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Integrina

Integrina

Gli inibitori delle integrine prendono di mira le integrine, una famiglia di recettori di superficie cellulare che svolgono un ruolo cruciale nell'adesione cellulare, nella migrazione e nella trasduzione del segnale. Le integrine sono coinvolte nella regolazione del ciclo cellulare, in particolare in processi come la divisione e la differenziazione cellulare. L'inibizione delle integrine può interrompere questi processi, portando all'arresto del ciclo cellulare e all'apoptosi, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro e nello studio delle metastasi. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle integrine di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la biologia del cancro e lo sviluppo terapeutico.

Trovati 296 prodotti per "Integrina".

prodotti per pagina.
  • AB-3PRGD2
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    AB-3PRGD2

    CAS:
    AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
    Formula:C137H215IN30O45S
    Colore e forma:Solid
    Peso molecolare:3161.32

    Ref: TM-T206427

  • LXY3
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    LXY3

    CAS:
    LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.
    Formula:C32H43N11O15S2
    Colore e forma:Solid
    Peso molecolare:885.88

    Ref: TM-TP3270

  • Logo CymitQuimica
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    R-BC154 acetate

    R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.
    Formula:C56H65N9O14S3
    Colore e forma:Solid
    Peso molecolare:1184.36

    Ref: TM-T74072

  • RTDLDSLRTYTL
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    RTDLDSLRTYTL

    CAS:
    RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.
    Formula:C62H104N18O22
    Colore e forma:Solid
    Peso molecolare:1453.60

    Ref: TM-TP2670

  • Logo CymitQuimica
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    TC113

    TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.
    Formula:C37H50F2N12O13
    Colore e forma:Solid
    Peso molecolare:908.86

    Ref: TM-T74400

  • Gly-Arg-Gly-Asp-Ser
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    Gly-Arg-Gly-Asp-Ser

    CAS:
    Gly-Arg-Gly-Asp-Ser (GRGDS) is a synthetic fibronectin-derived pentapeptide. Its RGD core mediates cell adhesion and inhibits ACE activity.
    Formula:C17H30N8O9
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:490.4683

    Ref: TM-TP1459

  • LDV
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    LDV

    CAS:
    α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.
    Formula:C48H70N10O12
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:979.1292

    Ref: TM-TP2006

  • ICAM-1988
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    ICAM-1988

    CAS:
    ICAM-1988 is a LFA-1 antagonist.
    Formula:C22H22Cl2N4O6S
    Colore e forma:Solid
    Peso molecolare:541.4

    Ref: TM-T24155

  • Logo CymitQuimica
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    HPN536

    HPN536 is a trispecific T-cell activating protein construct that binds to tumor cells expressing mesothelin, the CD3ε on T cells, and serum albumin. It specifically redirects T cells for the potent redirected lysis of cancer cells expressing mesothelin while simultaneously activating T cells.

    Ref: TM-TP3117

  • αVβ8-IN-1
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    αVβ8-IN-1

    CAS:
    αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).
    Formula:C25H32ClN5O4
    Colore e forma:White Solid
    Peso molecolare:502.01

    Ref: TM-T200044

  • αvβ6-BP
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    αvβ6-BP

    αvβ6-BP is a selective αvβ6-binding peptide, useful for research in molecular imaging.
    Formula:C93H164N34O27
    Peso molecolare:2189.25052

    Ref: TM-TP3464

  • Dentonin TFA
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    Dentonin TFA

    Dentonin TFA (AC-100 TFA) is a short peptide fragment derived from MEPE. It enhances osteogenesis by promoting the adhesion of osteoprogenitor cells and supports the survival of immature adherent cells. Dentonin TFA does not have a significant effect on mature osteoblasts and can be utilized in studies of phosphate homeostasis and bone metabolism.
    Formula:C109H161F3N30O44
    Peso molecolare:2651.1235

    Ref: TM-TP3361

  • HSDVHK-NH2
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    HSDVHK-NH2

    CAS:
    Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
    Formula:C30H48N12O9
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:720.78

    Ref: TM-TP1879

  • LT25
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    LT25

    CAS:
    LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.
    Formula:C15H17N3O5
    Colore e forma:Solid
    Peso molecolare:319.31

    Ref: TM-T200959

  • Logo CymitQuimica
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    BGC0222

    BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.
    Formula:C1241H2276N64O552
    Colore e forma:Solid
    Peso molecolare:26927.36

    Ref: TM-T203374

  • BIO 5192
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    BIO 5192

    CAS:
    BIO 5192 is a high-affinity α4β1 (VLA-4) antagonist that mimics the VCAM-1 epitope to block cell adhesion for inflammation and autoimmune disease research.
    Formula:C38H46Cl2N6O8S
    Peso molecolare:817.78

    Ref: TM-T21682

  • Integrin Binding Peptide acetate
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    Integrin Binding Peptide acetate

    Integrin Binding Peptide acetate is a fibronectin-derived peptide that binds integrins, enabling PEG-hydrogel functionalization for cell adhesion.
    Formula:C42H63N15O16S·xC2H4O2
    Purezza:95.03%
    Colore e forma:White Solid
    Peso molecolare:1066.12 (free base)

    Ref: TM-T40361L

  • Obtustatin
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    Obtustatin

    Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.
    Formula:C184H284N52O57S8
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:4393.07

    Ref: TM-TP1974

  • Logo CymitQuimica
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    Echistatin TFA

    Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.
    Colore e forma:Odour Solid

    Ref: TM-T36295

  • Lys-Gln-Ala-Gly-Asp-Val
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    Lys-Gln-Ala-Gly-Asp-Val

    CAS:
    KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.
    Formula:C25H44N8O10
    Colore e forma:Solid
    Peso molecolare:616.66

    Ref: TM-T76376