CAS 87760-53-0

Tandospirone

Descrizione:

Tandospirone è un farmaco ansiolitico utilizzato principalmente nel trattamento dei disturbi d'ansia. Appartiene alla classe di farmaci noti come azapironi, caratterizzati dalla loro struttura chimica unica che include un sistema biciclico. La sostanza agisce come un agonista selettivo del recettore della serotonina, mirando in particolare al recettore 5-HT1A, che gioca un ruolo cruciale nella modulazione dell'umore e dell'ansia. Tandospirone è noto per il suo profilo di effetti collaterali relativamente basso rispetto alle benzodiazepine tradizionali, rendendolo un'opzione preferita per la gestione a lungo termine dell'ansia. Viene tipicamente somministrato per via orale e ha un inizio d'azione moderato. La farmacocinetica di Tandospirone indica che è ben assorbito, con una biodisponibilità che consente livelli terapeutici efficaci. Inoltre, ha un profilo di sicurezza favorevole, con un rischio minimo di dipendenza o sintomi di astinenza, il che rappresenta un vantaggio significativo rispetto ad altri ansiolitici. In generale, Tandospirone rappresenta un'opzione preziosa nella gestione farmacologica dei disturbi d'ansia.

Formula: C₂₁H₂₉N₅O₂

InChI: InChI=1/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-

InChI key: InChIKey=CEIJFEGBUDEYSX-FZDBZEDMNA-N

SMILES: O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1CCCCN4CCN(CC4)C=5N=CC=CN5)[H])[H]

Sinonimi:

• (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-bicyclo[2.2.1]heptanedicarboximide
• (1R,2S,6R,7S)-4-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5.2.1.0~2,6~]decane-3,5-dione
• (3aR,4S,7R,7aS)-2-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• (3aa,4b,7b,7aa)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aα,4β,7β,7aα)-
• 4,7-methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-
• rel-(3aR,4S,7R,7aS)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
• Tandospirone

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Peso molecolare: 383.49

Ref: 7W-GP5686

Tandospirone

CAS: 87760-53-0

Tandospirone

Formula: C₂₁H₂₉N₅O₂

Purezza: 99%

Peso molecolare: 383.49

Ref: 54-BUP12642

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 383.50

Ref: 4Z-T-212001

(3aα,4β,7β,7aα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 383.4873

Ref: IN-DA0036C9

Tandospirone

Prodotto controllato

CAS: 87760-53-0

Applications Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
References Seymour, P.A., et al.: Prog. Clin. Biol. Res., 361, 453 (1990), Evans, S.M., et al.: J. Pharmacol. Exp. Ther., 271, 683 (1994),

Formula: C₂₁H₂₉N₅O₂

Colore e forma: Neat

Peso molecolare: 383.49

Ref: TR-T006430

rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Purezza: 97%

Peso molecolare: 383.49

Ref: IN-DG152373

Tandospirone

CAS: 87760-53-0

Tandospirone (SM-3997) is a 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity used in the study of central nervous system disorders.

Formula: C₂₁H₂₉N₅O₂

Purezza: 99.24%

Colore e forma: Solid

Peso molecolare: 383.4873

Ref: TM-TQ0315

Tandospirone

CAS: 87760-53-0

Tandospirone is a psychotropic drug that acts as a selective serotonin receptor partial agonist. It is derived from a synthetic source, specifically targeting the 5-HT1A receptors in the brain. Tandospirone modulates serotonergic neurotransmission by binding to these receptors, which are associated with mood regulation. This action results in the anxiolytic and antidepressant effects observed with the drug.

Formula: C₂₁H₂₉N₅O₂

Purezza: Min. 95%

Peso molecolare: 383.49 g/mol

Ref: 3D-FT28000

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Peso molecolare: 383.5

Ref: BE-RMCT018000

TANDOSPIRONE

CAS: 87760-53-0

Purezza: 97%

Peso molecolare: 383.4960022

Ref: 10-F802602

Tandospirone hydrochloride

CAS: 87760-53-0

Tandospirone hydrochloride is a drug that affects the serotonin receptor 5-HT1A. It has been shown to have a number of clinical properties, including the treatment of anxiety, depression and irritable bowel syndrome. Tandospirone has been shown to be effective in combination with sodium carbonate for the treatment of high-resistant symptoms. This drug inhibits dopamine uptake and increases locomotor activity by blocking D2 receptors in the brain. Tandospirone also has pharmacological effects on 5-HT1 receptors, which are involved in regulating mood and sleep cycles.

Formula: C₂₁H₂₉N₅O₂·HCl

Purezza: Min. 95%

Peso molecolare: 419.95 g/mol

Ref: 3D-FT31558

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Peso molecolare: 383.5

Ref: ST-EA-CP-T119000