c-Myc
Gli inibitori di c-Myc prendono di mira la proteina c-Myc, un fattore di trascrizione che svolge un ruolo cruciale nella crescita cellulare, proliferazione e apoptosi. c-Myc regola l'espressione di numerosi geni coinvolti nel ciclo cellulare ed è spesso sovraespresso in vari tipi di cancro, portando a una proliferazione cellulare incontrollata e alla crescita tumorale. L'inibizione di c-Myc può interrompere questi processi, inducendo l'arresto del ciclo cellulare e l'apoptosi nelle cellule tumorali. Gli inibitori di c-Myc sono strumenti importanti nella ricerca sul cancro e nello sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori di c-Myc di alta qualità per supportare la tua ricerca in oncologia, regolazione del ciclo cellulare e controllo trascrizionale.
Trovati 69 prodotti di "c-Myc"
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MYCi361
CAS:<p>MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).</p>Formula:C26H16ClF9N2O2Purezza:99.52%Colore e forma:SolidPeso molecolare:594.86MYCi975
CAS:<p>MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.</p>Formula:C25H16Cl2F6N2O2Purezza:99.3% - 99.82%Colore e forma:SolidPeso molecolare:561.3Eragidomide
CAS:<p>Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.</p>Formula:C22H18ClF2N3O4Purezza:97.51% - 99.63%Colore e forma:SolidPeso molecolare:461.85Ceramides Mixture
CAS:<p>Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.</p>Formula:C36H71NO4Purezza:98%Colore e forma:SolidPeso molecolare:581.967APTO-253
CAS:<p>APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.</p>Formula:C22H14FN5Purezza:98.73%Colore e forma:SolidPeso molecolare:367.38MYCMI-6
CAS:<p>MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.</p>Formula:C20H19N7OPurezza:99.23%Colore e forma:SolidPeso molecolare:373.41KJ Pyr 9
CAS:<p>KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).</p>Formula:C22H15N3O4Purezza:99.56% - ≥98%Colore e forma:SolidPeso molecolare:385.37FIDAS-3
CAS:<p>FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities</p>Formula:C16H15F2NPurezza:97.75%Colore e forma:SolidPeso molecolare:259.29FIDAS-5
CAS:<p>FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.</p>Formula:C15H13ClFNPurezza:97.66% - 98.3%Colore e forma:SolidPeso molecolare:261.72Saxagliptin hydrate
CAS:<p>Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).</p>Formula:C18H25N3O2·H2OPurezza:99.52%Colore e forma:SolidPeso molecolare:333.43MYC-IN-2
CAS:<p>MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.</p>Formula:C25H17N3O2SColore e forma:SolidPeso molecolare:423.49RA-V
<p>RA-V is a natural product that can be used as a reference standard.</p>Formula:C160H202N24O41Colore e forma:SolidPeso molecolare:3117.5c-Myc inhibitor 5
<p>DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.</p>Formula:C30H46N12Colore e forma:SolidPeso molecolare:574.77c-Myc inhibitor 10
CAS:<p>c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.</p>Formula:C28H38N6O3Colore e forma:SolidPeso molecolare:506.64c-Myc inhibitor 12
<p>Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].</p>Formula:C22H24N6OPurezza:98%Colore e forma:SolidPeso molecolare:388.47MDEG-541
<p>MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].</p>Formula:C35H38N4O7SPurezza:98%Colore e forma:SolidPeso molecolare:658.76Anti-c-myc Antibody (9E10)
<p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>Colore e forma:Odour LiquidPROTAC MTP3 degrade-1
<p>PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.</p>Formula:C44H38N6O8Colore e forma:SolidPeso molecolare:778.27511Methylcarbamyl PAF C-8
<p>Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.</p>Colore e forma:Odour Solidc-Myc inhibitor 11
<p>c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in rat</p>Formula:C20H22N6OPurezza:98%Colore e forma:SolidPeso molecolare:362.43CSI86
<p>CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).</p>Formula:C48H50F9N7O7SColore e forma:SolidPeso molecolare:1040WBC100
CAS:<p>WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway</p>Formula:C25H33NO7Purezza:98%Colore e forma:SolidPeso molecolare:459.53Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.308c-Myc inhibitor 7
CAS:<p>c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.</p>Formula:C35H30N6O5Colore e forma:SoildPeso molecolare:614.65Anticancer agent 84
CAS:<p>Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.</p>Formula:C57H67N7O9Colore e forma:SolidPeso molecolare:994.18VGN50
<p>VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.</p>Formula:C121H218N46O32Peso molecolare:2827.68453c-Myc inhibitor 13
<p>c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.</p>Formula:C30H39N9OPeso molecolare:541.32776Cotylenin A
CAS:<p>Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.</p>Formula:C33H50O11Colore e forma:SolidPeso molecolare:622.744H122
<p>H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formula:C45H45ClFN5O8Colore e forma:SolidPeso molecolare:838.319PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Formula:C51H64F2N10O5SColore e forma:SolidPeso molecolare:967.18KL4-219A
<p>KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .</p>Formula:C20H24N2O2SPurezza:99.68%Colore e forma:SolidPeso molecolare:356.48VPC-70063
CAS:<p>VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.</p>Formula:C16H12F6N2SPurezza:99.98%Colore e forma:SolidPeso molecolare:378.34sAJM589
CAS:<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>Formula:C16H10N2OPurezza:98%Colore e forma:SolidPeso molecolare:246.26IRES-C11
CAS:<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>Formula:C13H11Cl2NO4Purezza:99.89%Colore e forma:SolidPeso molecolare:316.14Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Formula:C24H17ClF2N6O4Purezza:99.51% - 99.61%Colore e forma:SolidPeso molecolare:526.88Saxagliptin
CAS:<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formula:C18H25N3O2Purezza:99.17% - 99.95%Colore e forma:SolidPeso molecolare:315.41(S)-10-Hydroxycamptothecin
CAS:<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Formula:C20H16N2O5Purezza:99.09% - 99.81%Colore e forma:SolidPeso molecolare:364.35Mollugin
CAS:<p>Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.</p>Formula:C17H16O4Purezza:99.87% - ≥95%Colore e forma:SolidPeso molecolare:284.31ML327
CAS:<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Formula:C19H18N4O4Purezza:98.47%Colore e forma:SolidPeso molecolare:366.3710074-G5
CAS:<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Formula:C18H12N4O3Purezza:99.51% - 99.67%Colore e forma:SolidPeso molecolare:332.31NNK
CAS:<p>NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.Cost-effective and quality-assured.</p>Formula:C10H13N3O2Purezza:99.63% - 99.92%Colore e forma:SolidPeso molecolare:207.23Lusianthridin
CAS:<p>Lusianthridin is a natural product from Dendrobium venustum.</p>Formula:C15H14O3Purezza:98.49%Colore e forma:SolidPeso molecolare:242.27Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formula:C37H46O12Purezza:99.06% - ≥95%Colore e forma:SolidPeso molecolare:682.7510058-F4
CAS:<p>10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.</p>Formula:C12H11NOS2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:249.35APTO-253 HCl
CAS:<p>APTO-253 (LOR-253/LT-253) is a small-molecule MTF-1 inhibitor with antitumor properties, reducing cyclin D1, hypoxia, and angiogenesis gene expression.</p>Formula:C22H15ClFN5Colore e forma:SolidPeso molecolare:403.8410074-A4
CAS:<p>10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from</p>Formula:C18H14Cl2N2O3SPurezza:99.06%Colore e forma:SolidPeso molecolare:409.29Artemisitene
CAS:<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formula:C15H20O5Purezza:99.58%Colore e forma:SolidPeso molecolare:280.32NY2267
CAS:<p>NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl</p>Formula:C38H43N3O6Purezza:99.16% - 99.27%Colore e forma:SolidPeso molecolare:637.76Idarubicin hydrochloride
CAS:<p>Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).</p>Formula:C26H27NO9·HClPurezza:98.91% - 99.96%Colore e forma:SolidPeso molecolare:533.95BTYNB
CAS:<p>BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.</p>Formula:C12H9BrN2OSPurezza:≥95%Colore e forma:SolidPeso molecolare:309.18EN4
CAS:<p>EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.</p>Formula:C25H24N2O4Purezza:98.51%Colore e forma:SolidPeso molecolare:416.47PARL Protein, Human, Recombinant (Myc)
<p>Required for the control of apoptosis during postnatal growth.</p>Colore e forma:Lyophilized PowderPeso molecolare:37.8 kDa (predicted)ACOX1 Protein, Mouse, Recombinant (Myc)
<p>Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.</p>Colore e forma:Lyophilized PowderPeso molecolare:76.2 kDa (predicted)2-5A-dependent Rnase Protein, Human, Recombinant (Myc)
<p>2-5A-dependent Rnase Protein, Human, Recombinant (Myc) is expressed in E.</p>Purezza:85% - 85%Colore e forma:Lyophilized PowderPeso molecolare:85.1 kDa (predicted)c-Myc inhibitor 9
CAS:<p>c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.</p>Formula:C27H31N5OSColore e forma:SolidPeso molecolare:473.63RK-9123016
CAS:<p>RK-9123016 is a SIRT2 inhibitor.</p>Formula:C16H18N6O3SPurezza:99.65%Colore e forma:SolidPeso molecolare:374.42FUBP1-IN-2
CAS:<p>FUBP1-IN-2 hinders FUBP1, affects c-Myc and p21 expression, and depletes polyamines.</p>Formula:C26H26ClN3O4Colore e forma:SolidPeso molecolare:479.96KSI-3716
CAS:<p>KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.</p>Formula:C17H11BrCl2N2O2Purezza:98.94%Colore e forma:SolidPeso molecolare:426.09BI8622
CAS:<p>BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.</p>Formula:C25H26N6OPurezza:98.28%Colore e forma:SolidPeso molecolare:426.51VPC-70619
CAS:<p>VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.</p>Formula:C16H8ClF3N4OColore e forma:SolidPeso molecolare:364.71c-Myc inhibitor 8
CAS:<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Formula:C19H12BrClF3NO3S2Colore e forma:SolidPeso molecolare:538.79m-Se3
CAS:<p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>Formula:C29H23IN2SePurezza:98%Colore e forma:SolidPeso molecolare:605.37SYHA1815
CAS:<p>SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.</p>Formula:C27H26ClF4N5OColore e forma:SolidPeso molecolare:547.98KI-CDK9d-32
CAS:<p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>Formula:C39H45N9O4Colore e forma:SolidPeso molecolare:703.83c-Myc inhibitor 4
<p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>Formula:C26H33FN6O3Colore e forma:SolidPeso molecolare:496.58BRD4 Inhibitor-40
CAS:<p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>Formula:C27H32N8OColore e forma:SolidPeso molecolare:484.596MY05
CAS:<p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>Formula:C19H11ClN4OColore e forma:SolidPeso molecolare:346.77JY-3-094
CAS:<p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>Formula:C13H8N4O5Purezza:98.72%Colore e forma:SolidPeso molecolare:300.23β-catenin-IN-8
CAS:<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Formula:C15H12ClN3O2SColore e forma:SolidPeso molecolare:333.79
