Ferroptosi
La ferroptosi è una forma di morte cellulare regolata caratterizzata dall'accumulo di perossidi lipidici e dallo stress ossidativo dipendente dal ferro. A differenza dell'apoptosi, la ferroptosi non è guidata dalle caspasi, ma piuttosto dal fallimento delle difese antiossidanti cellulari, che porta alla morte cellulare. Gli inibitori e gli induttori della ferroptosi sono fondamentali per studiare questa particolare via di morte cellulare, implicata in varie malattie, tra cui il cancro, la neurodegenerazione e il danno da ischemia-riperfusione. Presso CymitQuimica, offriamo una vasta gamma di modulatori della ferroptosi di alta qualità per supportare la tua ricerca sui meccanismi di morte cellulare, stress ossidativo e patologia delle malattie.
Trovati 226 prodotti di "Ferroptosi"
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ZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS:Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Formula:C20H14ClFeN2O2Colore e forma:SolidPeso molecolare:405.64CQ-ER
CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).Formula:C33H33N7O6SColore e forma:SolidPeso molecolare:655.72W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formula:C25H20F3N5O6Purezza:98.1%Colore e forma:SolidPeso molecolare:543.45Ref: TM-T80847
1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg1.008,00€100mg1.596,00€1mL*10mM (DMSO)Prezzo su richiesta84-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Formula:C25H22F3NO5Purezza:99.76%Colore e forma:SolidPeso molecolare:473.44Ref: TM-T75268
1mg49,00€5mg97,00€10mg160,00€25mg305,00€50mg472,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)97,00€Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Purezza:98%Colore e forma:Odour SolidGPX4-IN-7
<p>GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.</p>Formula:C25H23ClN4O4Purezza:98%Colore e forma:SolidPeso molecolare:478.93Ferroptosis-IN-1
Ferroptosis-IN-1, a diterpene derived from A.Formula:C22H34O5Purezza:98%Colore e forma:SolidPeso molecolare:378.5Idebenone
CAS:Formula:C19H30O5Purezza:>98.0%(T)(HPLC)Colore e forma:Light yellow to Brown powder to crystalPeso molecolare:338.44Cerivastatin sodium
CAS:Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.Formula:C26H33FNNaO5Purezza:98.50% - 99.67%Colore e forma:SolidPeso molecolare:481.53CuATSP
CAS:CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.Formula:C18H18CuN6S2Purezza:97.09%Colore e forma:SolidPeso molecolare:446.05CuATSM
CAS:Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.Formula:C8H14CuN6S2Colore e forma:SolidPeso molecolare:321.92CCW16
CAS:CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.Formula:C22H20ClNO3Purezza:97%Colore e forma:SolidPeso molecolare:381.85BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:525.53Ref: TM-T2488
1mg35,00€2mg43,00€5mg63,00€10mg101,00€25mg212,00€50mg351,00€100mg588,00€1mL*10mM (DMSO)73,00€UAMC-3203 hydrochloride
CAS:UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.Formula:C25H38ClN5O2SPurezza:99.62%Colore e forma:SolidPeso molecolare:508.12Ref: TM-T8662
1mgPrezzo su richiesta2mg49,00€5mg80,00€10mg111,00€25mg160,00€50mg202,00€100mg283,00€200mg419,00€1mL*10mM (DMSO)89,00€Baicalein monohydrate
CAS:Baicalein monohydrate blocks 12-lipoxygenase, curbs leukotrienes, lysosomal enzymes, Ca2+ dynamics, and fights arthritis.Formula:C15H12O6Colore e forma:SolidPeso molecolare:288.25TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purezza:99.17% - 99.53%Colore e forma:White Solid PowderPeso molecolare:166.22Ferrostatin-1
CAS:Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death, potently inhibits Erastin-induced iron death in HT-1080 cells. High-Quality, Low-Cost!Formula:C15H22N2O2Purezza:96.1% - 99.68%Colore e forma:SolidPeso molecolare:262.35NADPH tetrasodium salt
CAS:NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety ofFormula:C21H26N7Na4O17P3Purezza:97.15% - >99.99%Colore e forma:SolidPeso molecolare:833.35L-Glutamic acid monosodium salt
CAS:L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.Formula:C5H8NO4·NaPurezza:99.93%Colore e forma:White Solid CrystallinePeso molecolare:169.11Coenzyme Q10
CAS:Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.Formula:C59H90O4Purezza:99.14% - 99.88%Colore e forma:DrypowderPeso molecolare:863.34SP-420
CAS:SP-420 is a novel orally active iron chelator.Formula:C16H21NO6SPurezza:99.39%Colore e forma:SolidPeso molecolare:355.41ML-210
CAS:ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.Formula:C22H20Cl2N4O4Purezza:97% - 99.03%Colore e forma:SolidPeso molecolare:475.32Ref: TM-T8375
1mg35,00€2mg52,00€5mg87,00€10mg140,00€25mg246,00€50mg414,00€100mg557,00€1mL*10mM (DMSO)90,00€Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurezza:98% - 99.8%Colore e forma:Yellow SolidPeso molecolare:441.54Ref: TM-T3170
2mg42,00€5mg62,00€10mg88,00€25mg172,00€50mg305,00€100mg558,00€500mg1.169,00€1mL*10mM (DMSO)85,00€L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS:L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.Formula:C8H18N2O3SPurezza:97.07% - ≥98%Colore e forma:White Fine PowderPeso molecolare:222.31DL-Buthionine-(S,R)-sulfoximine
CAS:DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.Formula:C8H18N2O3SPurezza:98% - 99.64%Colore e forma:White Fine PowderPeso molecolare:222.31SRS16-86
CAS:SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.Formula:C26H32N4O2Purezza:97.73%Colore e forma:SolidPeso molecolare:432.56Ref: TM-T9073
1mg37,00€2mg52,00€5mg77,00€10mg114,00€25mg215,00€50mg324,00€100mg484,00€1mL*10mM (DMSO)94,00€Pseudolaric Acid B
CAS:Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.Formula:C23H28O8Purezza:98.91% - 99.84%Colore e forma:SolidPeso molecolare:432.46Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Formula:C13H15NO2SPurezza:99.76% - 99.94%Colore e forma:White SolidPeso molecolare:249.33Ref: TM-T1934
2mg35,00€5mg50,00€10mg66,00€25mg85,00€50mg124,00€100mg197,00€200mg255,00€1mL*10mM (DMSO)62,00€Levobupivacaine
CAS:Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.Formula:C18H28N2OPurezza:99.72%Colore e forma:SolidPeso molecolare:288.43Ref: TM-T1787
5mg48,00€10mg63,00€25mg93,00€50mg136,00€100mg188,00€200mg283,00€500mg487,00€1mL*10mM (DMSO)49,00€Liproxstatin-1
CAS:Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM).Formula:C19H21ClN4Purezza:97.11% - 99.44%Colore e forma:SolidPeso molecolare:340.85Ref: TM-T2376
1mg39,00€5mg85,00€10mg130,00€25mg244,00€50mg390,00€100mg495,00€200mg712,00€1mL*10mM (DMSO)85,00€Rosiglitazone hydrochloride
CAS:Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.Formula:C18H19N3O3S·HClPurezza:99.63% - 99.79%Colore e forma:SolidPeso molecolare:393.89SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurezza:97.63% - 99.82%Colore e forma:SolidPeso molecolare:220.23NADPH tetracyclohexanamine
CAS:<p>NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.</p>Formula:C45H82N11O17P3Purezza:98.73% - 99.05%Colore e forma:SolidPeso molecolare:1142.12L-Cystine
CAS:<p>L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of</p>Formula:C6H12N2O4S2Purezza:99.59% - 99.85%Colore e forma:White Solid PowderPeso molecolare:240.30Rosiglitazone
CAS:Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.Formula:C18H19N3O3SPurezza:98.61% - 99.87%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:357.43JKE-1674
CAS:JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210.Cost-effective and quality-assured.Formula:C20H20Cl2N4O4Purezza:98.02% - 98.4%Colore e forma:SolidPeso molecolare:451.3Ref: TM-T37314
1mg52,00€5mg111,00€10mg173,00€25mg298,00€50mg464,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)124,00€L-Glutamic acid
CAS:L-Glutamic acid is an agonist of glutamate receptors, including metabotropic glutamate receptors (mGluR), AMPA, NMDA, and KA. High-Quality, Low-Cost!Formula:C5H9NO4Purezza:99.14% - 99.55%Colore e forma:White Solid CrystallinePeso molecolare:147.13ML385
CAS:ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity.Formula:C29H25N3O4SPurezza:98.08% - >99.99%Colore e forma:SolidPeso molecolare:511.59Ref: TM-T4360
5mg51,00€10mg79,00€25mg153,00€50mg243,00€100mg376,00€200mg562,00€500mg899,00€1mL*10mM (DMSO)59,00€Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurezza:99.25% - >99.99%Colore e forma:SolidPeso molecolare:259.33Ref: TM-T1847
5mg35,00€10mg49,00€25mg82,00€50mg113,00€100mg170,00€200mg250,00€500mg419,00€1mL*10mM (DMSO)52,00€Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFormula:C30H32ClFN2OPurezza:99.72% - >99.99%Colore e forma:SolidPeso molecolare:491.04Ref: TM-T1885
1mg60,00€2mg88,00€5mg111,00€10mg173,00€25mg354,00€50mg528,00€100mg743,00€1mL*10mM (DMSO)120,00€Bardoxolone Methyl
CAS:Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-Formula:C32H43NO4Purezza:97.81% - 99.09%Colore e forma:SolidPeso molecolare:505.69Trigonelline
CAS:<p>Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.</p>Formula:C7H7NO2Purezza:97.585% - 99.49%Colore e forma:Prisms Aqueous From Alcohol + Water SolidPeso molecolare:137.14WITHAFERIN A
CAS:WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Formula:C28H38O6Purezza:97.41% - 99.99%Colore e forma:SolidPeso molecolare:470.60Ref: TM-T5687
1mg85,00€5mg265,00€10mg393,00€25mg653,00€50mg929,00€100mg1.254,00€500mg2.517,00€1mL*10mM (DMSO)304,00€PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Formula:C9H15NO3Purezza:99.22%Colore e forma:SolidPeso molecolare:185.22Ref: TM-T6954
5mg51,00€10mg73,00€25mg140,00€50mg207,00€100mg368,00€200mg547,00€500mg877,00€1mL*10mM (DMSO)57,00€Alogliptin Benzoate
CAS:Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.Formula:C25H27N5O4Purezza:99.94% - >99.99%Colore e forma:White PowderPeso molecolare:461.51Alogliptin
CAS:Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9Formula:C18H21N5O2Purezza:99.63%Colore e forma:SolidPeso molecolare:339.39Ref: TM-T6192
2mg35,00€5mg52,00€10mg64,00€25mg86,00€50mg97,00€100mg136,00€200mg188,00€1mL*10mM (DMSO)52,00€Atorvastatin hemicalcium salt
CAS:Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.Formula:C33H34FN2O5CaPurezza:99.27% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:577.67Erastin
CAS:Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner, anti-tumor. High-Quality, Low-Cost!Formula:C30H31ClN4O4Purezza:98% - 99.75%Colore e forma:SolidPeso molecolare:547.04Ref: TM-T1765
1mg48,00€2x1mg63,00€5x1mg87,00€10x1mg127,00€25x1mg202,00€50x1mg300,00€100x1mg444,00€200x1mg652,00€Trolox
CAS:Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.Formula:C14H18O4Purezza:98.90% - 99.90%Colore e forma:White To Fainly Beige Crystalline PowderPeso molecolare:250.29
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