CAS 968-81-0

Acetoesamide

Descrizione:

Acetoesamide è un composto chimico classificato come sulfonilurea, utilizzato principalmente nella gestione del diabete mellito di tipo 2. Funziona come un agente ipoglicemizzante orale, stimolando il rilascio di insulina dal pancreas e migliorando la sensibilità all'insulina nei tessuti periferici. La struttura molecolare di Acetoesamide include una catena di esametilene e un gruppo acetamide, contribuendo alle sue proprietà farmacologiche. Viene tipicamente somministrato in forma di compresse ed è noto per la sua moderata efficacia nella riduzione dei livelli di glucosio nel sangue. Acetoesamide ha una solubilità relativamente bassa in acqua, il che può influenzare la sua assorbimento e biodisponibilità. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, ipoglicemia e reazioni allergiche. Come con altre sulfoniluree, il suo utilizzo richiede un attento monitoraggio dei livelli di glucosio nel sangue per evitare potenziali complicazioni. Il composto viene metabolizzato nel fegato e la sua farmacocinetica può essere influenzata da fattori come età, funzione epatica e farmaci concomitanti. In generale, Acetoesamide gioca un ruolo nella gestione del diabete, sebbene sia stato in gran parte sostituito da nuovi agenti con profili di sicurezza ed efficacia migliorati.

Formula: C₁₅H₂₀N₂O₄S

InChI: InChI=1/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChI key: InChIKey=VGZSUPCWNCWDAN-UHFFFAOYSA-N

SMILES: S(NC(NC1CCCCC1)=O)(=O)(=O)C2=CC=C(C(C)=O)C=C2

Sinonimi:

• 1-(4-Acetylbenzenesulfonyl)-3-Cyclohexylurea
• 1-(4-Acetylphenyl)sulfonyl-3-cyclohexylurea
• 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea
• 1-[(p-Acetylphenyl)sulfonyl]-3-cyclohexylurea
• 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide
• 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
• Acetohexamid
• Acetohexamida
• Benzenesulfonamide, 4-acetyl-N-[(cyclohexylamino)carbonyl]-
• Dimelin
• Dimelin (antidiabetic)
• Dimelor
• Dymelor
• Gamadiabet
• Hypoglicil
• Metaglucina
• Minoral
• N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea
• Ordimel
• Tsiklamid
• U 14812
• Urea, 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexyl-
• Acetohexamide
• DyMelor-d6
• -d6 DiMelin-d6
• Hypoglicil-d6
• 4-Acetyl-N-[(cyclohexyl-d6-aMino)carbonyl]benzenesulfonaMide
• Acetohexamide (250 mg)
• AcetohexaMide-d6
• Cyclamide
• 1-(4-acetylphenyl)sulfonyl-3-cyclohexyl-urea
• 1-cyclohexyl-3-(4-ethanoylphenyl)sulfonyl-urea
• gamadiaber
• 1-[(p-Acetylphenyl)su
• 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-ure
• GaMadiabet-d6
• 4-acetyl-n-[(cyclohexylamino)carbonyl]-benzenesulfonamid
• nci-c03247
• U 14812-d6
• 4-acetyl-n-benzenesulfonamide
• 1-(p-acetylbenzenesulfonyl)-3-cyclohexylure
• 1-(p-Acetylbenzenesulfonyl)
• OrdiMel-d6
• 4-acetyl-n-((cyclohexylamino)carbonyl)-benzenesulfonamid
• ACETOHEXAMIDE, USP GRADE ORAL HYPOGLYCEM IC AGE
• Metaglucina-d6
• u14812
• TsiklaMid-d6
• Minoral-d6

Acetohexamide

CAS: 968-81-0

Acetohexamide

Formula: C₁₅H₂₀N₂O₄S

Purezza: ≥98%

Peso molecolare: 324.4

Ref: 54-BUP14643

Acetohexamide

CAS: 968-81-0

Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.

Formula: C₁₅H₂₀N₂O₄S

Purezza: 99.01% - 99.19%

Colore e forma: White Solid

Peso molecolare: 324.395

Ref: TM-T0816

Acetohexamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Peso molecolare: 324.40

Ref: 7W-GL0522

4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 324.3953

Ref: IN-DA005SIZ

Acetohexamide (Standard)

CAS: 968-81-0

Acetohexamide (Standard) is the standard substance of Acetohexamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.

Formula: C₁₅H₂₀N₂O₄S

Peso molecolare: 324.395

Ref: TM-TMSM-0357

Acetohexamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Colore e forma: White To Light Red

Peso molecolare: 324.4

Ref: 61-FOR1726.00

Acetohexamide

Prodotto controllato

CAS: 968-81-0

Applications Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);

Formula: C₁₅H₂₀N₂O₄S

Colore e forma: Neat

Peso molecolare: 324.4

Ref: TR-A162650

Acetohexamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Colore e forma: Solid

Peso molecolare: 324.4

Ref: BE-BePure-20056

Acetohexamide

CAS: 968-81-0

Acetohexamide

Formula: C₁₅H₂₀N₂O₄S

Purezza: 99%

Peso molecolare: 324.4

Ref: IN-DG16071

Acetohexamide

CAS: 968-81-0

Purezza: 98%

Peso molecolare: 324.4

Ref: 10-F980328

Acetohexamide

CAS: 968-81-0

Acetohexamide is a hypoglycemic drug that binds to the sulfonylurea receptor on pancreatic beta-cells and stimulates insulin release. It has been shown to have an oral hypoglycemic effect in humans, as well as in rats. Acetohexamide has been shown to inhibit the action of nonsteroidal anti-inflammatory drugs, such as indomethacin, through competitive inhibition. Acetohexamide also inhibits the enzyme activity of estradiol benzoate and acetohexamide hydrolase. This drug is not active against bacteria or fungi, but has been shown to be effective against some viruses. Acetohexamide is absorbed by the gastrointestinal tract and excreted unchanged in urine and feces. The drug does not bind to proteins and does not cross the blood-brain barrier.

Formula: C₁₅H₂₀N₂O₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 324.4 g/mol

Ref: 3D-FA16951