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CDK

CDK

Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.

Trovati 522 prodotti di "CDK"

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  • CDK4/6-IN-9
    Targetmol
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    CDK4/6-IN-9

    CAS:
    CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.
    Formula:C22H23FN8
    Colore e forma:Solid
    Peso molecolare:418.47

    Ref: TM-T62192

  • CDK1-IN-1
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    CDK1-IN-1

    CAS:
    CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.
    Formula:C27H23N5O3
    Colore e forma:Solid
    Peso molecolare:465.5

    Ref: TM-T62970

  • Indirubin-5-sulfonate
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    Indirubin-5-sulfonate

    CAS:
    Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.
    Formula:C16H10N2O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:342.33

    Ref: TM-T11653

  • SMAPP1
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    SMAPP1

    CAS:
    SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.
    Formula:C27H25N5O5S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:563.65

    Ref: TM-T28818

  • CDK7-IN-8
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    CDK7-IN-8

    CAS:
    CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.
    Formula:C25H38N8O3
    Colore e forma:Solid
    Peso molecolare:498.62

    Ref: TM-T63381

  • Cdc7-IN-5
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    Cdc7-IN-5

    CAS:
    <p>Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.</p>
    Formula:C25H23N3O5
    Purezza:97.15%
    Colore e forma:Solid
    Peso molecolare:445.47

    Ref: TM-T10727

  • CDK9/10/GSK3β-IN-1
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    CDK9/10/GSK3β-IN-1

    CAS:
    CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50
    Formula:C29H24ClN3O4S
    Colore e forma:Solid
    Peso molecolare:546.04

    Ref: TM-T63851

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
    Formula:C24H16FN5O
    Colore e forma:Solid
    Peso molecolare:409.42

    Ref: TM-T10836

  • AS2863619 free base
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    AS2863619 free base

    CAS:
    AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.
    Formula:C16H12N8O
    Colore e forma:Solid
    Peso molecolare:332.32

    Ref: TM-T10382

  • Aloisine A
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    Aloisine A

    CAS:
    Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.
    Formula:C16H17N3O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:267.33

    Ref: TM-T21377

  • CDK-IN-10
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    CDK-IN-10

    CAS:
    CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.
    Formula:C18H18N4O2
    Purezza:97.07%
    Colore e forma:Solid
    Peso molecolare:322.36

    Ref: TM-T60869

  • K 00546
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    K 00546

    CAS:
    K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).
    Formula:C15H13F2N7O2S2
    Purezza:99.12%
    Colore e forma:Solid
    Peso molecolare:425.44

    Ref: TM-T21950

  • CDK4/6-IN-8
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    CDK4/6-IN-8

    CAS:
    CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).
    Formula:C18H18N6O5
    Colore e forma:Solid
    Peso molecolare:398.37

    Ref: TM-T61892

  • FLT3/CDK4-IN-1
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    FLT3/CDK4-IN-1

    CAS:
    FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) & CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.
    Formula:C25H28F2N8
    Colore e forma:Solid
    Peso molecolare:478.54

    Ref: TM-T63135

  • CDK12-IN-E9
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    CDK12-IN-E9

    CAS:
    CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.
    Formula:C24H30N6O2
    Colore e forma:Solid
    Peso molecolare:434.53

    Ref: TM-T14915

  • Alsterpaullone, 2-Cyanoethyl
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    Alsterpaullone, 2-Cyanoethyl

    CAS:
    Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.
    Formula:C19H14N4O3
    Colore e forma:Solid
    Peso molecolare:346.34

    Ref: TM-T68555

  • CDK7-IN-20
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    CDK7-IN-20

    CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.
    Formula:C30H26N6O3
    Colore e forma:Solid
    Peso molecolare:518.57

    Ref: TM-T73163

  • CDK7-IN-13
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    CDK7-IN-13

    CAS:
    CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.
    Formula:C20H23F3N6OS
    Purezza:99.22%
    Colore e forma:Solid
    Peso molecolare:452.5

    Ref: TM-T62759

  • Indirubin-3'-monoxime-5-sulphonic acid
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    Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.
    Formula:C16H11N3O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:357.34

    Ref: TM-T11652

  • BSJ-01-175
    Targetmol
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    BSJ-01-175

    CAS:
    BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.
    Formula:C30H33ClN6O2
    Colore e forma:Solid
    Peso molecolare:545.08

    Ref: TM-T63841