CAS 951950-33-7

Formula: C17H18N4O6

InChI: InChI=1S/C17H18N4O6/c22-14(19-8-16(24)25)7-18-15(23)9-27-10-3-4-12-11(6-10)17(26)21-5-1-2-13(21)20-12/h3-4,6H,1-2,5,7-9H2,(H,18,23)(H,19,22)(H,24,25)

InChI key: BGFQHCHLBHLYBO-UHFFFAOYSA-N

SMILES: C1CC2=NC3=C(C=C(C=C3)OCC(=O)NCC(=O)NCC(=O)O)C(=O)N2C1

Pevonedistat

CAS: 951950-33-7

Pevonedistat is a novel investigational drug that inhibits the neddylation of proteins. It blocks the enzymatic activity of protein neddylation (protein O-glucosyltransferase) and prevents the addition of a sugar molecule to lysine residues in proteins. Pevonedistat has been shown to be an inhibitor against the mcl-1 protein, which is an important regulator of apoptosis. Pevonedistat also targets energy metabolism pathways and signal transduction pathways, and its pharmacological effects are thought to be due to its ability to inhibit these processes.

Formula: C₁₇H₁₈N₄O₆

Purezza: Min. 95%

Peso molecolare: 374.35 g/mol

Ref: 3D-BP172950

NAE-IN-3

CAS: 951950-33-7

NAE-IN-3 (compound 1) is a potent and highly selective non-covalent competitive inhibitor of NEDD8-activating enzyme (NAE) with an IC₅₀ of 0.8 μM. It inhibits NAE by blocking the ATP binding site and demonstrates selectivity over related E1 enzymes UAE and SAE. NAE-IN-3 is applicable for cancer research.

Formula: C₁₇H₁₈N₄O₆

Peso molecolare: 374.35

Ref: TM-T214226