CAS 98603-84-0

Sialil-Lewis X

Descrizione:

Sialil-Lewis X, noto anche come Lewis X sialilato, è una struttura carboidratica che gioca un ruolo significativo nei processi di adesione e riconoscimento cellulare, in particolare nel contesto delle risposte immunitarie e della metastasi del cancro. È un glicano, specificamente un oligosaccaride fucosilato sialilato, il che significa che contiene residui di acido sialico e fucosio. Questo composto si trova spesso sulla superficie di glicoproteine e glicolipidi, contribuendo alla formazione di ligandi di selectina che mediano il traffico dei leucociti e l'infiammazione. La presenza di acido sialico conferisce una carica negativa, influenzando le sue interazioni con proteine e altre biomolecole. Sialil-Lewis X è anche di interesse nella ricerca biomedica e nelle applicazioni terapeutiche, poiché può essere coinvolto nella modulazione delle risposte immunitarie e ha potenziali implicazioni nei sistemi di somministrazione di farmaci mirati. La sua complessità strutturale e la sua importanza biologica lo rendono un argomento di studio nella glicobiologia e nei campi correlati.

Formula: C₃₁H₅₂N₂O₂₃

InChI: InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

InChI key: InChIKey=LAQPKDLYOBZWBT-NYLDSJSYSA-N

SMILES: O([C@@]1(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C1)[H])[C@@H]2[C@@H](O)[C@H](O[C@@H]([C@H](O[C@H]3[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O3)[C@@H](NC(C)=O)C=O)[C@@H](CO)O)O[C@H](CO)[C@@H]2O

Sinonimi:

• 3′-Sialyl-Lewis X
• 5-(acetylamino)-3,5-dideoxy-D-erythro-non-2-ulopyranonosyl-(2->3)hexopyranosyl-(1->4)-[6-deoxyhexopyranosyl-(1->3)]-2-(acetylamino)-2-deoxyhexopyranose
• 5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-[6-deoxy-alpha-L-galactopyranosyl-(1->3)]-2-(acetylamino)-2-deoxy-D-glucose
• <span class="text-smallcaps">D</smallcap>-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</span>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-
• O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</smallcap>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-<smallcap>D</span>-glucose
• SLe^x
• Sialyl Le^x tri
• Sialyl Lewis X
• Ssea 1
• SLex
• D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-

(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydrox

CAS: 98603-84-0

(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydrox

Formula: C₃₁H₅₂N₂O₂₃

Purezza: 98%

Peso molecolare: 820.75

Ref: 54-OR1067114

Sialyl-Lewis X

CAS: 98603-84-0

(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid

Formula: C₃₁H₅₂N₂O₂₃

Purezza: 98%

Peso molecolare: 820.74

Ref: IN-DG01096963

Sialyl-Lewis X

CAS: 98603-84-0

Formula: C₃₁H₅₂N₂O₂₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 820.7442

Ref: IN-DA01E70Y

Sialyl-Lewis X

CAS: 98603-84-0

sLeX: sialylated, fucosylated tetrasaccharide, ligand for selectins, inhibits neutrophil recruitment.

Formula: C₃₁H₅₂N₂O₂₃

Colore e forma: Solid

Peso molecolare: 820.748

Ref: TM-T35884

3′-Sialyl-Lewis-X tetrasaccharide

CAS: 98603-84-0

Formula: C₃₁H₅₁N₂NaO₂₃

Purezza: ≥ 85%

Colore e forma: White to pale brown solid

Peso molecolare: 842.73

Ref: 7W-GC9537

3'-Sialyl Lewis X, sodium salt

CAS: 98603-84-0

Sialyl Lewis X (SLeX) is a carbohydrate antigen, related to cell adhesion and it has been shown that inhibition of SLeX synthesis leads to decreased adhesion of trophoblast cells to endometrial epithelial cells (Collins, 2006). Sialyl Lewis X is displayed on the terminus of glycolipids that are present on the surface of white blood cells and it has been shown that SLeX has an important role in inflamation processes. The inital adhesion of white blood cells to a site of injury is mediated by E-selectins which are specific for SLeX. Cell-cell recognition between leukocytes and endothelial cells in blood is believed to occur in part through interactions between lectins and oligosaccharide ligands. SLeX is frequently expressed in human cancer cells and primary tumors. It has been demonstrated that SLeX was involved in the adhesion of tumor cells to vascular endothelium. The potential role of SLeX in the tumor metastatic process has been supported by several clinical studies (Liang, 2016).

Formula: C₃₁H₅₁N₂NaO₂₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 842.73 g/mol

Ref: 3D-OS04058

3'-Sialyl Lewis X

CAS: 98603-84-0

Please enquire for more information about 3'-Sialyl Lewis X including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₃₁H₅₂N₂O₂₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 820.75 g/mol

Ref: 3D-OS183415

Sialyl Lewis X

Prodotto controllato

CAS: 98603-84-0

Applications Antigen which binds to endothelial adhesion molecule, E-selectin.
References Fukushima, K., et al.: Cancer Research, 44, 5279 (1984), Zein, N., et al.: Science, 240, 1198 (1988), Phillips, M.L., et al.: Science, 250, 1130 (1990), Walz, G., et al.: P.N.A.S. U.S.A., 88, 6224 (1991), Walker, S., et al.: P.N.A.S. U.S.A., 89, 4608 (1992)

Formula: C₃₁H₅₂N₂O₂₃

Colore e forma: Neat

Peso molecolare: 820.74

Ref: TR-S410000