CAS 79902-63-9

Simvastatina

Descrizione:

Simvastatina è un agente sintetico riduttore dei lipidi appartenente alla classe delle statine, utilizzato principalmente per gestire l'iperlipidemia e ridurre il rischio di malattie cardiovascolari. La sua struttura chimica presenta un anello di lattone e un gruppo acido idrossilico, che sono cruciali per la sua attività biologica. La sostanza agisce inibendo la HMG-CoA reduttasi, un enzima coinvolto nella biosintesi del colesterolo nel fegato, riducendo così i livelli di colesterolo a bassa densità (LDL) e trigliceridi, mentre aumenta moderatamente il colesterolo a alta densità (HDL). Simvastatina è tipicamente somministrato per via orale ed è noto per la sua relativamente alta biodisponibilità, sebbene subisca un ampio metabolismo di primo passaggio nel fegato. Gli effetti collaterali comuni possono includere dolore muscolare, anomalie degli enzimi epatici e disturbi gastrointestinali. È importante monitorare la funzione epatica e la salute muscolare durante il trattamento. Simvastatina è spesso prescritto insieme a modifiche dello stile di vita, come dieta ed esercizio, per migliorare i suoi effetti riduttori del colesterolo. Come con tutti i farmaci, è essenziale utilizzare Simvastatina sotto la guida di un professionista sanitario.

Formula: C₂₅H₃₈O₅

InChI: InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21?,23?/m0/s1

InChI key: InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N

SMILES: O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Sinonimi:

• (+)-Simvastatin
• Apo-Simva
• Apo-Simvastatin
• Bestatin 20
• Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*,4S*),8aβ]]-
• Cholestat
• Co-Simvastatin
• Denan
• Egilipid
• Eucor
• Kolestevan
• L 644128-000U
• Lipex
• Lipinorm
• Liponorm
• Lipovas
• Lodales
• Lycostatin
• Mk 733
• Modutrol
• Nor-Vastina
• Novo-Simvastatin
• Pms-simvastatin
• Rechol
• Simastin 20
• Simcor
• Simcovas
• Simgal
• Simi 20
• Simlip
• Simlip 20
• Simlo 20
• Simlup 20
• Simovil
• Simratio
• Simvacard
• Simvachol
• Simvacor
• Simvahexal
• Simvas
• Simvastatin lactone
• Simvasterol
• Simvastol
• Simvofix
• Simvotin
• Sinvacor
• Sinvascor
• Sivastin
• Starstat 20
• Statin
• Synvinolin
• Valemia
• Vasilip
• Vastan
• Vazilip
• Velostatin
• Ximve
• Zocor
• Zocor Forte
• Zocord
• Zorced
• Zosta
• Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
• [(3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
• Simvastatin USP23,24
• SIMVASTATIN,USP
• mk-0733
• butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy
• 2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
• l644128-000u
• SimvastatineUsp25
• SIMVASTATIN USP24
• (1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
• Zocor, MK-733, Liponorm
• SimvastatinC25H3805
• 7-beta,8-beta(2s*,4s*),8a-beta))-alph
• 2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER
• Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester

Simvastatin

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Purezza: >97.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 418.57

Ref: 3B-S0509

SIMVASTATIN FOR SYSTEM SUITABILITY CRS

CAS: 79902-63-9

SIMVASTATIN FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002069

Simvastatin

CAS: 79902-63-9

Simvastatin

Formula: C₂₅H₃₈O₅

Purezza: 99.7%

Colore e forma: Off-White

Peso molecolare: 418.27192

Ref: 47-739

SIMVASTATIN CRS

CAS: 79902-63-9

SIMVASTATIN CRS

Formula: C₂₅H₃₈O₅

Colore e forma: Added Modified

Peso molecolare: 418.5662

Ref: 41-S0650000

Simvastatin

CAS: 79902-63-9

Aromatic lactones used as drugs

Formula: C₂₅H₃₈O₅

Colore e forma: Powder

Peso molecolare: 418.56 g/mol

Ref: 45-1612700

Simvastatin

CAS: 79902-63-9

Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.

Formula: C₂₅H₃₈O₅

Purezza: 98.54% - 99.88%

Colore e forma: Solid

Peso molecolare: 418.5662

Ref: TM-T0687

Simvastatin

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 418.5662

Ref: IN-DA0032AJ

Simvastatin

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 418.57

Ref: 4Z-S-124

Simvastatin

CAS: 79902-63-9

Simvastatin

Formula: C₂₅H₃₈O₅

Purezza: ≥98%

Peso molecolare: 418.57

Ref: 54-BUP17155

Simvastatin

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 418.57

Ref: 7W-GP4505

Simvastatin (Standard)

CAS: 79902-63-9

Simvastatin (Standard) is a reference standard of the HMG-CoA reductase inhibitor simvastatin.

Formula: C₂₅H₃₈O₅

Purezza: 98.3%

Peso molecolare: 418.5662

Ref: TM-TMSM-2087

Simvastatin

Prodotto controllato

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Colore e forma: Neat

Peso molecolare: 418.57

Ref: 04-C16970100

Simvastatin 100 µg/mL in Acetonitrile

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Colore e forma: Single Solution

Peso molecolare: 418.57

Ref: 04-A16970100AL-100

Simvastatin

Prodotto controllato

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Colore e forma: Neat

Peso molecolare: 418.57

Ref: 86-MM0158.00

Simvastatin

Prodotto controllato

CAS: 79902-63-9

Applications Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),

Formula: C₂₅H₃₈O₅

Colore e forma: Neat

Peso molecolare: 418.57

Ref: TR-S485000

Simvastatin

CAS: 79902-63-9

(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

Formula: C₂₅H₃₈O₅

Purezza: 98%

Peso molecolare: 418.57

Ref: IN-DG151199

Simvastatin RS

CAS: 79902-63-9

Colore e forma: White

Ref: 2K-107150002

Simvastatin

CAS: 79902-63-9

Formula: C₂₅H₃₈O₅

Peso molecolare: 418.57

Ref: ST-EA-CP-S4000

Simvastatin - Bio-X ™

CAS: 79902-63-9

Simvastatin is a lipid-lowering agent that belongs to the group of statins. It is prescribed for the treatment of hypercholesterolemia, coronary heart diseases, and other conditions related to high cholesterol levels. Simvastatin inhibits the production of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in the synthesis of cholesterol. Simvastatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₅H₃₈O₅

Purezza: (%) Min. 95%

Colore e forma: Powder

Peso molecolare: 418.57 g/mol

Ref: 3D-BS164407

Simvastatin

CAS: 79902-63-9

HMG-CoA reductase inhibitor

Formula: C₂₅H₃₈O₅

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 418.57 g/mol

Ref: 3D-FS27832