Integrina
Gli inibitori delle integrine prendono di mira le integrine, una famiglia di recettori di superficie cellulare che svolgono un ruolo cruciale nell'adesione cellulare, nella migrazione e nella trasduzione del segnale. Le integrine sono coinvolte nella regolazione del ciclo cellulare, in particolare in processi come la divisione e la differenziazione cellulare. L'inibizione delle integrine può interrompere questi processi, portando all'arresto del ciclo cellulare e all'apoptosi, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro e nello studio delle metastasi. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle integrine di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la biologia del cancro e lo sviluppo terapeutico.
Trovati 289 prodotti per "Integrina".
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TRAP-14 amide
CAS:TRAP-14 amide is a protease-activated receptor (PAR) activating peptide and acts as a PAR agonist, with an EC50 of 24 μM. It induces significant platelet aggregation via ADP and MMP-2 dependent pathways and is insensitive to Aspirin. Additionally, TRAP-14 amide effectively increases the surface expression of glycoprotein (GP) Ib and GPIIb/IIIa, as well as the release of ADP.Formula:C81H119N21O22Colore e forma:SolidPeso molecolare:1738.94BGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Formula:C1241H2276N64O552Colore e forma:SolidPeso molecolare:26927.36Risuteganib
CAS:Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide that regulates the functions of multiple integrin isoforms.Formula:C22H39N9O11SPurezza:98%Colore e forma:SolidPeso molecolare:637.66Lumivatamig
CAS:Lumivatamig is a bispecific antibody targeting CLDN18.2 and CD3E, and is classified as an H-γ1_L-κ-scFvhl dimer.Colore e forma:LiquidICAM-1988
CAS:ICAM-1988 is a LFA-1 antagonist.Formula:C22H22Cl2N4O6SColore e forma:SolidPeso molecolare:541.4Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formula:C46H52Na2O16Purezza:98%Colore e forma:SolidPeso molecolare:906.88MLN2201
MLN2201 is a humanized monoclonal antibody inhibitor that targets Integrinβ2. It can inhibit reperfusion injury following a stroke and is applicable for researching inflammatory conditions such as ischemic stroke.Colore e forma:Odour LiquidGamgertamig
CAS:Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Colore e forma:LiquidPLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Formula:C24H37N3O4Purezza:99.92%Colore e forma:SolidPeso molecolare:431.57Ref: TM-T60101
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg289,00€50mg416,00€100mg580,00€Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1EMD527040
CAS:EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.Formula:C29H32Cl2N4O5Colore e forma:SolidPeso molecolare:587.5Anti-GPRC5D Antibody
Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody targeting GPRC5D. It serves as the antibody component of the ADC molecule LM-305.Colore e forma:Odour LiquidFradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Formula:C20H22ClN3O4Colore e forma:SolidPeso molecolare:403.86BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Colore e forma:SolidR-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Formula:C56H65N9O14S3Colore e forma:SolidPeso molecolare:1184.36Arg-Gly-Glu-Ser
CAS:Arg-Gly-Glu-Ser is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets.Formula:C16H29N7O8Purezza:98%Colore e forma:SolidPeso molecolare:447.44Fibrinogen Binding Inhibitor Peptide
CAS:Synthetic dodecapeptide mimics human fibrinogen g-chain, inhibits platelet receptor (residues 400-411).Formula:C50H80N18O16Purezza:98%Colore e forma:SolidPeso molecolare:1189.28SAN-300
SAN-300 is a human-derived IgG1 monoclonal antibody (mAb) that targets ITGA1/VLA-1. It is utilized in the research of rheumatoid arthritis.Colore e forma:Odour LiquidIntegrin Binding Peptide acetate
Integrin Binding Peptide acetate is a fibronectin-derived peptide that binds integrins, enabling PEG-hydrogel functionalization for cell adhesion.Formula:C42H63N15O16S·xC2H4O2Purezza:95.03%Colore e forma:White SolidPeso molecolare:1066.12 (free base)Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Colore e forma:Odour Solid
