Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 283 prodotti di "Microtubulo associato"
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TCS 2210
CAS:TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.Formula:C18H17N3O3Purezza:98.62%Colore e forma:SolidPeso molecolare:323.35Ref: TM-T23446
1mg90,00€2mg123,00€5mg182,00€10mg274,00€25mg469,00€50mg643,00€100mg914,00€500mg1.833,00€1mL*10mM (DMSO)187,00€DM1-SMe
CAS:<p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>Formula:C36H50ClN3O10S2Purezza:99.61%Colore e forma:SolidPeso molecolare:784.38JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Formula:C28H27N5O2Purezza:99.58%Colore e forma:SolidPeso molecolare:465.55Ref: TM-T15612
1mg116,00€5mg240,00€10mg358,00€25mg558,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)246,00€JG-23
CAS:JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) ofFormula:C19H16ClN3OS2Colore e forma:SolidPeso molecolare:401.93Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Formula:C24H25N5O4Colore e forma:SolidPeso molecolare:447.49N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Formula:C20H23NO5Colore e forma:SolidPeso molecolare:357.4Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFormula:C38H65N11O9Colore e forma:SolidPeso molecolare:819.99Anticancer agent 40
CAS:Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).Formula:C25H29NO6Colore e forma:SolidPeso molecolare:439.5THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Formula:C20H21FN2O2Colore e forma:SolidPeso molecolare:340.39Tubulin polymerization-IN-52
CAS:Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].Formula:C21H18F3N5O3Colore e forma:SolidPeso molecolare:445.39Valecobulin hydrochloride
CAS:Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Formula:C26H29ClN6O5SPurezza:99.52%Colore e forma:SolidPeso molecolare:573.06Ref: TM-T13278
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)207,00€ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Formula:C17H21N5O3SColore e forma:SolidPeso molecolare:375.45MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Formula:C16H11FN4Purezza:98%Colore e forma:SolidPeso molecolare:278.28Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Formula:C45H47NO13Colore e forma:SolidPeso molecolare:809.85CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Formula:C25H21N3O2Colore e forma:SolidPeso molecolare:395.453,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Formula:C16H16O4Colore e forma:SolidPeso molecolare:272.3Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Formula:C43H70N6O7SColore e forma:SolidPeso molecolare:815.12PBB3
CAS:PBB3 is a tau-specific PET tracer.Formula:C17H15N3OSColore e forma:SolidPeso molecolare:309.39Tubulin inhibitor 25
CAS:Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.Formula:C26H22O8Colore e forma:SolidPeso molecolare:462.45Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purezza:98%Colore e forma:SolidPeso molecolare:643.30
