CAS 841290-81-1

Formula: C28H29FN6O8S

InChI: InChI=1S/C22H23FN6O5.C6H6O3S/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4;7-10(8,9)6-4-2-1-3-5-6/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30);1-5H,(H,7,8,9)

InChI key: UXDRJPYSTZHIOE-UHFFFAOYSA-N

SMILES: CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O

R406

CAS: 841290-81-1

Formula: C₂₈H₂₉FN₆O₈S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 628.6287

Ref: IN-DA00G3PP

R406

CAS: 841290-81-1

R406

Formula: C₂₂H₂₃FN₆O₅·C₆H₆O₃S

Purezza: ≥95%

Colore e forma: Solid

Peso molecolare: 628.63

Ref: 54-BUP04252

6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-2H-Pyrido[3,2-b][1,4]Oxazin-3(4H)-One Benzenesulfonate

CAS: 841290-81-1

6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-2H-Pyrido[3,2-b][1,4]Oxazin-3(4H)-One Benzenesulfonate

Formula: C₂₈H₂₉FN₆O₈S

Purezza: 98%

Peso molecolare: 628.63

Ref: 54-PC108892

R406

CAS: 841290-81-1

Applications R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).
References Borge, M. et al.: J. Immunol., 193, 3165 (2014); Kimura, Y. et al.: J. Biol. Chem., 289, 31565 (2014);

Formula: C₂₂H₂₃FN₆O₅·(C₆H₆O₃S)

Colore e forma: Neat

Peso molecolare: 628.6

Ref: TR-R060000

R406

CAS: 841290-81-1

R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.

Formula: C₂₈H₂₉FN₆O₈S

Purezza: 97.67% - 98.88%

Colore e forma: White Solid

Peso molecolare: 628.629

Ref: TM-T6174

R406

CAS: 841290-81-1

6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate

Formula: C₂₈H₂₉FN₆O₈S

Purezza: 98%

Peso molecolare: 628.63

Ref: IN-DG448256

R 406

CAS: 841290-81-1

Inhibitor of SYK kinase

Formula: C₂₂H₂₃FN₆O₅•C₆H₆O₃S

Purezza: Min. 95%

Peso molecolare: 628.63 g/mol

Ref: 3D-FR103901