CAS 925902-48-3

Formula: C20H21FO4

InChI: InChI=1S/C20H21FO4/c1-13(2)12-24-20(23)25-19(22)14(3)16-9-10-17(18(21)11-16)15-7-5-4-6-8-15/h4-11,13-14H,12H2,1-3H3/t14-/m0/s1

InChI key: WAYFJZACBWHVSA-AWEZNQCLSA-N

SMILES: C[C@@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OC(=O)OCC(C)C

(S)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic (Isobutyl Carbonic) Anhydride

Prodotto controllato

CAS: 925902-48-3

Applications (S)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic (Isobutyl Carbonic) Anhydride is an intermediate in the synthesis of Rimacalib (R505015), an inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib.
References Westra, Johanna., et al.: BMC Musculoskelet Disord.,11 , No pp. given. (2010);

Formula: C₂₀H₂₁FO₄

Colore e forma: Neat

Peso molecolare: 344.377

Ref: TR-F925905