CAS 877810-03-2

Formula: C18H17N3O4

InChI: InChI=1S/C18H17N3O4/c1-23-11-4-3-5-13(8-11)25-16-10-20-18(19)21-17(16)14-7-6-12(24-2)9-15(14)22/h3-10,22H,1-2H3,(H2,19,20,21)

InChI key: PYBOOANVVNTMPL-UHFFFAOYSA-N

SMILES: COC1=CC(=CC=C1)OC2=CN=C(N=C2C3=C(C=C(C=C3)OC)O)N

APD-94

CAS: 877810-03-2

APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.

Formula: C₁₈H₁₇N₃O₄

Colore e forma: Solid

Peso molecolare: 339.3453

Ref: TM-T206828