Integrina
Gli inibitori delle integrine prendono di mira le integrine, una famiglia di recettori di superficie cellulare che svolgono un ruolo cruciale nell'adesione cellulare, nella migrazione e nella trasduzione del segnale. Le integrine sono coinvolte nella regolazione del ciclo cellulare, in particolare in processi come la divisione e la differenziazione cellulare. L'inibizione delle integrine può interrompere questi processi, portando all'arresto del ciclo cellulare e all'apoptosi, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro e nello studio delle metastasi. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle integrine di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la biologia del cancro e lo sviluppo terapeutico.
Trovati 256 prodotti di "Integrina"
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Surovatamig
Surovatamig is a bispecific antibody of the (H-γ4_L-κ)_VH-G4(h-CH2-CH3) type, targeting CD3D/CD3E/CD19.MORF-627
CAS:MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.Formula:C31H40FN3O4Peso molecolare:537.67YRGDS Fibronectin Fragment
CAS:This is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets. It is RGD consisting of sequence.Formula:C24H36N8O10Purezza:98%Colore e forma:SolidPeso molecolare:596.59Arg-Gly-Glu-Ser TFA
Arg-Gly-Glu-Ser TFA, an RGD-related peptide, serves as a control for evaluating the inhibitory activity of RGDS on fibrinogen binding to activated platelets.Formula:C18H30F3N7O10Peso molecolare:561.47αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Formula:C25H32F2N4O3Colore e forma:SolidPeso molecolare:474.54αvβ6-IN-2
<p>αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.</p>Formula:C25H30F3N3O3Colore e forma:SolidPeso molecolare:477.52c(avb6)-DOTA TFA
c(avb6)-DOTA TFA is a conjugate formed by the coupling of a selective αvβ6 integrin cyclic peptide and a DPTA chelating agent. The Lu (III) complex of c(avb6)-DOTA TFA exhibits considerable affinity for αvβ6 integrin (IC50=0.8 nM), making it suitable for tumor diagnostics.Formula:C69H102F3N17O20Colore e forma:SolidPeso molecolare:1546.65Indatuximab
<p>Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.</p>Purezza:>95%Colore e forma:LiquidPeso molecolare:145.5 kDaGRGDSPK
CAS:<p>GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.</p>Formula:C28H49N11O11Purezza:98%Colore e forma:SolidPeso molecolare:715.76C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formula:C78H115N17O17Colore e forma:SolidPeso molecolare:1562.85GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Formula:C29H37N5O2xHClPurezza:99.54%Colore e forma:SolidPeso molecolare:0Azelaoyl PAF
CAS:Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Formula:C33H66NO9PColore e forma:SolidPeso molecolare:651.85Obtustatin triacetate
<p>Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of the</p>Formula:C184H284N52O57S8·3C2H4O2Purezza:99.51%Colore e forma:SolidPeso molecolare:4573.21BT100
<p>BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].</p>Purezza:98%Colore e forma:Odour SolidVolociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Purezza:95%Colore e forma:LiquidAnti-Mouse CD3 Antibody (17A2)
Anti-Mouse CD3 Antibody (17A2) is an IgG2b class antibody of murine origin targeting CD3 and can be used to study TCR signaling and antigen recognition.Colore e forma:Odour LiquidCilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formula:C29H41F3N8O9Colore e forma:SolidPeso molecolare:702.68RGD Trifluoroacetate
CAS:RGD Trifluoroacetate is a tripeptide for cell adhesion, effective on 24 integrins, and widely used for synthetic surface binding.Formula:C14H23F3N6O8Purezza:98%Colore e forma:SoildPeso molecolare:460.36MK-0429
CAS:MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).Formula:C23H29N5O4Colore e forma:SolidPeso molecolare:439.51GPRP
CAS:GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.Formula:C18H31N7O5Colore e forma:White To Off-White PowderPeso molecolare:425.48Lifitegrast sodium
CAS:<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>Formula:C29H23Cl2N2NaO7SPurezza:99.33%Colore e forma:SolidPeso molecolare:637.46OSU-T315
CAS:<p>OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.</p>Formula:C30H30F3N5OPurezza:98.69%Colore e forma:SolidPeso molecolare:533.59Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purezza:97.1% - 99.33%Colore e forma:SolidPeso molecolare:558.70Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C31H43F6N9O12Purezza:95.28% - ≥95%Colore e forma:SolidPeso molecolare:847.72TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purezza:98.98%Colore e forma:SolidPeso molecolare:474.33Carotegrast methyl HCl
CAS:Carotegrast methyl (AJM300/PTC-100) is an oral α4 integrin blocker reducing inflammation and experimental colitis.Formula:C25H20Cl3N3O5Colore e forma:SolidPeso molecolare:548.801Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Formula:C28H43N9O7Purezza:>99.99%Colore e forma:SolidPeso molecolare:617.7Lifitegrast
CAS:<p>Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.</p>Formula:C29H24Cl2N2O7SPurezza:99.39% - 99.66%Colore e forma:SolidPeso molecolare:615.48CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formula:C26H32BrN5O6Purezza:98.05% - 99.83%Colore e forma:SolidPeso molecolare:590.47A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formula:C15H12N2OS2Purezza:98.07% - 98.52%Colore e forma:SolidPeso molecolare:300.4ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:232.24A-286982
CAS:<p>A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.</p>Formula:C24H27N3O4SPurezza:97.81%Colore e forma:SolidPeso molecolare:453.55Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purezza:98.99% - 99.54%Colore e forma:SolidPeso molecolare:717.69GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Formula:C29H37N7O5SPurezza:99.4% - 99.70%Colore e forma:SolidPeso molecolare:595.71Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Purezza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Colore e forma:LiquidPeso molecolare:N/AArginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Formula:C12H22N6O6Purezza:99.11%Colore e forma:SolidPeso molecolare:346.34Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purezza:98% - 99.8%Colore e forma:SolidPeso molecolare:588.66Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formula:C28H26Cl2N4O5Purezza:99.26% - 99.72%Colore e forma:SolidPeso molecolare:569.44Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFormula:C18H16O8Purezza:99.50% - 99.85%Colore e forma:SolidPeso molecolare:360.31Eptifibatide acetate (148031-34-9 free base)
CAS:Eptifibatide acetate (148031-34-9), a cyclic heptapeptide GP IIb/IIIa inhibitor antiplatelet drug.Formula:C35H49N11O9S2·xC2H4O2Purezza:99.7% - 99.87%Colore e forma:SolidPeso molecolare:831.96 (free base)roxifiban
CAS:<p>Roxifiban, a prodrug of XV459, is an antiplatelet agent with high affinity and specificity for platelet glycoprotein IIb/IIIa complex(GPIIb/IIIa) receptors.</p>Formula:C21H29N5O6Purezza:98%Colore e forma:SolidPeso molecolare:447.48Arg-Gly-Asp TFA (99896-85-2(free base))
Arg-Gly-Asp TFA (RGD, 99896-85-2) is a tripeptide that promotes cell adhesion and integrin binding.Formula:C14H23F3N6O8Purezza:99.2% - ≥98%Colore e forma:SolidPeso molecolare:460.36GPRP acetate (67869-62-9 free base)
CAS:<p>GPRP acetate (Pefabloc FG) is fibrinogen-related peptides, which inhibit the interaction of fibrinogen with the platelet membrane glycoprotein IIbIIIa complex.</p>Formula:C20H35N7O7Purezza:>99.99%Colore e forma:SolidPeso molecolare:485.53LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formula:C29H48N12O12S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:820.89BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formula:C36H48N6O9Purezza:99.33%Colore e forma:SolidPeso molecolare:708.8MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Formula:C9H7NO4Purezza:98.53%Colore e forma:Yellow PowderPeso molecolare:193.16Tirofiban hydrochloride monohydrate
CAS:<p>Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.</p>Formula:C22H39ClN2O6SPurezza:98.81% - >99.99%Colore e forma:White SolidPeso molecolare:495.07Orbofiban
CAS:Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.Formula:C17H23N5O4Colore e forma:SolidPeso molecolare:361.4Pyrintegrin
CAS:<p>Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.</p>Formula:C23H25N5O3SPurezza:99.19%Colore e forma:SolidPeso molecolare:451.54H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Formula:C23H38N10O10Purezza:>99.99%Colore e forma:SolidPeso molecolare:614.61
