EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 595 prodotti di "EGFR"
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Methyl 2,5-Dihydroxycinnamate
CAS:Formula:C10H10O4Purezza:>96.0%(HPLC)Colore e forma:White to Yellow powder to crystalPeso molecolare:194.19Curcumin (Natural)
CAS:Formula:C21H20O6Colore e forma:Light yellow to Brown powder to crystalPeso molecolare:368.39Tyrphostin A1
CAS:Formula:C11H8N2OPurezza:>98.0%(GC)Colore e forma:Light orange to Yellow to Green powder to crystalPeso molecolare:184.20Curcumin (Synthetic)
CAS:Formula:C21H20O6Purezza:>97.0%(T)Colore e forma:Light yellow to Brown powder to crystalPeso molecolare:368.39Tyrphostin AG 835
CAS:Formula:C18H16N2O3Purezza:>98.0%(HPLC)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:308.34Pelitinib
CAS:Formula:C24H23ClFN5O2Purezza:>97.0%(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:467.93Erlotinib Hydrochloride
CAS:Formula:C22H23N3O4·HClPurezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:429.90Gefitinib
CAS:Formula:C22H24ClFN4O3Purezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:446.91Lapatinib
CAS:Formula:C29H26ClFN4O4SPurezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:581.06Genistein
CAS:Formula:C15H10O5Purezza:>98.0%(HPLC)Colore e forma:White to Light yellow to Light orange powder to crystalPeso molecolare:270.24PD 153035 Hydrochloride
CAS:Formula:C16H14BrN3O2·HClPurezza:>97.0%(HPLC)Colore e forma:White to Light yellow to Light orange powder to crystalPeso molecolare:396.67Tyrphostin AG 490
CAS:Formula:C17H14N2O3Purezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:294.31Tyrphostin AG528
CAS:Formula:C18H14N2O3Purezza:>97.0%(HPLC)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:306.32Tyrphostin A23
CAS:Formula:C10H6N2O2Purezza:>98.0%(GC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:186.17Butein
CAS:Formula:C15H12O5Purezza:>98.0%(HPLC)Colore e forma:Light yellow to Brown powder to crystalPeso molecolare:272.26Tyrphostin AG 494
CAS:Formula:C16H12N2O3Purezza:>98.0%(HPLC)(N)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:280.28BLU-945
CAS:<p>BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.</p>Formula:C28H37FN6O3SPurezza:99.11% - 99.16%Colore e forma:SolidPeso molecolare:556.74-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
CAS:Formula:C16H14ClN3O2Purezza:99%Colore e forma:SolidPeso molecolare:315.7543Margetuximab
CAS:Margetuximab (MGAH-22) is a second generation anti-HER2 monoclonal antibody with anti-tumor activity.Purezza:95.3% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.3% (SDS-PAGE); 99.3% (SEC-HPLC)Colore e forma:LiquidMutated EGFR-IN-1
CAS:Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormula:C25H31N7OPurezza:98.91%Colore e forma:SolidPeso molecolare:445.56Panitumumab
CAS:<p>Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).</p>Purezza:95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:147 kDaErlotinib hydrochloride
CAS:<p>Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formula:C22H23N3O4·HClPurezza:99.78% - 99.85%Colore e forma:White Or Off-White PowderPeso molecolare:429.9(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
CAS:Formula:C17H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:294.3047Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purezza:99.12%Colore e forma:White-Yellowish To Yellow Powder Solid PowderPeso molecolare:390.51LCH-7749944
CAS:<p>LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.</p>Formula:C20H22N4O2Purezza:99.48%Colore e forma:SolidPeso molecolare:350.41Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Purezza:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidKhellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formula:C14H12O5Purezza:99.89% - 99.95%Colore e forma:Light Yellow CrystallinePeso molecolare:260.24Losatuxizumab
CAS:Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Purezza:97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Colore e forma:LiquidMethyl 2,5-Dihydroxycinnamate
CAS:Formula:C10H10O4Purezza:95%Colore e forma:SolidPeso molecolare:194.18404H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:Formula:C15H10O5Purezza:97%Colore e forma:SolidPeso molecolare:270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgPrezzo su richiesta100g114,00€10kgPrezzo su richiesta250g181,00€500g320,00€100mg26,00€AZ7550 hydrochloride
CAS:<p>AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H32ClN7O2Purezza:99.65%Colore e forma:SolidPeso molecolare:522.04Epertinib hydrochloride
CAS:<p>Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.</p>Formula:C30H28Cl2FN5O3Purezza:99.14%Colore e forma:SolidPeso molecolare:596.48Intetumumab
CAS:Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Purezza:97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.6 (kDa)O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purezza:97.17%Colore e forma:SolidPeso molecolare:432.881-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole
CAS:Formula:C25H23F3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:468.4709Petosemtamab
CAS:<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:145.97 kDaGefitinib
CAS:Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formula:C22H24ClFN4O3Purezza:99.92% - >99.99%Colore e forma:Light-Yellow Crystalline PowderPeso molecolare:446.92H-1-Benzopyran-2-one, 7,8-dihydroxy-
CAS:Formula:C9H6O4Purezza:95%Colore e forma:SolidPeso molecolare:178.1415N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
CAS:Formula:C22H24ClFN4O3Purezza:98%Colore e forma:SolidPeso molecolare:446.9024Pyrotinib dimaleate
CAS:<p>Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.</p>Formula:C40H39ClN6O11Purezza:97.27% - 99.52%Colore e forma:SolidPeso molecolare:815.22Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4Purezza:98.19% - 99.98%Colore e forma:White To Off-White PowderPeso molecolare:393.44(2E)-N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS:Formula:C30H29ClN6O3Purezza:98%Colore e forma:SolidPeso molecolare:557.0427Rilzabrutinib
CAS:<p>Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).</p>Formula:C36H40FN9O3Purezza:98.28% - 99.76%Colore e forma:SolidPeso molecolare:665.762-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
CAS:Formula:C18H13BrN4OPurezza:97%Colore e forma:SolidPeso molecolare:381.2260Ref: IN-DA00ABJJ
2mg51,00€5mg79,00€10mg119,00€25mg186,00€50mg225,00€100mg506,00€500mgPrezzo su richiestaRociletinib
CAS:<p>Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic</p>Formula:C27H28F3N7O3Purezza:98.52% - 99.25%Colore e forma:SolidPeso molecolare:555.55Lapatinib Ditosylate
CAS:<p>Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).</p>Formula:C29H26ClFN4O4S·2C7H8O3SPurezza:99.41%Colore e forma:Yellow SolidPeso molecolare:925.46Propanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS:Formula:C11H8N2OPurezza:98%Colore e forma:SolidPeso molecolare:184.1940N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine
CAS:Formula:C29H26ClFN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:581.0575Ref: IN-DA0039KT
1g106,00€5g222,00€50g573,00€100gPrezzo su richiesta250gPrezzo su richiesta25mg29,00€100mg44,00€250mg56,00€Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formula:C24H18ClFN4O2Purezza:99.89% - 99.91%Colore e forma:SolidPeso molecolare:448.88Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurezza:99.00% - 99.81%Colore e forma:PowderPeso molecolare:581.064-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)
CAS:Formula:C22H23ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:429.8967(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]-2-propenamide
CAS:Formula:C18H16N2O3Purezza:97%Colore e forma:SolidPeso molecolare:308.3312Lapatinib ditosylate monohydrate
CAS:<p>Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.</p>Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurezza:98% - 99.41%Colore e forma:Colourless To Light-Yellow CrystalPeso molecolare:943.47(2E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide
CAS:Formula:C18H24N2OSPurezza:95%Colore e forma:SolidPeso molecolare:316.4610AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formula:C41H44ClFN6O7S2Purezza:99.85% - 99.92%Colore e forma:SolidPeso molecolare:851.41Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Purezza:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Colore e forma:LiquidPD-149163 hydrochloride
PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.Formula:C42H72ClN9O6Colore e forma:SolidPeso molecolare:834.53Befotertinib
CAS:Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Formula:C29H32F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:567.61Laprituximab
CAS:Laprituximab (J2898A) is a humanized anti-EGFR antibody used for synthesizing ADC compound Laprituximab emtansine.Purezza:>95%Colore e forma:LiquidSJF 1521
CAS:<p>SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.</p>Formula:C57H61ClFN7O9SPurezza:99.20%Colore e forma:SolidPeso molecolare:1074.65OK2
OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.Formula:C42H62N14O9Purezza:98%Colore e forma:SolidPeso molecolare:907.03BMS-599626
CAS:BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Formula:C27H27FN8O3Purezza:98.73%Colore e forma:SolidPeso molecolare:530.55CH7233163
<p>CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.</p>Purezza:98%Colore e forma:SolidCaxmotabart
<p>Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.</p>Colore e forma:Odour LiquidARRY-380 (analog )
CAS:ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Formula:C29H27N7O4SPurezza:99.82%Colore e forma:SolidPeso molecolare:569.63Calotatug
Calotatug is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidEP26
EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.Formula:C42H42ClFN4O5Peso molecolare:736.28278Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Colore e forma:Odour LiquidSelf-assembling peptide pY1
Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.Formula:C104H125N24O29PColore e forma:SolidPeso molecolare:2206.22Lumretuzumab
CAS:<p>Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.</p>Purezza:95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidEGFR-IN-22
CAS:<p>EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) & L858R/T790M/C797S mutation (IC50: 0.54 nM).</p>Formula:C38H47BrFN10O2PColore e forma:SolidPeso molecolare:805.72Ficerafusp alfa
Ficerafusp alfa is a chimeric antibody of the IgG1κ type that targets EGFR, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidDP-C-4
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].Colore e forma:LiquidWAY-270360
CAS:<p>WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.</p>Formula:C22H19N3O3Purezza:98.05%Colore e forma:SolidPeso molecolare:373.4EGFR ligand-11
CAS:<p>EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.</p>Formula:C25H29ClFN5O4Colore e forma:SolidPeso molecolare:517.98Vislarafusp alfa
Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidGW 583340
CAS:GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formula:C28H25ClFN5O3S2Purezza:98.68%Colore e forma:SoildPeso molecolare:598.11EGFR/PI3Kα-IN-1
<p>EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.</p>Formula:C50H49N11O5SColore e forma:SolidPeso molecolare:916.06HER2-IN-14
CAS:HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formula:C26H23ClF2N8O3Colore e forma:SolidPeso molecolare:568.96HER2-IN-13
CAS:HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with anFormula:C26H23ClF2N8O3Colore e forma:SolidPeso molecolare:568.96MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate
CAS:MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Formula:C52H72N12O11Purezza:97.70%Colore e forma:SolidPeso molecolare:1041.2JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Formula:C33H30F4N4O5SColore e forma:SolidPeso molecolare:670.67U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Purezza:>95.0% (SDS-PAGE); 99.6% (SEC-HPLC) - >95.0% (SDS-PAGE); 99.8% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:144.82 kDa (Predicted)Tilatamig
<p>Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.</p>Colore e forma:Odour LiquidAmivantamab (FUT8-KO)
Amivantamab (FUT8-KO) is a humanized dual-specificity antibody targeting EGFR-MET, with FUT8 knocked out, exhibiting immunotherapeutic anticancer activity. This compound inhibits ligand binding, enhances the internalization and degradation of receptor-antibody complexes, and stimulates macrophage-mediated phagocytosis and natural killer cell cytotoxicity, both of which are Fc-dependent.Formula:C13H12O4Colore e forma:LiquidPeso molecolare:232.23Depatuxizumab MMAF
<p>Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.</p>Colore e forma:LiquidPeso molecolare:148.24 kDaHDS 029
CAS:<p>HDS 029 has a wide range of applications in life science related research.</p>Formula:C17H11ClFN5OColore e forma:SolidPeso molecolare:355.76EGFR-IN-128
<p>EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.</p>Formula:C27H20N4OColore e forma:SolidPeso molecolare:416.47PROTAC EGFR degrader 3
CAS:Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Formula:C60H77N13O5SColore e forma:SolidPeso molecolare:1092.4MS9449
CAS:MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.Formula:C60H76ClFN10O8SPurezza:98%Colore e forma:SolidPeso molecolare:1151.82EGFR-IN-43
EGFR-IN-43 (17c) is a potent EGFR inhibitor with ER antagonist action, tamoxifen/endoxifen+gefitinib linkage, and strong anticancer activity.Formula:C50H55ClFN5O5Colore e forma:SolidPeso molecolare:860.45EGFR-IN-129
EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.Formula:C21H18N4O3SColore e forma:SolidPeso molecolare:406.46Pimurutamab
CAS:Pimurutamab, a humanized IgG1-κ antibody, selectively targets the epidermal growth factor receptor (EGFR) and is primarily produced by CHO-K1 cells [1].Purezza:98%Colore e forma:LiquidEGFR-IN-162
<p>EGFR-IN-162 (compound 20) is an effective EGFR inhibitor that enhances both early and late apoptosis (EGFR) as well as necrosis (necrosis). It shows potential for use in breast cancer research.</p>Formula:C27H31N3O2Colore e forma:SolidPeso molecolare:429.24163YH32367
<p>YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.</p>Colore e forma:Odour LiquidDSPE-PEG2000-GE11
<p>DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.</p>Colore e forma:Odour SolidMTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Formula:C20H14ClFN6Purezza:98%Colore e forma:SolidPeso molecolare:392.82Azerutamig
Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).Colore e forma:Odour LiquidIBI-334
<p>IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.</p>Colore e forma:Odour LiquidMS9427
CAS:<p>MS9427: PROTAC EGFR degrader, 7.1 nM (WT), 4.3 nM (L858R); targets mutant via UPS and autophagy; inhibits NSCLC cell growth; anticancer research.</p>Formula:C48H58ClFN8O12Colore e forma:SolidPeso molecolare:993.47Nezutatug
CAS:Nezutatug, an anti-HER3 antibody, serves as a research tool in cancer studies [1].Purezza:98%Colore e forma:LiquidAZ14240475
AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.Formula:C23H15ClF2N6O2Colore e forma:SolidPeso molecolare:480.854Zenocutuzumab
CAS:<p>Zenocutuzumab (MCLA-128) is a humanized antibody targeting HER2, used for research on tumors driven by NRG1 gene rearrangement.</p>Purezza:97%Colore e forma:LiquidPROTAC EGFR degrader 2
Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.Formula:C58H72ClFN12O8SColore e forma:SolidPeso molecolare:1151.78pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
CAS:pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate.Formula:C66H110N23O26PPeso molecolare:1672.715Ontuxizumab
CAS:Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 orPurezza:97.91% (SDS-PAGE); 99.85% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.92 kDaAnticancer agent 158
Anticancer agent 158 (compound 7c) demonstrates potent efficacy against various cancer cell lines, with IC50 values of 7.93 μM for HepG-2, 9.28 μM for MDA-MB-Colore e forma:Odour SolidBMS-599626 2HCL(714971-09-2 Free base)
CAS:<p>BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative.</p>Formula:C27H29Cl2FN8O3Purezza:99.11%Colore e forma:Odour SolidPeso molecolare:603.47ErbB-2-binding peptide
CAS:<p>ErbB-2-binding peptide (HER2-binding peptide), a tumor-targeting peptide, holds potential for cancer research applications [1].</p>Formula:C43H60N8O11Colore e forma:SolidPeso molecolare:864.98Opadotina
Opadotina, a small-molecule anvatabart opadotin, exhibits antineoplastic activity [1].Colore e forma:Odour SolidCZY43
<p>CZY43 is an HER3 degrader that effectively induces degradation of HER3 in breast cancer SKBR3 cells in a dose- and time-dependent manner. It efficiently inhibits HER3-dependent signaling and cancer cell growth, outperforming Bosutinib.</p>Formula:C42H53Cl2N5O3Colore e forma:SolidPeso molecolare:746.808PROTAC EGFR degrader 10
CAS:PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.Formula:C49H65ClN10O7SColore e forma:SolidPeso molecolare:973.62EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Formula:C30H36N7O4PColore e forma:SolidPeso molecolare:589.625EGFR-IN-81
EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69Formula:C28H24F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:551.52EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formula:C26H20ClFN4OSColore e forma:SolidPeso molecolare:490.98EGFR-IN-15
CAS:EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.Formula:C24H25BrN6O2Colore e forma:SolidPeso molecolare:509.408Imbotolimod
Imbotolimod, a humanized monoclonal antibody of the immunoglobulin G1-kappa class, exhibits both anti-ERBB2 and antineoplastic activities.Colore e forma:Odour LiquidEGFR-IN-90
EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectivelyPurezza:98%Colore e forma:Odour SolidEGFR kinase inhibitor 3
CAS:EGFR kinase inhibitor 3 (compound 2) serves as a dual-action inhibitor targeting both ATP and allosteric sites of the EGFR kinase, exhibiting potent IC50 values of less than 10 nM for wild-type EGFR, 1.5 nM for the L858R mutation, 0.059 nM for the L858R/T790M mutation, and 0.064 nM for the L858R/T790M/C797S mutation. It is classified as a C-linked inhibitor [1].Formula:C31H25N7O3SPeso molecolare:575.64Istiratumab
CAS:Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.Colore e forma:LiquidCetuximab (PBS)
Cetuximab (PBS) is a human IgG1 monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR), with a dissociation constant (Kd) of 0.201 nM for EGFR as measured by the SPR method. It exhibits potent antitumor activity.Colore e forma:Odour LiquidEGFR-IN-148
<p>EGFR-IN-148 (compound 8c) is a potent EGFR inhibitor with an IC50 of 0.161 μM. It induces G1/S phase arrest and significantly enhances apoptosis in HepG2 cells.</p>Formula:C17H16N4O4SColore e forma:SolidPeso molecolare:372.398PROTAC EGFR degrader 8
CAS:<p>PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells.</p>Formula:C40H46ClN11O5Purezza:98%Colore e forma:SolidPeso molecolare:796.32Coprelotamab
CAS:<p>Coprelotamab (GB-221) is an IgG-κ monoclonal antibody that targets EGFR2, frequently produced in CHO DG44 (Chinese Hamster Ovary) cells [1].</p>Purezza:98%Colore e forma:LiquidEGFRvIII peptide (PEPvIII)
CAS:<p>PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.</p>Formula:C70H111N19O24SPurezza:98%Colore e forma:SolidPeso molecolare:1634.81CN009543V
CAS:CN009543V is an enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways.Formula:C12H12N4O6SColore e forma:SolidPeso molecolare:340.31Modotuximab
CAS:Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Purezza:95.5% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.5% (SDS-PAGE); 99.3% (SEC-HPLC)Colore e forma:LiquidZM 449829
CAS:ZM 449829: Selective JAK3 inhibitor, binds to ATP site. pIC50: 6.8 for JAK3, others < 5.0.Formula:C13H10OPurezza:98%Colore e forma:SolidPeso molecolare:182.222SJF 1528
CAS:Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).Formula:C55H57ClFN7O8SColore e forma:SolidPeso molecolare:1030.61KRAS G12D inhibitor 25
CAS:KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Formula:C56H62ClN11O6Colore e forma:SolidPeso molecolare:1020.62Cinrebafusp alfa
CAS:Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM toPurezza:98%Colore e forma:LiquidTX2-120-1
CAS:TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formula:C26H27N7O2Colore e forma:SolidPeso molecolare:469.54JBJ-07-149
CAS:JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formula:C28H26N6O2SColore e forma:SolidPeso molecolare:510.61FRF-06-057
FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT).Formula:C19H13N3O3SColore e forma:SolidPeso molecolare:363.39EGFR/HER2-IN-15
EGFR/HER2-IN-15 is a dihydropyrimidine and an effective inhibitor of EGFR/HER2. It significantly suppresses EGFRwt activity with an IC50 of 37.21 nM and exhibits anticancer properties.Formula:C28H29N3O6Peso molecolare:503.20564Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidEGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Formula:C42H37N7O5Colore e forma:SolidPeso molecolare:719.79Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Colore e forma:Odour Solid4-Epidoxycycline
CAS:<p>4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.</p>Formula:C22H24N2O8Colore e forma:SolidPeso molecolare:444.44Tyrosine kinase-IN-7
CAS:<p>Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.</p>Formula:C16H15N3OSPurezza:99.93%Colore e forma:SolidPeso molecolare:297.38EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formula:C25H18N4O2Purezza:98%Colore e forma:SolidPeso molecolare:406.44DSPE-PEG5000-GE11
DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.Colore e forma:Odour SolidPetosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Colore e forma:Odour LiquidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidEGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formula:C49H53ClFN5O5Colore e forma:SolidPeso molecolare:846.43Dacomitinib metabolite M2
CAS:Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.Formula:C27H32ClFN6O4SColore e forma:SolidPeso molecolare:591.1Varlitinib Tosylate
CAS:Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).Formula:C36H35ClN6O8S3Purezza:98%Colore e forma:SolidPeso molecolare:811.34AMX-818
<p>AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.</p>Colore e forma:Odour LiquidDuligotuzumab
CAS:Duligotuzumab is a dual-targeting anti-EGFR/HER3 mAb that blocks signaling and induces ADCC for tumors with poor prognosis.Purezza:97.7% (SDS-PAGE); 96.3% (SEC-HPLC) - ≥95% (SDS-PAGE); 95.19% (SEC-HPLC)Colore e forma:LiquidNecitumumab
CAS:Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Purezza:97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5 kDaCetuximab MMAE
<p>Cetuximab-MMAE, an antibody-drug conjugate (ADC), combines an EGFR-targeting antibody with Monomethyl auristatin E (MMAE) to investigate colorectal and head and neck cancers.</p>Colore e forma:LiquidPeso molecolare:150 kDaEGFR-IN-95
<p>EGFR-IN-95 is a derivative of 2,4-diaminonicotinamide. It effectively inhibits the activity of EGFRdel19/T790M/C797S and L858R/T790M/C797S.</p>Formula:C23H28F2N8O3SPeso molecolare:534.19731EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formula:C17H15N7O5SColore e forma:SolidPeso molecolare:429.41EGFR T790M/L858R-IN-9
<p>EGFRT790M/L858R-IN-9 (Compound 8) is an inhibitor targeting the EGFR-L858R/T790M mutations. It effectively inhibits the phosphorylation of the EGFR-L858R/T790M mutant kinase, demonstrating an IC50 value of 0.0064 µM. Additionally, EGFRT790M/L858R-IN-9 can suppress the proliferation of non-small cell lung cancer (NSCLC) cells, making it useful for cancer research.</p>Formula:C26H27N7O3SColore e forma:SolidPeso molecolare:517.603DSPE-PEG1000-GE11
<p>DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.</p>Colore e forma:Odour SolidAnti-ERBB3/HER3 (29Z6)
<p>Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor targeting human ERBB3/HER3.</p>Colore e forma:Odour LiquidEGFR-IN-124
<p>EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.</p>Colore e forma:Odour SolidEGFR-IN-93
EGFR-IN-93 (compound 18) is an allosteric inhibitor of the T790M/L858R double mutant EGFR. It is applicable for research in non-small cell lung cancer (NSCLC).Formula:C22H18FN3O3Peso molecolare:391.13322EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Colore e forma:Odour SolidLyso-Monosialoganglioside GM3
CAS:<p>Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.</p>Formula:C41H74N2O20Colore e forma:SolidPeso molecolare:915.028Gefitinib N-oxide hydrochloride
Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.Formula:C22H24ClFN4O41·5HClColore e forma:SolidPeso molecolare:517.59EGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formula:C27H37FN8O2Colore e forma:SolidPeso molecolare:524.633Grb2 SH2 domain inhibitor 1
Grb2 SH2 Domain Inhibitor 1 is a cyclic cell-penetrating peptide (CPP) featuring a conformationally restricted d-pro-l-pro motif ring (AF Φ Rpprrfq), where ΦColore e forma:Odour SolidTimigutuzumab
CAS:<p>Timigutuzumab (GEXMab73) is a humanized monoclonal antibody designed to target ErbB2, showing potential application in cancer research [1].</p>Colore e forma:LiquidMS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formula:C50H59ClF4N8O14Colore e forma:SolidPeso molecolare:1107.5Simotinib hydrochloride
CAS:Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.Formula:C25H27Cl2FN4O4Colore e forma:SolidPeso molecolare:537.41PROTAC EGFR degrader 11
CAS:<p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>Formula:C49H64ClFN10O7SColore e forma:SolidPeso molecolare:991.61Anticancer agent 271
Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.Colore e forma:Odour SolidMatuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Purezza:95%Colore e forma:LiquidPeso molecolare:145.9 kDaVarlitinib
CAS:Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formula:C22H19ClN6O2SPurezza:99.7%Colore e forma:SolidPeso molecolare:466.94EGFR-IN-116
EGFR-IN-116 (compound 14D) is an antineoplastic agent. It exhibits an IC50 value of 0.103 μM for EGFR, 0.069 μM for VEGFR-2, and 19.74 μM for Topo II.Formula:C26H22N6O2SPeso molecolare:482.1525SJF-1528 hemihydrate
SJF-1528 hemihydrate is the hemihydrate form of SJF-1528. It acts as an EGFR PROTAC degrader, showing activity in OVCAR8 cells with wild-type EGFR and in HeLa cells with exon 20 Ins mutant EGFR, with DC50 values of 39.2 nM and 736.2 nM, respectively. Additionally, SJF-1528 hemihydrate degrades HER2.Formula:C55H57ClFN7O8SH2OPeso molecolare:1047.37675EGFR T790M/L858R-IN-6
CAS:<p>EGFR T790M/L858R-IN-6 (compound 53), classified as a pyrimidine compound, serves as an effective inhibitor of EGFR T790M/L858R, demonstrating 90.88% inhibition of enzyme activity at a concentration of 0.05 μM [1].</p>Formula:C27H27N7O2Colore e forma:SolidPeso molecolare:481.55EGFR-IN-102
CAS:EGFR-IN-102 (compound 6), an orally active EGFR inhibitor, demonstrates an IC 50 of 2 nM and is utilized for research in non-small-cell lung cancer [1].Formula:C37H37F2N7O2SPeso molecolare:681.80EGFR-IN-79
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy.Formula:C23H16ClN3O3Purezza:98%Colore e forma:SolidPeso molecolare:417.84HER2-IN-20
<p>HER2-IN-20 (compound 32) is a potent and selective inhibitor of HER2WT and HER2YVMA, with IC50 values of 49 and 42 nM, respectively. It holds potential for research in non-small cell lung cancer (NSCLC).</p>Formula:C30H27ClFN7O2Peso molecolare:571.18988EGFR-IN-110
<p>EGFR-IN-110 (Compound 6) is a covalent inhibitor of EGFR, demonstrating pIC50 values of 9.2 for the EGFR enzyme and 8.7 for EGFR cells. It exhibits strong efficacy in targeting EGFR and maintains good kinase selectivity.</p>Formula:C22H16ClFN4O2Peso molecolare:422.09458Tephrosin
CAS:Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.Formula:C23H22O7Purezza:98%Colore e forma:SolidPeso molecolare:410.42SOS1/EGFR-IN-2
SOS1/EGFR-IN-2 (Compound 4) functions as a dual inhibitor of SOS1 and EGFR, exhibiting IC50 values of 8.3 and 14.6 nM, respectively. It demonstrates significant antiproliferative effects on cancer cells harboring various KRAS mutations.Formula:C25H29F3N4O3Colore e forma:SolidPeso molecolare:490.52EGFR WT/T790M/L858R-IN-1
EGFRWT/T790M/L858R-IN-1 (compound 10d) is a potent inhibitor of EGFR, demonstrating IC50 values of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. This compound can be utilized in cancer research.Formula:C26H25Cl3N2O3Peso molecolare:518.09308PRMT5/EGFR-IN-1
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 μM and 19.31 μM, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.Formula:C27H22F6N2O2Peso molecolare:520.15855DS06652923
<p>DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.</p>Colore e forma:Odour SolidInetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.Purezza:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Colore e forma:Odour LiquidHER2/neu (654-662) GP2
CAS:Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.Formula:C42H77N9O11Purezza:98%Colore e forma:SolidPeso molecolare:884.11EGFR kinase inhibitor 2
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting the mutations EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S. This compound shows potential in addressing acquired resistance in the treatment of non-small cell lung cancer.Formula:C39H40N6O5Peso molecolare:672.30602EGFR-IN-76
CAS:EGFR-IN-76 is a potent EGFR inhibitor.Formula:C30H30ClFN6O2Purezza:97.02% - 97.72%Colore e forma:SolidPeso molecolare:561.05AG-1478 hydrochloride
CAS:AG1478 HCl is an epidermal growth factor receptor protein inhibitor.Formula:C16H15Cl2N3O2Colore e forma:SolidPeso molecolare:352.21Pertuzumab
CAS:Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Purezza:98.00%Colore e forma:LiquidPeso molecolare:148 kDaMS39N
CAS:<p>MS39N (compound 27) serves as the negative control for MS39, capable of binding to EGFR without causing its degradation.</p>Formula:C55H71ClFN9O7SPeso molecolare:1056.73JAK 3 inhibitor IV
CAS:JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormula:C16H19NOPurezza:98%Colore e forma:SolidPeso molecolare:241.33Oritinib
CAS:<p>Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (</p>Formula:C31H37N7O2Purezza:99.62%Colore e forma:SoildPeso molecolare:539.67EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFormula:C25H20N6O3S2Purezza:98%Colore e forma:SolidPeso molecolare:516.59AV-412 free base
CAS:AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formula:C27H28ClFN6OColore e forma:SolidPeso molecolare:507
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