). Simvastatina è tipicamente somministrato per via orale ed è noto per la sua relativamente alta biodisponibilità, sebbene subisca un ampio metabolismo di primo passaggio nel fegato. Gli effetti collaterali comuni possono includere dolore muscolare, anomalie degli enzimi epatici e disturbi gastrointestinali. È importante monitorare la funzione epatica e la salute muscolare durante il trattamento. Simvastatina è spesso prescritto insieme a modifiche dello stile di vita, come dieta ed esercizio, per migliorare i suoi effetti riduttori del colesterolo. Come con tutti i farmaci, è essenziale utilizzare Simvastatina sotto la guida di un professionista sanitario.
Formula:C25H38O5
InChI:InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21?,23?/m0/s1
InChI key:InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]
Sinonimi:- (+)-Simvastatin
- Apo-Simva
- Apo-Simvastatin
- Bestatin 20
- Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*,4S*),8aβ]]-
- Cholestat
- Co-Simvastatin
- Denan
- Egilipid
- Eucor
- Kolestevan
- L 644128-000U
- Lipex
- Lipinorm
- Liponorm
- Lipovas
- Lodales
- Lycostatin
- Mk 733
- Modutrol
- Nor-Vastina
- Novo-Simvastatin
- Pms-simvastatin
- Rechol
- Simastin 20
- Simcor
- Simcovas
- Simgal
- Simi 20
- Simlip
- Simlip 20
- Simlo 20
- Simlup 20
- Simovil
- Simratio
- Simvacard
- Simvachol
- Simvacor
- Simvahexal
- Simvas
- Simvastatin lactone
- Simvasterol
- Simvastol
- Simvofix
- Simvotin
- Sinvacor
- Sinvascor
- Sivastin
- Starstat 20
- Statin
- Synvinolin
- Valemia
- Vasilip
- Vastan
- Vazilip
- Velostatin
- Ximve
- Zocor
- Zocor Forte
- Zocord
- Zorced
- Zosta
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
- [(3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
- (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
- Simvastatin USP23,24
- SIMVASTATIN,USP
- mk-0733
- butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy
- 2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
- l644128-000u
- SimvastatineUsp25
- SIMVASTATIN USP24
- (1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
- Zocor, MK-733, Liponorm
- SimvastatinC25H3805
- 7-beta,8-beta(2s*,4s*),8a-beta))-alph
- 2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester
- Vedi altri sinonimi
Ordinare per
Purezza (%)
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19 prodotti.
Simvastatin
CAS:Formula:C25H38O5Purezza:>97.0%(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:418.57Simvastatin
CAS:SimvastatinFormula:C25H38O5Purezza:99.7%Colore e forma:Off-WhitePeso molecolare:418.27192SIMVASTATIN CRS
CAS:SIMVASTATIN CRSFormula:C25H38O5Colore e forma:Crystalline Powder. White. Powder., Crystalline Powder. White. Powder.Peso molecolare:418.5662Simvastatin
CAS:Aromatic lactones used as drugsFormula:C25H38O5Colore e forma:PowderPeso molecolare:418.56 g/mol(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
CAS:Formula:C25H38O5Purezza:98%Colore e forma:SolidPeso molecolare:418.5662Simvastatin
CAS:Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.Formula:C25H38O5Purezza:98.54% - 99.13%Colore e forma:SolidPeso molecolare:418.57Ref: TM-T0687
10mg40,00€25mg55,00€50mg65,00€100mg101,00€200mg133,00€500mg256,00€1mL*10mM (DMSO)44,00€Simvastatin
CAS:Formula:C25H38O5Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:418.57Simvastatin 100 µg/mL in Acetonitrile
CAS:Formula:C25H38O5Colore e forma:Single SolutionPeso molecolare:418.57Simvastatin
CAS:Prodotto controllatoApplications Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Formula:C25H38O5Colore e forma:White To Off-WhitePeso molecolare:418.57Simvastatin - Bio-X ™
CAS:Simvastatin is a lipid-lowering agent that belongs to the group of statins. It is prescribed for the treatment of hypercholesterolemia, coronary heart diseases, and other conditions related to high cholesterol levels. Simvastatin inhibits the production of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in the synthesis of cholesterol. Simvastatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C25H38O5Purezza:(%) Min. 95%Colore e forma:PowderPeso molecolare:418.57 g/molSimvastatin
CAS:HMG-CoA reductase inhibitor
Formula:C25H38O5Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:418.57 g/molSimvastatin
CAS:M03997 - Simvastatin
Formula:C25H38O5Purezza:98%Colore e forma:SolidPeso molecolare:418.574
![(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydr…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0032AJ.jpg&w=3840&q=75)
