Caspasi
Gli inibitori delle caspasi sono composti che bloccano l'attività delle caspasi, una famiglia di proteasi che sono esecutori centrali dell'apoptosi. Le caspasi clivano substrati specifici all'interno della cellula per innescare il processo apoptotico, portando alla morte cellulare programmata. Gli inibitori delle caspasi sono utilizzati per studiare i meccanismi dell'apoptosi, nonché per prevenire la morte cellulare indesiderata in vari modelli di ricerca. Questi inibitori sono anche esplorati in contesti terapeutici per proteggere le cellule dall'apoptosi in malattie come la neurodegenerazione. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle caspasi di alta qualità per supportare la tua ricerca in apoptosi, morte cellulare e campi correlati.
Trovati 143 prodotti di "Caspasi"
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BC-1471
CAS:BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.Formula:C27H32N4O4SPurezza:99.98%Colore e forma:SolidPeso molecolare:508.63Dehydrocorydaline nitrate
CAS:DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formula:C22H24N2O7Purezza:99.79% - 99.92%Colore e forma:SolidPeso molecolare:428.44Dehydrotrametenolic acid
CAS:Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation inFormula:C31H48O3Purezza:98%Colore e forma:SolidPeso molecolare:468.71Limonin glucoside
CAS:Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.Formula:C32H42O14Colore e forma:SolidPeso molecolare:650.674Caspase-3-IN-1
CAS:<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Formula:C26H25N3O6SColore e forma:SolidPeso molecolare:507.56OT-82
CAS:OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.Formula:C26H21FN4OPurezza:98.91% - 99.315%Colore e forma:SolidPeso molecolare:424.47p-nitro-Pifithrin-α
CAS:p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.Formula:C15H16BrN3O3SColore e forma:SolidPeso molecolare:398.27VRT-043198
CAS:VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.Formula:C22H29ClN4O6Colore e forma:SolidPeso molecolare:480.94GRI977143
CAS:<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formula:C22H17NO4SPurezza:98.07%Colore e forma:SolidPeso molecolare:391.44AD-2646
CAS:AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.Formula:C23H40N2O4Colore e forma:SolidPeso molecolare:408.57Tigilanol tiglate
CAS:Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.Formula:C30H42O10Purezza:98%Colore e forma:SolidPeso molecolare:562.65N1,N11-Diethylnorspermine
CAS:DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.Formula:C13H32N4Colore e forma:SolidPeso molecolare:244.42ZYZ-488
CAS:ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.Formula:C20H29N3O11Purezza:99.04%Colore e forma:SolidPeso molecolare:487.46SDZ 224-015
CAS:SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.Formula:C30H35Cl2N3O9Purezza:95.49% - 95.49%Colore e forma:SolidPeso molecolare:652.52Anisperimus
CAS:<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Formula:C18H39N7O3Purezza:98.10%Colore e forma:SolidPeso molecolare:401.552-chloro Palmitic Acid
CAS:2-chloro Palmitic acid triggers NETosis, elevates COX-2, adhesion molecules in HCAECs, and induces apoptosis and caspase-3 in THP-1 cells/monocytes.Formula:C16H31ClO2Colore e forma:SolidPeso molecolare:290.87QM31
CAS:QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).Formula:C39H38Cl4N4O4Purezza:98%Colore e forma:SolidPeso molecolare:768.56CAY10406
CAS:CAY10406, a trifluoromethyl isatin sulfonamide, selectively targets and inhibits caspase-3 and -7, key in apoptosis, with no data on its inhibition potency.Formula:C27H23F3N2O5SColore e forma:SolidPeso molecolare:544.54ML132
CAS:ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).Formula:C22H28ClN5O5Colore e forma:SolidPeso molecolare:477.94S1QEL1.1
CAS:S1QEL1.1 (S1QEL) is an electron leakage inhibitor that inhibits O2-induced ROS generation and prevents O2-induced DA closure.Formula:C23H24N4O3SPurezza:99.93%Colore e forma:SolidPeso molecolare:436.53Caspase-9 Inhibitor III
CAS:Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.Formula:C24H35ClN6O9Colore e forma:SolidPeso molecolare:587.02CZL55
CAS:<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Formula:C20H22N2O6Purezza:98.19%Colore e forma:SolidPeso molecolare:386.4CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formula:C23H26O5Purezza:97.07%Colore e forma:SolidPeso molecolare:382.45EP1013
CAS:EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.Formula:C18H23FN2O6Purezza:98%Colore e forma:SolidPeso molecolare:382.38M190S
CAS:M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.Formula:C21H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:375.42Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formula:C14H23N3O6Purezza:98%Colore e forma:SolidPeso molecolare:329.35M867
CAS:M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Formula:C27H43N7O6Purezza:98%Colore e forma:SolidPeso molecolare:561.67NLRP3 agonist 1
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Formula:C15H16N6Purezza:99.01%Colore e forma:SolidPeso molecolare:280.33GDC-2394
CAS:GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.Formula:C20H25N5O4SColore e forma:SolidPeso molecolare:431.51Ac-YVAD-pNA
CAS:Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].Formula:C29H36N6O10Colore e forma:SolidPeso molecolare:628.639Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formula:C30H37ClN4O9Purezza:98%Colore e forma:SolidPeso molecolare:633.09Ac-Asp-Glu-Val-Asp-pNA
CAS:Ac-Asp-Glu-Val-Asp-pNA is a peptide substrate for caspase-3/7.Formula:C26H34N6O13Peso molecolare:638.58Neuroprotective agent 11
CAS:Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Formula:C32H30O12Colore e forma:SolidPeso molecolare:606.57N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS:N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.Formula:C14H22Cl2N2O3SPeso molecolare:369.31M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFormula:C28H45N7O6Purezza:98%Colore e forma:SolidPeso molecolare:575.7DeFer-2
CAS:DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formula:C44H69N5O5SColore e forma:SolidPeso molecolare:780.11NLRP3-IN-81
CAS:NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.Formula:C16H15F3N2O3SColore e forma:SolidPeso molecolare:372.36Z-VAD-AMC
CAS:Z-VAD-AMC acts as a substrate specifically for caspase-9.Formula:C30H34N4O9Peso molecolare:594.61GlcNAc-MurNAc
CAS:GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.Formula:C19H32N2O13Colore e forma:SolidPeso molecolare:496.46Caspase-3-IN-2
CAS:Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Formula:C10H6ClNO5Colore e forma:SolidPeso molecolare:255.611Ac-DMLD-CMK
CAS:Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.Formula:C22H35ClN4O9SColore e forma:SolidPeso molecolare:567.053Z-VA-DL-D-FMK
CAS:Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Formula:C21H28FN3O7Colore e forma:SolidPeso molecolare:453.46ZIF-8
CAS:<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formula:C4H6N2ZnColore e forma:SolidPeso molecolare:147.513
