Caspasi
Gli inibitori delle caspasi sono composti che bloccano l'attività delle caspasi, una famiglia di proteasi che sono esecutori centrali dell'apoptosi. Le caspasi clivano substrati specifici all'interno della cellula per innescare il processo apoptotico, portando alla morte cellulare programmata. Gli inibitori delle caspasi sono utilizzati per studiare i meccanismi dell'apoptosi, nonché per prevenire la morte cellulare indesiderata in vari modelli di ricerca. Questi inibitori sono anche esplorati in contesti terapeutici per proteggere le cellule dall'apoptosi in malattie come la neurodegenerazione. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle caspasi di alta qualità per supportare la tua ricerca in apoptosi, morte cellulare e campi correlati.
Trovati 143 prodotti di "Caspasi"
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Biotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Colore e forma:Odour SolidVCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Colore e forma:Odour SolidIRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formula:C22H24N4O4SPurezza:99.88%Colore e forma:SolidPeso molecolare:440.52Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Colore e forma:SolidPeso molecolare:952.77Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Colore e forma:Odour SolidRoxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Formula:C17H26N2O3Colore e forma:SolidPeso molecolare:306.4Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidBOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26(Iso)-Z-VAD(OMe)-FMK
CAS:(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formula:C22H30FN3O7Purezza:97.10%Colore e forma:SoildPeso molecolare:467.49Ac-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purezza:99.16%Colore e forma:SolidPeso molecolare:725.67PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Colore e forma:SolidPeso molecolare:695.742TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Colore e forma:SolidPeso molecolare:987.19Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purezza:98%Colore e forma:SolidPeso molecolare:523.54Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formula:C12H13ClN2OPurezza:99.4% - 99.97%Colore e forma:SolidPeso molecolare:236.7Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Formula:C22H36N4O9Colore e forma:SolidPeso molecolare:500.54Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purezza:98%Colore e forma:SolidPeso molecolare:763.78Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Colore e forma:SolidPeso molecolare:611.6IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43
