CAS 951385-68-5

Formula: C22H30N6O4S

InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)/i10D2,11D2,12D2,13D2

InChI key: BNRNXUUZRGQAQC-BGKXKQMNSA-N

SMILES: [2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])S(=O)(=O)C2=CC(=C(C=C2)OCC)C3=NC4=C(C(=O)N3)N(N=C4CCC)C)([2H])[2H])[2H]

Sildenafil-d8

CAS: 951385-68-5

Formula: C₂₂H₂₂D₈N₆O₄S

Colore e forma: White To Off-White Solid

Peso molecolare: 482.63

Ref: 4Z-S-063

Sildenafil-d8 (piperazine-d8)

CAS: 139755-83-2, 951385-68-5

Purezza: 99 atom % D

Colore e forma: White Solid

Peso molecolare: 482.63

Ref: 3U-D7300

Sildenafil-D8

CAS: 951385-68-5

Sildenafil-D8 is a deuterium-labeled form of Sildenafil (T1164) that can be used for isotope tracing. Sildenafil is a selective phosphodiesterase 5 (PDE5) inhibitor that promotes smooth muscle relaxation by inhibiting the degradation of cyclic guanosine monophosphate (cGMP). Sildenafil-D8 can be used for isotope labeling and pharmacological studies of sildenafil.

Formula: C₂₂H₂₂D₈N₆O₄S

Colore e forma: Solid

Peso molecolare: 482.63

Ref: TM-TMID-0043

Sildenafil-[d8]

CAS: 951385-68-5

Formula: C₂₂H₃₀N₆O₄S

Peso molecolare: 482.6

Ref: BE-MD-7450

Sildenafil-d8

CAS: 951385-68-5

Formula: C₂₂H₃₀N₆O₄S

Peso molecolare: 482.6

Ref: BE-RMCS096126

Sildenafil-d8

Prodotto controllato

CAS: 951385-68-5

Applications Sildenafil-d8 is the labeled analogue of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998)

Formula: C₂₂D₈H₂₂N₆O₄S

Colore e forma: Neat

Peso molecolare: 482.63

Ref: TR-S435003

Sildenafil-d8

Prodotto controllato

CAS: 951385-68-5

Sildenafil-d8 is a chemical that is used in medicine. It is the 8-deuterated analog of sildenafil. Sildenafil-d8 has been shown to be more potent than sildenafil in inhibiting phosphodiesterase type-5 (PDE5) and to have a longer half-life. This drug has been shown to be effective in the treatment of pulmonary hypertension, which may be due to its ability to relax smooth muscle cells. Sildenafil-d8 can also be used for the treatment of erectile dysfunction, as it inhibits PDE5, an enzyme that degrades cyclic guanosine monophosphate (cGMP). The effects of this drug are dose dependent and are enhanced by the presence of a matrix effect. This drug is extracted from methanol using liquid chromatography with UV detection at 254 nm and mass spectrometry detection at m/z=

Formula: C₂₂H₂₂D₈N₆O₄S

Purezza: Min. 95%

Peso molecolare: 482.63 g/mol

Ref: 3D-BNB38568