Caspasi
Gli inibitori delle caspasi sono composti che bloccano l'attività delle caspasi, una famiglia di proteasi che sono esecutori centrali dell'apoptosi. Le caspasi clivano substrati specifici all'interno della cellula per innescare il processo apoptotico, portando alla morte cellulare programmata. Gli inibitori delle caspasi sono utilizzati per studiare i meccanismi dell'apoptosi, nonché per prevenire la morte cellulare indesiderata in vari modelli di ricerca. Questi inibitori sono anche esplorati in contesti terapeutici per proteggere le cellule dall'apoptosi in malattie come la neurodegenerazione. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle caspasi di alta qualità per supportare la tua ricerca in apoptosi, morte cellulare e campi correlati.
Trovati 157 prodotti per "Caspasi".
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
VCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Colore e forma:Odour SolidRoxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Formula:C17H26N2O3Colore e forma:SolidPeso molecolare:306.4BOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)132,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formula:C31H43N9O14Colore e forma:SolidPeso molecolare:765.73Ac-AAVALLPAVLLALLAPVAD-CHO TFA
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a complex of Ac-VAD-CHO. It acts as a non-selective caspase inhibitor and features a hydrophobic sequence derived from K-FGF that enables cell penetration.CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formula:C28H28N2O6SColore e forma:SolidPeso molecolare:520.6Trehalose-6,6'-dibehenate
CAS:Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formula:C56H106O13Colore e forma:SolidPeso molecolare:987.43Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.Formula:C12H13ClN2OPurezza:99.4% - 99.97%Colore e forma:SolidPeso molecolare:236.7Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidRef: TM-L1100
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaTD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Colore e forma:SolidPeso molecolare:987.19Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Colore e forma:SolidPeso molecolare:952.77IRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43Ac-AAVALLPAVLLALLAP-YVAD-CHO
CAS:Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formula:C97H160N20O24Purezza:98%Colore e forma:SolidPeso molecolare:1990.43TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47Ac-IETD-AFC TFA
Ac-IETD-AFC TFA is a synthetic fluorescent substrate used for the specific detection of Caspase-8 enzyme activity. It contains the fluorescent group AFC (7-amino-4-trifluoromethylcoumarin), which becomes free and emits fluorescence (Ex=~400 nm; Em=~505 nm) when Caspase-8 cleaves the amide bond following the IETD sequence. [INDO 1 pentasodium].Colore e forma:Odour SolidDiethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormula:C13H36Cl4N4Purezza:99.79% - 99.86%Colore e forma:SolidPeso molecolare:390.26Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formula:C38H44O12Purezza:98%Colore e forma:SolidPeso molecolare:692.75δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purezza:99.57% - 99.84%Colore e forma:Red SolidPeso molecolare:220.23Almorexant hydrochloride
CAS:Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.Formula:C29H32ClF3N2O3Purezza:99.85%Colore e forma:White SolidPeso molecolare:549.02Tripeptide-32
CAS:Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].Formula:C12H22N4O5Purezza:98%Colore e forma:SolidPeso molecolare:302.33
