EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 593 prodotti di "EGFR"
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Tucatinib
CAS:Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formula:C26H24N8O2Purezza:99.05% - 99.96%Colore e forma:SolidPeso molecolare:480.52Ref: TM-T2364
1g1.130,00€2mg35,00€5mg49,00€10mg79,00€25mg124,00€50mg187,00€100mg350,00€500mg825,00€1mL*10mM (DMSO)87,00€Methyl 2,5-dihydroxycinnamate
CAS:<p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>Formula:C10H10O4Purezza:99.60%Colore e forma:CrystallinePeso molecolare:194.18ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formula:C19H16BrFN6O2Purezza:99.12%Colore e forma:SolidPeso molecolare:459.27Mutant EGFR inhibitor
CAS:Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formula:C27H30ClN7O2Purezza:98% - 99.75%Colore e forma:SolidPeso molecolare:520.03Ref: TM-T2705
1mg37,00€2mg52,00€5mg80,00€10mg97,00€25mg168,00€50mg264,00€100mg379,00€500mgPrezzo su richiesta1mL*10mM (DMSO)104,00€HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurezza:99.75% - >99.99%Colore e forma:SolidPeso molecolare:532.08TX1-85-1
CAS:TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formula:C32H36N8O3Purezza:97.16% - 98.12%Colore e forma:SolidPeso molecolare:580.68Alflutinib
CAS:Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formula:C28H31F3N8O2Purezza:99.87%Colore e forma:SolidPeso molecolare:568.59Ref: TM-T22254
1mg60,00€5mg127,00€10mg187,00€25mg376,00€50mg567,00€100mg747,00€200mg1.064,00€1mL*10mM (DMSO)160,00€WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C29H31F3N6O3Purezza:97.65% - 99.95%Colore e forma:SolidPeso molecolare:568.59Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purezza:99.22%Colore e forma:SolidPeso molecolare:561.03Ref: TM-T9072
2mg40,00€5mg60,00€10mg96,00€25mg188,00€50mg354,00€100mg525,00€200mg752,00€1mL*10mM (DMSO)74,00€Naquotinib
CAS:Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFormula:C30H42N8O3Purezza:97.49%Colore e forma:SolidPeso molecolare:562.71Olafertinib
CAS:Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.Formula:C29H28F2N6O2Purezza:98.62% - 99.706%Colore e forma:SolidPeso molecolare:530.57FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Formula:C34H36Cl2N8O4Purezza:97.63% - 98.92%Colore e forma:SolidPeso molecolare:691.61WZ8040
CAS:<p>WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).</p>Formula:C24H25ClN6OSPurezza:97.42% - 99.785%Colore e forma:SolidPeso molecolare:481.01ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Formula:C16H13NO2Purezza:99.45% - 99.55%Colore e forma:SolidPeso molecolare:251.28Chrysophanol
CAS:Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formula:C15H10O4Purezza:99.44% - 99.91%Colore e forma:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CPeso molecolare:254.24AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3SYR127063
CAS:<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Formula:C23H20ClF3N4O3Purezza:98.57%Colore e forma:SolidPeso molecolare:492.88AZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formula:C31H33ClFN5O11Purezza:99.92%Colore e forma:SolidPeso molecolare:706.1Ref: TM-T8751
1mg62,00€5mg125,00€10mg180,00€25mg298,00€50mg419,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)178,00€CP-724714
CAS:<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Formula:C27H27N5O3Purezza:97.1% - 98.82%Colore e forma:SolidPeso molecolare:469.54PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formula:C18H14ClFN4O2Purezza:97.71%Colore e forma:SolidPeso molecolare:372.78Ref: TM-T22396
2mg40,00€5mg60,00€10mg92,00€25mg187,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purezza:97.93% - 99.94%Colore e forma:SolidPeso molecolare:569.58CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formula:C18H13BrN4OPurezza:99.56% - 99.62%Colore e forma:SolidPeso molecolare:381.23Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purezza:97.18%Colore e forma:SolidPeso molecolare:308.33Ref: TM-T22450
1mg39,00€5mg82,00€10mg115,00€25mg192,00€50mg264,00€100mg380,00€200mg515,00€1mL*10mM (DMSO)90,00€lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purezza:98.06%Colore e forma:Yellow To Tan PowderPeso molecolare:275.26Ref: TM-T4185
1mg44,00€2mg58,00€5mg87,00€10mg160,00€25mg349,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)95,00€Canertinib
CAS:Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formula:C24H25ClFN5O3Purezza:98% - >99.99%Colore e forma:White Or Similar To White Crystalline PowderPeso molecolare:485.94AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H15ClIN3O2Purezza:98.64%Colore e forma:SolidPeso molecolare:443.66Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formula:C18H24N2OSPurezza:99.05%Colore e forma:SolidPeso molecolare:316.46Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Formula:C8H4Cl2N2O2Purezza:97.55%Colore e forma:SolidPeso molecolare:231.04Ref: TM-T4612
5mg57,00€10mg69,00€25mg119,00€50mg216,00€100mg323,00€200mg470,00€500mg752,00€1mL*10mM (DMSO)63,00€Cetuximab
CAS:Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).Formula:C107H179N35O36S7Purezza:95 - 98.60%Colore e forma:LiquidPeso molecolare:152 kDaEndoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formula:C25H27NO2Purezza:99.19% - 99.81%Colore e forma:SolidPeso molecolare:373.49Ref: TM-T2280
1mg35,00€5mg70,00€10mg93,00€25mg170,00€50mg274,00€100mg410,00€200mg595,00€1mL*10mM (DMSO)80,00€Mubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formula:C25H23F3N4O2Purezza:98.61% - 99.85%Colore e forma:SolidPeso molecolare:468.47Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formula:C24H26N6O2Colore e forma:SolidPeso molecolare:430.5AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formula:C16H14IN3O2Purezza:98.61% - 99.23%Colore e forma:SolidPeso molecolare:407.21E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurezza:99.31% - 99.87%Colore e forma:SolidPeso molecolare:474.44Derazantinib dihydrochloride
CAS:Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Formula:C29H31Cl2FN4OColore e forma:SolidPeso molecolare:541.49Tyrphostin AG 528
CAS:Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formula:C18H14N2O3Purezza:99.64%Colore e forma:SolidPeso molecolare:306.32AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurezza:98.12%Colore e forma:SolidPeso molecolare:254.33TAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFormula:C26H32N8O3Purezza:97.78%Colore e forma:SolidPeso molecolare:504.58Ref: TM-T7819
1mg50,00€5mg111,00€10mg170,00€25mg321,00€50mg512,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)117,00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formula:C24H26N4O3Purezza:99.90%Colore e forma:SolidPeso molecolare:418.49Ref: TM-T16343
1mg59,00€5mg111,00€10mg173,00€25mg298,00€50mg393,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)123,00€Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purezza:99.67%Colore e forma:SolidPeso molecolare:442.51(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Formula:C10H8N2O3Purezza:99.23%Colore e forma:SolidPeso molecolare:204.18JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formula:C16H11BrFN3O2Purezza:99.5%Colore e forma:SolidPeso molecolare:376.18PKI-166 hydrochloride
CAS:EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Formula:C20H19ClN4OColore e forma:SolidPeso molecolare:366.85SU 4313
CAS:SU 4313 is a bioactive chemical.Formula:C18H17NOPurezza:99.51% - 99.89%Colore e forma:SolidPeso molecolare:263.33Ref: TM-T3568
1mg35,00€5mg70,00€10mg97,00€25mg170,00€50mg250,00€100mg373,00€200mg547,00€1mL*10mM (DMSO)78,00€EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Formula:C23H21N3O3Purezza:99.55%Colore e forma:SolidPeso molecolare:387.43Ref: TM-T21954
1mg52,00€5mg99,00€10mg148,00€25mg259,00€50mg390,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)109,00€Oritinib mesylate
CAS:Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.Formula:C32H41N7O5SColore e forma:SolidPeso molecolare:635.78Theliatinib tartrate
CAS:Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.Formula:C29H32N6O8Colore e forma:SolidPeso molecolare:592.6AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purezza:98% - >99.99%Colore e forma:SolidPeso molecolare:440.58Ref: TM-T2116
2mg47,00€5mg70,00€10mg103,00€25mg188,00€50mg325,00€100mg490,00€500mg1.103,00€1mL*10mM (DMSO)77,00€
