CAS 871543-07-6
:Formula:C16H23Cl2N3O2S
InChI:InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
InChI key:BFOPDSJOLUQULZ-GXKRWWSZSA-N
SMILES:C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C.Cl.Cl
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H-1152 dihydrochloride
CAS:H-1152 dihydrochlorideFormula:C16H23Cl2N3O2SPurezza:99.5%Peso molecolare:392.34H-1152 Dihydrochloride
CAS:Prodotto controllatoStability Hygroscopic
Applications ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
References Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002), Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002)Formula:C16H21N3O2S·2ClHColore e forma:NeatPeso molecolare:392.34H-1152 2HCl
CAS:(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochlorideFormula:C16H23Cl2N3O2SPurezza:99%Peso molecolare:392.34H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Formula:C16H23Cl2N3O2SPurezza:99.85%Colore e forma:White SolidPeso molecolare:392.34H-1152 (dihydrochloride)
CAS:Formula:C16H23Cl2N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:392.3437H 1152 dihydrochloride
CAS:Inhibitor of Rho-kinase
Formula:C16H23Cl2N3O2SPurezza:Min. 95%Peso molecolare:392.34 g/molRef: 3D-FD22031
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