Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 284 prodotti di "Microtubulo associato"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ST-401
CAS:ST-401, a microtubule-targeting agent (MTA), functions as a brain-penetrant microtubule (MT) assembly inhibitor. It disrupts microtubule (MT) function by gently and reversibly reducing MT assembly, which leads to mitotic delay and interphase cell death. ST-401 demonstrates potent antitumor activity.Formula:C24H20N2OColore e forma:SolidPeso molecolare:352.434-Desacetylvinblastine hydrazide
CAS:Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.Formula:C43H56N6O7Colore e forma:SolidPeso molecolare:768.94Semorinemab
CAS:Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease.Purezza:95% - 96.7% (SDS-PAGE); 97.2% (SEC-HPLC)Colore e forma:LiquidGosuranemab
CAS:<p>Gosuranemab (BMS-986168), a humanized IgG4 mAb, targets tau residues 15-22, and may aid in Alzheimer’s research.</p>Purezza:95% - 95%Colore e forma:LiquidPosdinemab
CAS:<p>Posdinemab, a humanized IgG1κ antibody, targets the microtubule-associated protein tau (MAPT) [1].</p>Colore e forma:LiquidTubulin polymerization-IN-2
CAS:Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.Formula:C17H12F2N2O2Colore e forma:SolidPeso molecolare:314.29Auristatin F
CAS:Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.Formula:C40H67N5O8Purezza:98.41% - 99.25%Colore e forma:SolidPeso molecolare:745.99Tubulin polymerization-IN-37
CAS:Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.Formula:C19H20N2O4Colore e forma:SolidPeso molecolare:340.37Microtubule inhibitor 5
CAS:Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.Formula:C22H15FN2O4Colore e forma:SolidPeso molecolare:390.36Tubulin polymerization-IN-27
CAS:Compound 5j inhibits tubulin polymerization, arrests cell cycle at G2/M phase, and induces apoptosis.Formula:C22H20N2O2Colore e forma:SolidPeso molecolare:344.41Tubulin inhibitor 26
CAS:Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.Formula:C17H19N3O3Colore e forma:SolidPeso molecolare:313.35Tubulin inhibitor 20
CAS:Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].Formula:C19H18O4Colore e forma:SolidPeso molecolare:310.34Amphethinile
CAS:Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.Formula:C15H11N3SPurezza:98%Colore e forma:SolidPeso molecolare:265.33OSIP-486823
CAS:OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.Formula:C29H28FNO4Purezza:98.59%Colore e forma:SolidPeso molecolare:473.54AMXI-5001
CAS:AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.Formula:C25H20FN5O3Colore e forma:SolidPeso molecolare:457.46SB26019
CAS:SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.Formula:C24H20O4Colore e forma:SolidPeso molecolare:372.41Anticancer agent 60
CAS:Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.Formula:C27H33N5O4SColore e forma:SolidPeso molecolare:523.65DJ101
CAS:DJ101: A stable tubulin inhibitor that bypasses multidrug resistance efflux pumps.Formula:C23H20N4O3Purezza:98%Colore e forma:SolidPeso molecolare:400.43Tubulin polymerization-IN-19
CAS:Tubulin aggregation-IN-19 (compound 4) is a potent tubulin aggregation inhibitor that has shown potential in breast cancer and drug-resistant colon cancer.Formula:C25H25NO5Colore e forma:SolidPeso molecolare:419.47Antitumor agent-68
CAS:Potent Antitumor-68 inhibits tubulin, IC50: 3.6μM HeLa, 3.8μM MCF-7; also scavenges ROS/DPPH dose-dependently.Formula:C17H11NO2Colore e forma:SolidPeso molecolare:261.27
