CymitQuimica logo

CAS 951792-83-9

:

L-Valina, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-dietil-3,4,12,14-tetraidro-4-idrossi-3,14-diosso-1H-pirano[3′,4′:6,7]indolizino[1,2-b]chinolin-9-il]ossi]carbonil]cicloesil]metil]amino]carbonil]cicloesil]metil]-2,5-diosso-3-pirrolidinil]-L-cisteinil-L-valil-L-lisil-L-arginil-glicil-L-leucil-L-lisil-L-leucil-L-arginil-L-istidil-L-valil-L-arginil-L-prolil-L-arginil-L-valil-L-treonil-L-arginil-L-metionil-L-α-aspartil-

Descrizione:
La sostanza chimica nota come L-Valina, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-dietil-3,4,12,14-tetraidro-4-idrossi-3,14-diosso-1H-pirano[3′,4′:6,7]indolizino[1,2-b]chinolin-9-il]ossi]carbonil]cicloesil]metil]amino]carbonil]cicloesil]metil]-2,5-diosso-3-pirrolidinil]-L-cisteinil-L-valil-L-lisil-L-arginil-glicil-L-leucil-L-lisil-L-leucil-L-arginil-L-istidil-L-valil-L-arginil-L-prolil-L-arginil-L-valil-L-treonil-L-arginil-L-metionil-L-α-aspartil- è un peptide complesso con una lunga catena di amminoacidi, tra cui L-valina, L-cisteina, L-lisina e L-arginina, tra gli altri. Questo composto presenta più gruppi funzionali, tra cui gruppi amminici, acidi carbossilici e idrossili, che contribuiscono alla sua potenziale attività biologica. La sua struttura intricata suggerisce che potrebbe avere interazioni specifiche con bersagli biologici, influenzando possibilmente la sintesi proteica o le vie di segnalazione cellulare. La presenza di strutture cicliche e vari stereocentri indica che potrebbe presentare proprietà chirali, che possono influenzare la sua farmacocinetica e farmacodinamica. In generale, questa sostanza è probabilmente di interesse nella chimica medicinale e nella biochimica per le sue potenziali applicazioni terapeutiche.
Formula:C145H233N43O33S2
InChI:InChI=1S/C145H233N43O33S2/c1-17-85-86-60-84(45-46-91(86)169-115-87(85)68-187-105(115)61-89-88(134(187)212)69-220-139(218)145(89,219)18-2)221-138(217)82-43-37-79(38-44-82)64-165-116(194)81-41-39-80(40-42-81)67-188-108(191)63-106(136(188)214)223-70-90(148)117(195)181-110(74(7)8)130(208)175-94(30-20-22-49-147)119(197)170-92(31-23-50-160-140(149)150)118(196)166-66-107(190)168-100(57-72(3)4)125(203)171-93(29-19-21-48-146)121(199)178-101(58-73(5)6)126(204)172-95(32-24-51-161-141(151)152)122(200)179-102(59-83-65-159-71-167-83)127(205)183-111(75(9)10)131(209)177-99(35-27-54-164-144(157)158)135(213)186-55-28-36-104(186)129(207)174-97(34-26-53-163-143(155)156)124(202)182-112(76(11)12)132(210)185-114(78(15)189)133(211)176-96(33-25-52-162-142(153)154)120(198)173-98(47-56-222-16)123(201)180-103(62-109(192)193)128(206)184-113(77(13)14)137(215)216/h45-46,60-61,65,71-82,90,92-104,106,110-114,189,219H,17-44,47-59,62-64,66-70,146-148H2,1-16H3,(H,159,167)(H,165,194)(H,166,196)(H,168,190)(H,170,197)(H,171,203)(H,172,204)(H,173,198)(H,174,207)(H,175,208)(H,176,211)(H,177,209)(H,178,199)(H,179,200)(H,180,201)(H,181,195)(H,182,202)(H,183,205)(H,184,206)(H,185,210)(H,192,193)(H,215,216)(H4,149,150,160)(H4,151,152,161)(H4,153,154,162)(H4,155,156,163)(H4,157,158,164)/t78-,79?,80?,81?,82?,90+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,106?,110+,111+,112+,113+,114+,145+/m1/s1
InChI key:FWGGCDGFVSQQOB-LMKVGCSMSA-N
SMILES:CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)C6CCC(CC6)CNC(=O)C7CCC(CC7)CN8C(=O)CC(C8=O)SC[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC9=CN=CN9)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)O)N
Sinonimi:
  • L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lys...
  • L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lysyl-L-leucyl-L-arginyl-L-histidyl-L-valyl-L-arginyl-L-prolyl-L-arginyl-L-valyl-L-threonyl-L-arginyl-L-methionyl-L-α-aspartyl-
Trovati 1 prodotti.
  • DTS-108
    Targetmol
    + Info

    DTS-108

    CAS:
    DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.
    Formula:C145H233N43O33S2
    Colore e forma:Solid
    Peso molecolare:3170.8

    Ref: TM-T203287

    10mg
    Prezzo su richiesta
    50mg
    Prezzo su richiesta