Chinasi di serina/treonina
Gli inibitori delle chinasi serina/treonina sono composti che prendono di mira gli enzimi responsabili della fosforilazione dei residui di serina e treonina sulle proteine, i quali svolgono un ruolo cruciale nella regolazione dell'apoptosi e di altri processi cellulari. Queste chinasi sono coinvolte in vie di segnalazione che controllano la crescita, la divisione e la morte cellulare programmata. Inibire specifiche chinasi serina/treonina può alterare l'equilibrio tra sopravvivenza cellulare e apoptosi, rendendo questi inibitori strumenti essenziali nella ricerca sul cancro e in altre aree della biologia cellulare. Presso CymitQuimica, offriamo una selezione completa di inibitori delle chinasi serina/treonina di alta qualità per supportare la tua ricerca in apoptosi, trasduzione del segnale e meccanismi delle malattie.
Trovati 23 prodotti per "Chinasi di serina/treonina".
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CRA-2059
CAS:CRA-2059 is a selective and reversible inhibitor of human tryptase beta, exhibiting a Ki value of 620 pM against recombinant human tryptase beta (rHTβ).Formula:C34H46N12O8Purezza:97.68% - 99.29%Colore e forma:White SolidPeso molecolare:750.82MARK4 inhibitor 3
MARK4 inhibitor 3 is a selective MARK4 inhibitor (IC₅₀=1.01 μM) that suppresses cancer cell proliferation for cancer and neurodegeneration studies.Formula:C33H27FN4O3Purezza:99.47%Colore e forma:SolidPeso molecolare:546.59MASTL-IN-2
CAS:MASTL-IN-2 is a MASTL kinase inhibitor. MASTL-IN-2 inhibits MIA PaCa pancreatic cancer cell proliferation with an IC50 of 2.8 nM.Formula:C21H25N7O2Colore e forma:Odour SolidPeso molecolare:407.471,8-Diazanaphthalene
CAS:1,8-Diazanaphthalene inhibits Protein Kinase B with a binding constant Ka=407 μM.Formula:C8H6N2Colore e forma:SolidPeso molecolare:130.1466Tilpisertib
CAS:Tilpisertib is a serine/threonine kinase inhibitor (WO2017007689).Formula:C33H33ClN8OPurezza:99.88%Colore e forma:SolidPeso molecolare:593.121SGC-GAK-1
CAS:SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).Formula:C18H17BrN2O3Purezza:99.85%Colore e forma:Yellow SolidPeso molecolare:389.243PKD-IN-1
CAS:CRT0066101 is an inhibitor of PKD.Formula:C18H19ClN4OPurezza:98%Colore e forma:SolidPeso molecolare:342.82kb NB 142-70
CAS:kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).Formula:C11H9NO2S2Purezza:98.01% - ≥95%Colore e forma:SolidPeso molecolare:251.32CID755673
CAS:CID755673 inhibits PKD (IC50: 182 nM), with selectivity over PLK1, AKT, CAMKIIα, CAK, PKC.Formula:C12H11NO3Purezza:97.68% - 99.84%Colore e forma:SolidPeso molecolare:217.2206MLCK inhibitor peptide 18 acetate
MLCK inhibitor peptide 18 acetate: Selective (IC50=50nM), 4000x more than CaM kinase II. Does not block PKA. Cell-permeable.Formula:C62H109N23O13Purezza:99.90%Colore e forma:SolidPeso molecolare:1384.67SRPIN340
CAS:SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).Formula:C18H18F3N3OPurezza:99.79% - 99.96%Colore e forma:White SolidPeso molecolare:349.35CID 2011756
CAS:CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.Formula:C22H21ClN2O3Purezza:98.15% - ≥95%Colore e forma:SolidPeso molecolare:396.867SPHINX31
CAS:SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).Formula:C27H24F3N5O2Purezza:99.3% - 99.87%Colore e forma:SolidPeso molecolare:507.507GAK inhibitor 49
CAS:GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).Formula:C20H22N2O5Purezza:98.71%Colore e forma:SolidPeso molecolare:370.39911-Naphthyl PP1
CAS:1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)Formula:C19H19N5Purezza:99.85%Colore e forma:SolidPeso molecolare:317.39TLK1-IN-1
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM for TLK1B and a GI50 of 2.7 μM for LNCaP cells. It induces DNA damage and apoptosis (Apoptosis) in cancer cells and is applicable in prostate cancer research.Formula:C24H23BrClN5O3Colore e forma:SolidPeso molecolare:544.83SRPKIN-1
CAS:SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).Formula:C27H21FN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:472.531Ofirnoflastum
CAS:Ofirnoflastum (Ofirnoflast) is a selective serine/threonine-protein kinase Nek7 inhibitor that exerts potent anti-inflammatory effects by suppressing Nek7-dependent NLRP3 inflammasome activation, reducing caspase-1 cleavage, IL-1β and IL-18 secretion, and pyroptotic cell death in vitro, while significantly attenuating cytokine production and tissue injury in animal models of acute and chronic inflammation, supporting its therapeutic potential in autoimmune and inflammatory diseases.Formula:C23H19F4N7O2Purezza:99.87%Colore e forma:SolidPeso molecolare:501.44MKI-3
CAS:MKI-3 is a highly selective MASTL inhibitor with a quinazoline scaffold (IC50 5.72 nM), can inhibit ENSA phosphorylation and activate PP2A, and exhibits antiproliferative and in vivo antitumor activity in breast cancer models.Formula:C21H19N7OPeso molecolare:385.423-IN-PP1
CAS:3-IN-PP1 is a potent inhibitor of PKD1, PKD2, and PKD3 (IC50 = 108, 94, and 108 nM, respectively), acting as a broad-spectrum anticancer agent.Formula:C17H18N6Colore e forma:SolidPeso molecolare:306.365
