CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 542 prodotti di "CDK"
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NVP-2
CAS:NVP-2 selectively inhibits CDK9 (IC50: 0.514 nM), prompts apoptosis, and affects other CDKs (IC50: 0.584-0.706 μM).Formula:C27H37ClN6O2Purezza:99.13%Colore e forma:SolidPeso molecolare:513.07Ref: TM-T16363
1mg52,00€2mg74,00€5mg113,00€10mg192,00€25mg416,00€50mg615,00€100mg875,00€1mL*10mM (DMSO)128,00€(R)-CR8
CAS:(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
Formula:C24H29N7OPurezza:98.41%Colore e forma:SolidPeso molecolare:431.53Cyclin K degrader 1
Cyclin K degrader 1 is a Cyclin K degrader.Cyclin K degrader 1 is a degrader converted from AT-7519.Cyclin K degrader 1 has weak degrading activity against Cyclin K but does not result in a sustained decrease in degradation affinity.Cyclin K degrader 1 is a degrader converted from AT-7519.Formula:C23H17Cl2N5O2Purezza:99.76%Colore e forma:SolidPeso molecolare:466.32Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:414.45CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Formula:C27H32F2N8Purezza:99.47%Colore e forma:SolidPeso molecolare:506.59AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Formula:C21H31N5O2Purezza:98.81%Colore e forma:SolidPeso molecolare:385.5Ref: TM-T14367
1mg93,00€5mg156,00€10mg245,00€25mg349,00€50mg494,00€100mg750,00€200mg1.009,00€1mL*10mM (DMSO)170,00€Ca2+ channel agonist 1
CAS:Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.Formula:C19H26N6OPurezza:97.71%Colore e forma:SolidPeso molecolare:354.45Ref: TM-T10659
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€hSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.
Formula:C27H28ClN7O3SPurezza:99.22% - 99.65%Colore e forma:SolidPeso molecolare:566.07(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Formula:C19H18F2N4O2SPurezza:99.29%Colore e forma:SolidPeso molecolare:404.43Ref: TM-T13467
1mg34,00€5mg84,00€10mg114,00€25mg205,00€50mg334,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)93,00€XPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Formula:C36H39ClFN7O2Purezza:98.08%Colore e forma:SoildPeso molecolare:656.19CDKI-73
CAS:CDKI-73: strong CDK9 blocker, Ki 4 nM, kills CLL cells selectively, aids cisplatin.Formula:C15H15FN6O2S2Purezza:98.11%Colore e forma:SolidPeso molecolare:394.45Ref: TM-T14919
1mg136,00€2mg178,00€5mg278,00€10mg399,00€25mg658,00€50mg888,00€100mg1.251,00€1mL*10mM (DMSO)290,00€Samuraciclib hydrochloride
CAS:Samuraciclib HCl is an oral CDK7 inhibitor (IC50: 41 nM), 45-230x selective over CDK1/2/5/9, inhibiting breast cancer growth (GI50: 0.2-0.3 μM).Formula:C22H31ClN6OPurezza:98.99% - 99.8%Colore e forma:SolidPeso molecolare:430.97Ref: TM-T10898
1mg108,00€2mg147,00€5mg222,00€10mg335,00€25mg595,00€50mg847,00€100mg1.153,00€1mL*10mM (DMSO)245,00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Formula:C22H15F2N5OPurezza:99.82%Colore e forma:SoildPeso molecolare:403.38Ref: TM-T77341
1mg315,00€5mg873,00€10mg1.080,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg3.537,00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C27H36N8O5Purezza:99.9%Colore e forma:SolidPeso molecolare:552.63Ref: TM-T15732
2mg34,00€5mg49,00€10mg70,00€25mg92,00€50mg109,00€100mg165,00€200mg258,00€500mg459,00€1mL*10mM (DMSO)60,00€CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formula:C23H18N6O2SPurezza:97.24% - 99.10%Colore e forma:SolidPeso molecolare:442.49Ref: TM-T14916
1mg82,00€5mg192,00€10mg304,00€25mg522,00€50mg713,00€100mg1.018,00€1mL*10mM (DMSO)212,00€Amantadine hydrochloride
CAS:Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.Formula:C10H18ClNPurezza:99.98%Colore e forma:Solid CrystallinePeso molecolare:187.71Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Formula:C24H25N7OPurezza:99.95% - 99.96%Colore e forma:SolidPeso molecolare:427.5BRD6989
CAS:BRD6989, a cortistatin A analog, inhibits CDK8/19, enhances IL-10, and binds CDK8 with a 200 nM IC50.Formula:C16H16N4Purezza:99.43%Colore e forma:SolidPeso molecolare:264.33Ref: TM-T14778
1mg34,00€5mg66,00€10mg92,00€25mg177,00€50mg268,00€100mg398,00€200mg575,00€1mL*10mM (DMSO)73,00€Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Formula:C26H36Cl2N8OPurezza:97.4%Colore e forma:SolidPeso molecolare:547.52Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Formula:C24H32Cl2N8OPurezza:99.69% - 99.89%Colore e forma:SolidPeso molecolare:519.47
