CAS 88899-55-2

Bafilomicina A1

Descrizione:

Bafilomicina A1 è un antibiotico macrolide che è principalmente conosciuto per il suo ruolo come potente inibitore delle H+-ATPasi di tipo vacuolare (V-ATPasi), che sono essenziali per acidificare i compartimenti intracellulari nelle cellule eucariote. Questo composto è derivato dalla fermentazione del batterio Streptomyces griseus e presenta una struttura complessa caratterizzata da un grande anello di lattone e molteplici gruppi funzionali, contribuendo alla sua attività biologica. Bafilomicina A1 è spesso utilizzato nella ricerca per studiare processi cellulari come autofagia, endocitosi e funzione lisosomiale grazie alla sua capacità di interrompere i gradienti di protoni attraverso le membrane. Inoltre, è stato indagato per le sue potenziali applicazioni terapeutiche nel cancro e in altre malattie in cui è implicata l'attività della V-ATPasi. La sostanza è tipicamente maneggiata con cura in ambienti di laboratorio a causa della sua natura bioattiva e dei potenziali effetti citotossici. Le sue proprietà di solubilità e stabilità possono variare a seconda del solvente e delle condizioni ambientali, rendendo importante considerare questi fattori durante le applicazioni sperimentali.

Formula: C₃₅H₅₈O₉

InChI: InChI=1/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key: InChIKey=XDHNQDDQEHDUTM-JQWOJBOSSA-N

SMILES: [C@@H]([C@@H]([C@H](C)[C@@]1([C@@H](OC)/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(\C)/C=C(\OC)/C(=O)O1)[H])O)(C)[C@]2(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C2

Sinonimi:

• (-)-Bafilomycin A₁
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• Hygrolidin, 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-
• NSC 381866
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, [7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-
• Oxacyclohexadecane, hygrolidin deriv.
• alpha-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
• tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• alpha-D-threo-pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
• Bafilomycin A1
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5
• Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus
• Bafilomycin A1 from Streptomycesgriseus, 10 ug
• BAFILOMYCIN A1, STREPTOMYCES GRISEUS
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o
• BAFILOMYCIN A1, 98+%
• BafilomycinA1fromStreptomycesgriseus
• 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin
• BAFILOMYCIN A1 95%
• Bafilomycin A1(Baf-A1)

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1, 88899-55-2, is a specific inhibitor of vacuolar ATPases which exhibits antibacterial, antifungal, antineoplastic, and immunosuppressive properties. Learn more.

Formula: C₃₅H₅₈O₉

Colore e forma: White, Solid or film

Peso molecolare: 622.84

Ref: 02-J61835

Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

CAS: 88899-55-2

Bafilomycin A1, 88899-55-2, is a specific inhibitor of vacuolar ATPases which exhibits antibacterial, antifungal, antineoplastic, and immunosuppressive properties. Learn more.

Formula: C₃₅H₅₈O₉

Colore e forma: Liquid, Pale yellow

Peso molecolare: 622.84

Ref: 02-J67193

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

CAS: 88899-55-2

Formula: C₃₅H₅₈O₉

Purezza: %

Colore e forma: Solid

Peso molecolare: 622.8296

Ref: IN-DA0039AQ

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1

Purezza: ≥95%

Peso molecolare: 622.83g/mol

Ref: 54-BUP16335

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1

Formula: C₃₅H₅₈O₉

Purezza: By hplc: >95% (Typical Value in Batch COA)

Colore e forma: white lyophilizate solid

Peso molecolare: 622.83g/mol

Ref: 54-BIB0132

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.

Formula: C₃₅H₅₈O₉

Purezza: 95.87% - 99.36%

Colore e forma: Solid

Peso molecolare: 622.83

Ref: TM-T6740

Bafilomycin A1

CAS: 88899-55-2

Formula: C₃₅H₅₈O₉

Purezza: ≥ 97.0%

Colore e forma: White or off-white solid

Peso molecolare: 622.83

Ref: 7W-GA6363

Bafilomycin A1

Prodotto controllato

CAS: 88899-55-2

Stability Hygroscopic
Applications Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
References Bownman, E., et al.: PNAS, 85, 7972 (1988); Umata, T., et al.: J. Biol. Chem., 265, 21940 (1990); Saurin, A., et al.: Biochem.

Formula: C₃₅H₅₈O₉

Colore e forma: Neat

Peso molecolare: 622.83

Ref: TR-B110000

Bafilomycin A1

CAS: 88899-55-2

Inhibitor of vacuolar-type proton pump

Formula: C₃₅H₅₈O₉

Purezza: Min. 95 Area-%

Colore e forma: White Powder

Peso molecolare: 622.83 g/mol

Ref: 3D-FB146475