CAS 992-21-2

Limeciclina

Descrizione:

Limeciclina è un antibiotico semisintetico appartenente alla classe delle tetracicline, utilizzato principalmente per trattare varie infezioni batteriche. Mostra un'attività antibatterica ad ampio spettro contro batteri Gram-positivi e Gram-negativi inibendo la sintesi proteica attraverso il legame con la subunità ribosomiale 30S. Questa azione previene la crescita e la riproduzione dei batteri. Limeciclina è caratterizzato dalla sua stabilità in ambienti acidi, il che ne migliora la biodisponibilità quando somministrato per via orale. È spesso prescritto per condizioni come acne, infezioni delle vie respiratorie e alcune infezioni cutanee. Il composto è generalmente ben tollerato, anche se può causare effetti collaterali come disturbi gastrointestinali, fotosensibilità e potenziali effetti sullo sviluppo delle ossa e dei denti nei bambini. Come altre tetracicline, è controindicato in donne in gravidanza e bambini piccoli a causa del rischio di scolorimento dei denti e effetti scheletrici.

Formula: C₂₉H₃₈N₄O₁₀

InChI: InChI=1/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-16(27(40)41)8-4-5-10-30/h6-7,9,14-16,21,31-32,34-35,39,42-43H,4-5,8,10-12,30H2,1-3H3,(H,40,41)/b26-20+/t14?,15-,16?,21-,28+,29-/m0/s1

InChI key: InChIKey=AHEVKYYGXVEWNO-UEPZRUIBSA-N

SMILES: O[C@@]12[C@@](C[C@]3(C(=C1O)C(=O)C=4C([C@@]3(C)O)=CC=CC4O)[H])([C@H](N(C)C)C(O)=C(C(NCNCCCC[C@@H](C(O)=O)N)=O)C2=O)[H]

Sinonimi:

• (+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, lysinemethylene deriv.
• <span class="text-smallcaps">L</span>-Lysine, N⁶-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
• <span class="text-smallcaps">L</span>-Lysine, N⁶-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
• Armyl
• Ciclisin
• Ciclolysal
• Ciclolysine
• Infaciclina
• L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
• Limeciclina
• Lisinbiotic
• Lisinciclina
• Lymecyclin
• Lymecycline
• Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
• Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
• Lysine, N⁶-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
• Lysine, N⁶-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, <span class="text-smallcaps">L</span>-
• Mucomycin
• N-Lysinomethyltetracycline
• N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
• N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
• N6-[[[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-oxtahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
• N²-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
• N⁶-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
• N⁶-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-<span class="text-smallcaps">L</span>-lysine
• Tertamyl
• Tetracycline-<span class="text-smallcaps">L</span>-methylenelysine
• Tetracycline-L-methylenelysine
• Tetracyclinemethylenelysine
• Tetralisal
• Tetralysal
• Tetramyl
• Vebicyclysal
• L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
• N~2~-({[(Z)-[(4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
• (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• N~2~-({[(E)-[(4S,4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
• N-(N2-lysinomethyl)tetracycline
• N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
• lymecycline USP/EP/BP
• Lymecycline (85%)
• N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine
• Tetracyclinemethylene lysine

Lymecycline

CAS: 992-21-2

Lymecycline

Formula: C₂₂H₂₃ClN₂O₈

Colore e forma: Dark Yellow

Peso molecolare: 478.8796

Ref: 47-218

Lymecycline

CAS: 992-21-2

Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.

Formula: C₂₉H₃₈N₄O₁₀

Colore e forma: Solid

Peso molecolare: 602.64

Ref: TM-T20164

Lymecycline

CAS: 992-21-2

Formula: C₂₉H₃₈N₄O₁₀

Peso molecolare: 602.64

Ref: 4Z-L-237001

Lymecycline-d8 (>80%)

Prodotto controllato

CAS: 992-21-2

Stability Light Sensitive, Temperature Sensitive
Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Formula: C₂₉H₃₀D₈N₄O₁₀

Purezza: >80%

Colore e forma: Neat

Peso molecolare: 610.68

Ref: TR-L487802

Lymecycline (85%)

CAS: 992-21-2

Stability Temperature sensitive
Applications A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Formula: C₂₉H₃₈N₄O₁₀

Purezza: 85%

Colore e forma: Yellow To Dark Brown

Peso molecolare: 602.63

Ref: TR-L487800

Lymecycline

CAS: 992-21-2

Lymecycline is a tetracycline antibiotic that has been shown to be effective in the treatment of inflammatory bowel disease, chronic arthritis, and experimental models of inflammatory reactions. Lymecycline inhibits epidermal growth factor (EGF) and its receptor EGF-R. This inhibition leads to reduced inflammation in the bowel. Lymecycline also has an anti-inflammatory effect on the skin, inhibiting reactive oxygen species (ROS) production from neutrophils and macrophages. It also reduces the symptoms of toxic epidermal necrolysis by preventing ROS production and reducing cytokines such as TNF-α and IL-1β. Lymecycline binds to magnesium ions, which are necessary for bacterial growth and replication. This binding leads to bacteriostatic activity against bacteria that are sensitive to lymecycline, including Mycobacterium tuberculosis and other infectious diseases. The histological

Formula: C₂₉H₃₈N₄O₁₀

Purezza: Min. 85 Area-%

Colore e forma: Powder

Peso molecolare: 602.63 g/mol

Ref: 3D-FL164019

Lymecycline

CAS: 992-21-2

Formula: C₂₉H₃₈N₄O₁₀

Peso molecolare: 602.64

Ref: 4Z-T-405

Lymecycline-d8

CAS: 992-21-2

Formula: C₂₉H₃₀D₈N₄O₁₀

Peso molecolare: 610.69

Ref: 4Z-T-406