CAS 86639-52-3

7-etil-10-idrossicamptotecina

Descrizione:

7-etil-10-idrossicamptotecina, con il numero CAS 86639-52-3, è un derivato della camptotecina, un composto originariamente isolato dalla corteccia dell'albero cinese Camptotheca acuminata. Questa sostanza è caratterizzata dalle sue modifiche strutturali, che migliorano le sue proprietà farmacologiche. Mostra una potente attività antitumorale, principalmente attraverso il suo meccanismo d'azione come inibitore della topoisomerasi I, interrompendo i processi di replicazione e trascrizione del DNA nelle cellule tumorali. Il composto è tipicamente un solido giallo pallido ed è solubile in solventi organici come il dimetilsolfossido (DMSO), ma ha una solubilità limitata in acqua. Il suo potenziale terapeutico è stato esplorato in vari trattamenti contro il cancro, in particolare per i tumori solidi. Tuttavia, come molti agenti chemioterapici, può presentare effetti collaterali, inclusa la tossicità per le cellule normali. La ricerca continua a ottimizzare la sua efficacia e a minimizzare gli effetti avversi, rendendolo un argomento di interesse in chimica medicinale e oncologia.

Formula: C₂₂H₂₀N₂O₅

InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI key: InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N

SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5

Sinonimi:

• (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-Sn 38
• 10-Hydroxy-7-ethylcamptothecin
• 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-
• 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 7-Ethyl-10-Hydroxy Camptothecin
• 7-Ethyl-10-Hydroxy-Camptothecine
• 7-Ethyl-10-hydroxy-20(S)-camptothecin
• 7-Ethyl-10-hydroxycamptothecine
• Intermediate of Irinotecan 1
• SN 38 (pharmaceutical)
• SN 38 lactone
• Sn-38

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Yellow to Green powder to crystal

Peso molecolare: 392.41

Ref: 3B-E0748

Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 86639-52-3

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Formula: C₂₂H₂₀N₂O₅

Colore e forma: Yellow Off-White Powder

Peso molecolare: 392.13722

Ref: 45-1347631

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Purezza: ≥ 98.0%

Colore e forma: Off-white to yellow powder

Peso molecolare: 392.40

Ref: 7W-GP6652

Irinotecan EP Impurity E (Irinotecan USP Related Compound B, (S)-7-Ethyl-10-Hydroxy Camptothecin)

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Colore e forma: Pale Yellow Solid

Peso molecolare: 392.41

Ref: 4Z-I-1818

SN-38

CAS: 86639-52-3

SN-38

Purezza: ≥98%

Peso molecolare: 392.4g/mol

Ref: 54-BUP14103

7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 86639-52-3

Colore e forma: Neat

Ref: 86-MM1157.01

7-Ethyl-10-Hydroxycamptothecin

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Purezza: 95%~99%

Peso molecolare: 392.411

Ref: BP-BP0099

SN-38

CAS: 86639-52-3

SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).

Formula: C₂₂H₂₀N₂O₅

Purezza: 98% - 99.97%

Colore e forma: Light-Yellow Solid

Peso molecolare: 392.4

Ref: TM-T1703

SN-38

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Colore e forma: Light Yellow To Yellow

Peso molecolare: 392.40

Ref: TR-S589950

Irinotecan EP Impurity E

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Peso molecolare: 392.41

Ref: ST-EA-CP-I9005

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.

Formula: C₂₂H₂₀N₂O₅

Purezza: Min. 98 Area-%

Colore e forma: Off-White Yellow Powder

Peso molecolare: 392.4 g/mol

Ref: 3D-FE29579

7-Ethyl-10-hydroxy-camptothecin

CAS: 86639-52-3

Formula: C₂₂H₂₀N₂O₅

Purezza: 98%

Colore e forma: Yellow powder

Peso molecolare: 392.411

Ref: 10-F046379

SN-38-13C3

Prodotto controllato

CAS: 86639-52-3

Formula: C₃C₁₉H₂₀N₂O₅

Colore e forma: Neat

Peso molecolare: 395.383

Ref: TR-S589954

SN-38-d5

Prodotto controllato

CAS: 86639-52-3

Formula: C₂₂D₅H₁₅N₂O₅

Colore e forma: Neat

Peso molecolare: 397.435

Ref: TR-S589953