Ferroptosi
La ferroptosi è una forma di morte cellulare regolata caratterizzata dall'accumulo di perossidi lipidici e dallo stress ossidativo dipendente dal ferro. A differenza dell'apoptosi, la ferroptosi non è guidata dalle caspasi, ma piuttosto dal fallimento delle difese antiossidanti cellulari, che porta alla morte cellulare. Gli inibitori e gli induttori della ferroptosi sono fondamentali per studiare questa particolare via di morte cellulare, implicata in varie malattie, tra cui il cancro, la neurodegenerazione e il danno da ischemia-riperfusione. Presso CymitQuimica, offriamo una vasta gamma di modulatori della ferroptosi di alta qualità per supportare la tua ricerca sui meccanismi di morte cellulare, stress ossidativo e patologia delle malattie.
Trovati 225 prodotti di "Ferroptosi"
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Ferroptosis inducer-6
CAS:Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formula:C69H78F12N12P2RuColore e forma:SolidPeso molecolare:1466.44AY-4
AY-4 (Compound AY-4) is a potent PROTAC degrader targeting FTH1, with a dissociation constant (Kd) of 3.17 nM. It effectively increases intracellular ferrous (Fe2+) and ferric (Fe3+) ion levels. AY-4 is a potential anticancer candidate that regulates iron homeostasis through ferritin degradation, enhancing the efficacy of existing drugs. Additionally, AY-4 significantly reduces FTH1 levels in breast cancer cells.Colore e forma:Odour SolidFerumoxytol
CAS:Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.Colore e forma:SolidGDCNF-11
CAS:GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Formula:C48H53Cl2N13O5SColore e forma:SolidPeso molecolare:994.99Ferroptosis-IN-20
Ferroptosis-IN-20 (Compound 34a) is an inhibitor of ferroptosis targeting voltage-dependent anion channels (VDAC) with an EC50 of 24.2 nM. It prevents VDAC oligomerization and lipid peroxidation. Additionally, Ferroptosis-IN-20 reduces ROS levels, diminishes TFR1-mediated iron uptake, inhibits Fe2+ levels, and restores glutathione (GSH) levels. It also alleviates acute kidney injury (AKI) caused by folic acid.Colore e forma:Odour SolidDTUN
<p>DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.</p>Colore e forma:Solid2-Acetamidophenol
CAS:<p>2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).</p>Formula:C8H9NO2Purezza:>99.99%Colore e forma:Light Brown PowderPeso molecolare:151.16VK-28
CAS:VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.Formula:C16H21N3O2Purezza:99.87%Colore e forma:SolidPeso molecolare:287.361R,3R-RSL3
CAS:1R,3R-RSL3 is a negative control for1S, 3R-RSL3.Formula:C23H21ClN2O5Colore e forma:SolidPeso molecolare:440.88CQ-ER
<p>CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).</p>Formula:C33H33N7O6SColore e forma:SolidPeso molecolare:655.72Ferroptosis Compound Library
<p>A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；</p>Colore e forma:Odour Solid1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:<p>Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.</p>Formula:C43H78NO10PColore e forma:SolidPeso molecolare:800.068Anticancer agent 178
Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.Formula:C32H30ClFeN2O6Peso molecolare:629.11418PRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formula:C21H26Cl2N4O2Purezza:98.4% - 99.94%Colore e forma:SolidPeso molecolare:437.37Pro-GA
CAS:Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.Formula:C12H19NO7Colore e forma:SolidPeso molecolare:289.28Ferroptosis-IN-14
Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.Colore e forma:Odour SolidZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFormula:C18H17BrFNO5Purezza:99.54%Colore e forma:SoildPeso molecolare:426.23HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formula:C22H26N4O2SColore e forma:SolidPeso molecolare:410.53
